The Mechanistic Classification of Addictive Drugs
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Chronic administration of psychostimulants produces robust structural and functional changes in mesolimbic circuitry.
“For example, the chronic administration of psychostimulants produces robust structural and functional changes in mesolimbic circuitry, changes that are thought to underlie the addictive properties of these compounds (Lüscher and Ungless, 2006;Kalivas and O'Brien, 2008).”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Lüscher and Ungless, 2006
The ‘Some of the Key Papers on the Cellular Effects of Addictive Drugs’ subsection (page not provided) reports long-term synaptic plasticity in the VTA after exposure to addictive drugs, supporting functional changes in relevant circuitry. It does not establish that chronic psychostimulant administration produces robust structural changes; a cited study in the References instead concerns a single cocaine exposure. (LLM, conf=0.85)
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Cites
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Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
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“All addictive drugs increase dopamine levels in the mesolimbic dopamine syste”
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Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82 · see citing works
“For example, the chronic administration of psychostimulants produces robust structural and functional changes in mesolimbic circuitry, changes that are thought to underlie the addictive properties of these compounds (Lüscher and Ungless, 2006; Kalivas and O ’ Brien, 2008).”
Dougalis, A. G., Matthews, G. A. C., Bishop, M. W., Brischoux, F., Kobayashi, K., & Ungless, M. A. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08255.x · Cited by 81 · see citing works
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- Authors
- Lüscher, C., & Ungless, M. A.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Lüscher, Christian
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-11-14
- Volume
- 3
- Issue
- 11
- Pages
- e437
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- PMC
- PMC1635740
- OpenAlex
- W2003661073
- Cited by
- 255
- References
- 8
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 14 · 2023: 22 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 12 · 2018: 16 · 2017: 12 · 2016: 12 · 2015: 13 · 2014: 15 · 2013: 10 · 2012: 15
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Royal Society
- Gatsby Charitable Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fondation Leenaards
- Université de Genève
- Medical Research Council
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- drugs of abuse, drug classification, substance use disorders
- MeSH terms
- Animals, Carrier Proteins, Pharmaceutical Preparations, Humans, Ion Channels, Biogenic Monoamines, Substance-Related Disorders, Receptors, G-Protein-Coupled
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