The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effects of Serine/Threonine Protein Phosphatases on Ion Channels in Excitable Membranes
Abstract
This review deals with the influence of serine/threonine-specific protein phosphatases on the function of ion channels in the plasma membrane of excitable tissues. Particular focus is given to developments of the past decade. Most of the electrophysiological experiments have been performed with protein phosphatase inhibitors. Therefore, a synopsis is required incorporating issues from biochemistry, pharmacology, and electrophysiology. First, we summarize the structural and biochemical properties of protein phosphatase (types 1, 2A, 2B, 2C, and 3–7) catalytic subunits and their regulatory subunits. Then the available pharmacological tools (protein inhibitors, nonprotein inhibitors, and activators) are introduced. The use of these inhibitors is discussed based on their biochemical selectivity and a number of methodological caveats. The next section reviews the effects of these tools on various classes of ion channels (i.e., voltage-gated Ca 2+and Na+channels, various K+channels, ligand-gated channels, and anion channels). We delineate in which cases a direct interaction between a protein phosphatase and a given channel has been proven and where a more complex regulation is likely involved. Finally, we present ideas for future research and possible pathophysiological implications.
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Cites
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Cyanobacteria secondary metabolites—the cyanotoxins
Carmichael, W. W. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb01858.x · Cited by 1,457
Sutherland, C., Leighton, I. A., & Cohen, P. (1993) · Biochemical Journal · doi:10.1042/bj2960015 · Cited by 903
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science · doi:10.1126/science.1325671 · Cited by 601
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F. B., Watt, P., & Cohen, P. (1990) · Nature · doi:10.1038/348302a0 · Cited by 519
Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase
Lieberman, D. N., & Mody, I. (1994) · Nature · doi:10.1038/369235a0 · Cited by 480
Hemmings, B. A., Adams-Pearson, C., Maurer, F., Mueller, P., Goris, J., Merlevede, W., Hofsteenge, J., & Stone, S. R. (1990) · Biochemistry · doi:10.1021/bi00465a002 · Cited by 243
The absence of a major Ca 2+ signaling pathway in GABAergic neurons of the hippocampus
Sík, A., Hájos, N., Gulácsi, A., Mody, I., & Freund, T. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3245 · Cited by 186
Rosenmund, C., & Westbrook, G. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019884 · Cited by 133
Medina, I., Filippova, N., Bakhramov, A., & Bregestovski, P. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021603 · Cited by 50
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Cheng, C. Y., & Mruk, D. D. (2002) · Physiological Reviews · doi:10.1152/physrev.00009.2002 · Cited by 567
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms
Daoudal, G., & Debanne, D. (2003) · Learning & Memory · doi:10.1101/lm.64103 · Cited by 543
Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function
Gergs, U., Boknik, P., Buchwalow, I., Fabritz, L., Matus, M., Justus, I., Hanske, G., Schmitz, W., & Neumann, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405770200 · Cited by 125
Self-citationHo, D., Yan, L., Iwatsubo, K., Vatner, D. E., & Vatner, S. F. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9183-5 · Cited by 68
Raveendran, R., Devi Suma Priya, S., Mayadevi, M., Steephan, M., Santhoshkumar, T. R., Cheriyan, J., Sanalkumar, R., Pradeep, K. K., James, J., & Omkumar, R. V. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06108.x · Cited by 63
Metadata
- Authors
- Herzig, S., & Neumann, J.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2000-01-01
- Volume
- 80
- Issue
- 1
- Pages
- 173-210
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2117767094
- Cited by
- 272
- References
- 10
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
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