Atherosclerosis and thrombosis: insights from large animal models

Vilahur, Gemma; Padro, Teresa; Badimon, Lina

doi:10.1155/2011/907575

Cited by 118Atherosclerosis and Cardiovascular DiseasesBlood Coagulation and Thrombosis MechanismsAortic Thrombus and Embolism

Atherosclerosis and thrombosis: insights from large animal models

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Vilahur, Gemma, Padro, Teresa, Badimon, Lina·2011·BioMed Research International

DOI 10.1155/2011/907575PMC PMC3022266

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Abstract

Atherosclerosis and its thrombotic complications are responsible for remarkably high numbers of deaths. The combination of in vitro, ex vivo, and in vivo experimental approaches has largely contributed to a better understanding of the mechanisms underlying the atherothrombotic process. Indeed, different animal models have been implemented in atherosclerosis and thrombosis research in order to provide new insights into the mechanisms that have already been outlined in isolated cells and protein studies. Yet, although no model completely mimics the human pathology, large animal models have demonstrated better suitability for translation to humans. Indeed, direct translation from mice to humans should be taken with caution because of the well-reported species-related differences. This paper provides an overview of the available atherothrombotic-like animal models, with a particular focus on large animal models of thrombosis and atherosclerosis, and examines their applicability for translational research purposes as well as highlights species-related differences with humans.

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Human and murine lipid processing differ: humans are LDL-based and mice are HDL-based.
“differences in human versus murine lipid processing (i.e. LDL-based versus HDL-based, respectively) [113]”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [113]
A high-fat diet in animals is a well-established way to create atherosclerosis models.
“Although the use of the high-fat diet in animals (e.g. atherosclerosis models) has been a well-established method to generate these models”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [113]
Mice and rats are not all suitable for atherosclerosis research because of intrinsic genetic differences, greater resistance to atherogenesis, and the high-cholesterol diet.
“not all experimental models (i.e. mice and rats) are acceptable for atherosclerosis due to intrinsic genetic differences, their higher resistance to atherogenesis and the high cholesterol diet [112,113]”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [113]

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Thrombosis: Studies under Flow Conditions
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Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model
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Dealing with in-stent restenosis
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New “Ex Vivo” Radioisotopic Method of Quantitation of Platelet Deposition – Studies in Four Animal Species
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Inhibition of thrombosis by a novel platelet selective S-nitrosothiol compound without hemodynamic side effects
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Ovariectomy increases vascular calcification via the OPG/RANKL cytokine signalling pathway
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Effect of iron deficiency onTrichuris suisandAscaris suuminfections in pigs
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Atherosclerosis in a rhesus monkey with genetic hypercholesterolemia and elevated plasma Lp(a)
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A model of femoral artery thrombolysis in dogs
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Prevention of Reocclusion following Tissue-Type Plasminogen Activator-Induced Thrombolysis by the RGD-Containing Peptide, Echistatin, in a Canine Model of Coronary Thrombosis
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Aortic medial necrosis with or without thrombosis in rabbits treated with Russell's viper venom and angiotensin II
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Protein disulphide isomerase-mediated LA419– NO release provides additional antithrombotic effects to the blockade of the ADP receptor
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Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia
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Administration of eptifibatide to acute coronary syndrome patients receiving enoxaparin or unfractionated heparin
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Endothelin Receptor Blockade and In-Stent Restenosis
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Coronary vascular remodeling and coronary resistance during chronic ischemia
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Comparative Study of Antithrombotic Effect of a Low Molecular Weight Heparin and Unfractionated Heparin in an ex Vivo Model of Deep Arterial Injury
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Clopidogrel-induced qualitative changes in thrombus formation correlate with stent patency in injured pig cervical arteries
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Purification of the Porcine Platelet GP IIb-IIIa Complex and the Propolypeptide of von Willebrand Factor
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Plasma and aortic lipids in experimental canine atherosclerosis
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[40]White C Ramee S Banks A Wiktor D Price H Swindle MM The Yucatan miniature swine: an atherogenic model to assess the early potency rates of an endovascular stent Swine as Models in Biomedical Research 1992 Ames, Iowa, USA Iowa State University Press 156 162

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doi:10.1155/2011/907575 Review Article Atherosclerosis and Thrombosis: Insights from Large Animal Models
Vilahur, G., Padró, T., & Badimón, L. (2010)
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Modelos experimentales de aterosclerosis
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Authors: Vilahur, G., Padro, T., & Badimon, L.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Vilahur, Gemma
Venue: BioMed Research International
Publisher: Wiley
Published: 2011-01
Volume: 2011
Issue: 1
Pages: 907575-907575
ISSN: 1110-7243 (ISSN-L)
2314-6133
2314-6141
DOI: 10.1155/2011/907575
PMC: PMC3022266
OpenAlex: W1986797668
Cited by: 118
References: 145
Citations by year: 2025: 3 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 25 · 2012: 15
FWCI: 1.52
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor, 1 d)
Locations: BioMed Research International (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Eli Lilly and Company
Ministerio de Ciencia e Innovación
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Thrombus and Embolism
Keywords: atherosclerosis, thrombosis, atherothrombosis, large animal model, species differences, translational research, mouse-to-human translation, experimental model
MeSH terms: Animals, Disease Models, Animal, Dogs, Humans, Swine, Thrombosis, Biomedical Research, Atherosclerosis

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