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Cited by 69Peroxisome Proliferator-Activated ReceptorsNuclear Receptors and SignalingAdipose Tissue and Metabolism

Molecular mechanisms and genome-wide aspects of PPAR subtype specific transactivation

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Bugge, Anne, Mandrup, Susanne·2010·PPAR Research
DOI 10.1155/2010/169506PMC PMC2938449
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Abstract

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR, /, and activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.

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Cited by

Sorted by citations

Authors
Bugge, A., & Mandrup, S.
Affiliations
University of Southern Denmark (DK)
Corresponding author
Mandrup, Susanne
ORCID
Venue
PPAR Research
Publisher
Wiley
Published
2010
Volume
2010
Pages
1-12
ISSN
  • 1687-4757 (ISSN-L)
  • 1687-4765
DOI
10.1155/2010/169506
PMC
PMC2938449
OpenAlex
W2076604793
Cited by
69
References
6
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 10
FWCI
3.13
Type
journal article
Language
en
Open access
Licence
Locations
  • PPAR Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
peroxisome proliferator-activated receptors, PPARα, PPARδ, PPARγ, nuclear receptor transcriptional regulation, fat metabolism, energy homeostasis, inflammation

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