The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Photodynamic Therapy and the Development of Metal-Based Photosensitisers
Open accessAbstract
Photodynamic therapy (PDT) is a treatment modality that has been used in the successful treatment of a number of diseases and disorders, including age-related macular degeneration (AMD), psoriasis, and certain cancers. PDT uses a combination of a selectively localised light-sensitive drug (known as a photosensitiser) and light of an appropriate wavelength. The light-activated form of the drug reacts with molecular oxygen to produce reactive oxygen species (ROS) and radicals; in a biological environment these toxic species can interact with cellular constituents causing biochemical disruption to the cell. If the homeostasis of the cell is altered significantly then the cell enters the process of cell death. The first photosensitiser to gain regulatory approval for clinical PDT was Photofrin. Unfortunately, Photofrin has a number of associated disadvantages, particularly pro-longed patient photosensitivity. To try and overcome these disadvantages second and third generation photosensitisers have been developed and investigated. This Review highlights the key photosensitisers investigated, with particular attention paid to the metallated and non-metallated cyclic tetrapyrrolic derivatives that have been studied in vitro and in vivo; those which have entered clinical trials; and those that are currently in use in the clinic for PDT.
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O’Connor, A. E., Gallagher, W. M., & Byrne, A. T. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00585.x · Cited by 1,191
Dye Sensitizers for Photodynamic Therapy
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Oncologic photodynamic therapy photosensitizers: A clinical review
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Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds
Ramesh, R., & Reddy, D. S. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00718 · Cited by 624
Phthalocyanines as medicinal photosensitizers: Developments in the last five years
Li, X., Zheng, B.-D., Peng, X.-H., Li, S.-Z., Ying, J.-W., Zhao, Y., Huang, J.-D., & Yoon, J. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.08.003 · Cited by 523
Metadata
- Authors
- Josefsen, L. B., & Boyle, R. W.
- Venue
- Metal-Based Drugs
- Publisher
- Wiley
- Published
- 2008-09-07
- Volume
- 2008
- Pages
- 1-23
- ISSN
- 0793-0291 (ISSN-L)
- 1687-5486
- OpenAlex
- W1975823196
- Cited by
- 536
- References
- 65
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
