Multidisciplinary Approach for Hypothalamic Obesity in Children and Adolescents: A Preliminary Study
Open accessAbstract
Hypothalamic obesity (HO) is delineated by an inexorable weight gain in subjects with hypothalamic disorder (congenital or acquired). The aim of the present study was to evaluate the effect of a multidisciplinary approach on weight trend and metabolic outcome in children and adolescents with hypothalamic disease who were overweight or obese. Thirteen patients (aged 8.1–16.1 years) received a personalized diet, accelerometer-based activity monitoring, and psychological assessment. Height, weight, body mass index (BMI), and serum metabolic parameters were assessed at baseline (T0) and after six months (T1). Metformin was introduced at T1 in four subjects who were then re-evaluated after six months (T2). At T1, weight gain was significantly reduced compared with T0 (0.29 ± 0.79 kg/month vs. 0.84 ± 0.55 kg/month, p = 0.03), and weight standard deviation score (SDS) and BMI SDS did not change significantly, as serum metabolic parameters. The four subjects treated with metformin showed a reduction of weight SDS and BMI SDS at T2. In conclusion, patients treated with our multidisciplinary approach showed, after 6 months, favorable results characterized by decreased weight gain and stabilization of weight SDS and BMI SDS in a condition usually characterized by inexorable weight gain. However, further analysis, larger cohorts, and longer follow-up are needed to confirm these preliminary data.
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In one small series, metformin helped stabilize weight in individuals already receiving an intense lifestyle modification intervention.
“in one small series, metformin helped to stabilize weight in individuals already receiving an intense lifestyle modification intervention (49).”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [49]
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- Authors
- Tessaris, D., Matarazzo, P., Tuli, G., Tuscano, A., Rabbone, I., Spinardi, A., Lezo, A., Fenocchio, G., Buganza, R., & de Sanctis, L.
- Affiliations
- Ospedale Regina Margherita (IT)
- University of Turin (IT)
- Pediatric Endocrinology Unit, Regina Margherita Children’s Hospital, University of Turin, 10126 Turin, Italy
- Corresponding author
- Tessaris, Daniele
- Venue
- Children
- Publisher
- MDPI AG
- Published
- 2021-06-22
- Volume
- 8
- Issue
- 7
- Pages
- 531
- ISSN
- 2227-9067 (ISSN-L)
- PMC
- PMC8304472
- OpenAlex
- W3177030786
- Cited by
- 11
- References
- 46
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Children (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università degli Studi di Torino
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hypothalamic obesity, hypothalamic disorders, childhood obesity, adolescents, multidisciplinary care, personalized diet, physical activity monitoring, metformin, weight gain, body mass index, metabolic parameters, psychological assessment
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