The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Retinoids in Embryonal Development
Abstract
The key role of vitamin A in embryonal development is reviewed. Special emphasis is given to the physiological action of retinoids, as evident from the retinoid ligand knockout models. Retinoid metabolism in embryonic tissues and teratogenic consequences of retinoid administration at high doses are presented. Physiological and pharmacological actions of retinoids are outlined and explained on the basis of their interactions as ligands of the nuclear retinoid receptors. Immediate target genes and the retinoid response elements of their promoters are summarized. The fundamental role of homeobox genes in embryonal development and the actions of retinoids on their expression are discussed. The similarity of the effects of retinoid ligand knockouts to effects of compound retinoid receptor knockouts on embryogenesis is presented. Although much remains to be clarified, the emerging landscape offers exciting views for future research.
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
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“All-trans RA is the natural ligand for the retinoic acid receptors (RAR) (71, 221), and 9-cis-RA for the RXR (137), although the latter compound binds to both receptor families.”
BackgroundLammer, E. J., Chen, D. T., Hoar, R. M., Agnish, N. D., Benke, P. J., Braun, J. T., Curry, C. J., Fernhoff, P. M., Grix, A. W., Lott, I. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198510033131401 · Cited by 1,942
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Multiplicity generates diversity in the retinoic acid signalling pathways
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Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase
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Embryonic development and pattern formation
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Cited by
Gene expression regulation by retinoic acid
Balmer, J. E., & Blomhoff, R. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r100015-jlr200 · Cited by 1,039
Retinoic acid regulates sex-specific timing of meiotic initiation in mice
Koubova, J., Menke, D. B., Zhou, Q., Capel, B., Griswold, M. D., & Page, D. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510813103 · Cited by 941
Nuclear retinoid receptors and the transcription of retinoid-target genes
Bastien, J., & Rochette-Egly, C. (2004) · Gene · doi:10.1016/j.gene.2003.12.005 · Cited by 773
Role of Vitamin A in the Immune System
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090258 · Cited by 597
T HE R OLE OF V ITAMIN A IN M AMMALIAN R EPRODUCTION AND E MBRYONIC D EVELOPMENT
Clagett-Dame, M., & DeLuca, H. F. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102745e · Cited by 461
Metadata
- Authors
- Ross, S. A., McCaffery, P. J., Drager, U. C., & De Luca, L. M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2000-07-01
- Volume
- 80
- Issue
- 3
- Pages
- 1021-1054
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W1841957993
- Cited by
- 866
- References
- 8
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
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