The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC
Open accessAbstract
Adult bone marrow multipotential stromal cells (MSCs) hold great promise in regenerative medicine and tissue engineering. However, due to their low numbers upon harvesting, MSCs need to be expanded in vitro without biasing future differentiation for optimal utility. In this concept paper, we focus on the potential use of epidermal growth factor (EGF), prototypal growth factor for enhancing the harvesting and/or differentiation of MSCs. Soluble EGF was shown to augment MSC proliferation while preserving early progenitors within MSC population, and thus did not induce differentiation. However, tethered form of EGF was shown to promote osteogenic differentiation. Soluble EGF was also shown to increase paracrine secretions including VEGF and HGF from MSC. Thus, soluble EGF can be used not only to expand MSC in vitro, but also to enhance paracrine secretion through drug-releasing MSC-encapsulated scaffolds in vivo. Tethered EGF can also be utilized to direct MSC towards osteogenic lineage both in vitro and in vivo.
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Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610
Induction of tenascin in healing wounds
Mackie, E. J., Halfter, W., & Liverani, D. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.6.2757 · Cited by 555 · cited 1×
“Tenacin C is produced by keratinocytes and fibroblasts during wound healing process, and thus it might serve as endogenous tethered EGF-like ligands and produce promigratory tracks for fibroblasts or implanted MSCs within the wound healing edges [57, 60].”
Background
Cited by
Spheroid Culture of Mesenchymal Stem Cells
Cesarz, Z., & Tamama, K. (2016) · Stem Cells International · doi:10.1155/2016/9176357 · Cited by 475
Self-citationProtein post-translational modifications and regulation of pluripotency in human stem cells
Wang, Y.-C., Peterson, S. E., & Loring, J. F. (2014) · Cell Research · doi:10.1038/cr.2013.151 · Cited by 395
Therapeutic Applications of Mesenchymal Stromal Cells: Paracrine Effects and Potential Improvements
Doorn, J., Moll, G., Le Blanc, K., van Blitterswijk, C., & de Boer, J. (2012) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2011.0488 · Cited by 307
Growth factor regulation of proliferation and survival of multipotential stromal cells
Rodrigues, M., Griffith, L. G., & Wells, A. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt32 · Cited by 301
Self-citationKerpedjieva, S. S., Kim, D. S., Barbeau, D. J., & Tamama, K. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0711 · Cited by 53
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Metadata
- Authors
- Tamama, K., Kawasaki, H., & Wells, A.
- Venue
- Journal of Biomedicine and Biotechnology
- Publisher
- Wiley
- Published
- 2010
- Volume
- 2010
- Pages
- 1-10
- ISSN
- 1110-7243 (ISSN-L)
- 1110-7251
- OpenAlex
- W2088773865
- Cited by
- 161
- References
- 3
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tamama, K., Kawasaki, H., & Wells, A. (2010). Epidermal Growth Factor (EGF) Treatment on Multipotential Stromal Cells (MSCs). Possible Enhancement of Therapeutic Potential of MSC. Journal of Biomedicine and Biotechnology. https://doi.org/10.1155/2010/795385
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