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Cited by 109Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsRegulation of Appetite and Obesity

Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy

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Hamilton, JillK, Conwell, LouiseS, Syme, Catriona, Ahmet, Alexandra, Jeffery, Allison, Daneman, Denis·2011·International Journal of Pediatric Endocrinology
DOI 10.1155/2011/417949PMC PMC3198743
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Abstract

Objective. To assess the effect of combined diazoxide-metformin therapy in obese adolescents treated for craniopharyngioma. Design. A prospective open-label 6-month pilot treatment trial in 9 obese subjects with craniopharyngioma. Diazoxide (2 mg/kg divided b.i.d., maximum 200 mg/day) and metformin (1000 mg b.i.d.). Whole body insulin sensitivity index (WBISI) and area-under-the-curve insulin (AUC(ins)) were calculated. Results. Seven subjects completed: 4M/3F, mean ± SD age 15.4 ± 2.9 years, weight 99.7 ± 26.3 kg, BMI 35.5 ± 5.6 kg/m(2), and BMI SDS 2.3 ± 0.3. Two were withdrawn due to vomiting and peripheral edema. Of participants completing the study, the mean ± SD weight gain, BMI, and BMI SDS during the 6 months were reduced compared to the 6 months prestudy (+1.2 ± 5.9 versus +9.5 ± 2.7 kg, P = .004; -0.3 ± 2.3 versus +2.2 ± 1.5 kg/m(2), P = .04; -0.04 ± 0.15 versus +0.11 ± 0.08, P = .021, resp.). AUC(ins) correlated with weight loss (r = 0.82, P = .02) and BMI decrease (r = 0.96, P = .009). Conclusion. Combined diazoxide-metformin therapy was associated with reduced weight gain in patients with hypothalamic obesity. AUC(ins) at study commencement predicted effectiveness of the treatment.

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  • In a 6-month open-label pilot study of 9 individuals with hypothalamic obesity from craniopharyngioma, combining diazoxide with metformin to avoid hyperglycemia led to attenuated weight gain relative to pretreatment.

    “A separate, 6-month, open-label pilot study in individuals with hypothalamic obesity from craniopharyngioma (n = 9) combined diazoxide with metformin to avoid hyperglycemia led to attenuated weight gain relative to pre treatment (39).”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [39]

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Research works printed but not linked: 28

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Cited by

Sorted by citations

Authors
Hamilton, J., Conwell, L., Syme, C., Ahmet, A., Jeffery, A., & Daneman, D.
Affiliations
University of Toronto (CA)
Corresponding author
Hamilton, JillK
ORCID
Venue
International Journal of Pediatric Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2011
Volume
2011
Issue
1
Pages
417949
ISSN
  • 1687-9848 (ISSN-L)
  • 1687-9856
DOI
10.1155/2011/417949
PMC
PMC3198743
OpenAlex
W2067745705
Cited by
109
References
4
Citations by year
2026: 8 · 2025: 5 · 2024: 12 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 10 · 2014: 4 · 2013: 5 · 2012: 7
FWCI
5.25
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • International Journal of Pediatric Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Hospital for Sick Children
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
hypothalamic obesity, craniopharyngioma, diazoxide, metformin, combination therapy, adolescents, weight loss, insulin sensitivity, insulin resistance

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