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Cited by 27

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin

Chen, Chia-Hao, Uang, Yow-Shieng, Wang, Shang-Ta, Yang, Jyh-Chin, Lin, Chun-Jung·2012·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2012/127043
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Abstract

Red yeast rice (RYR) can reduce cholesterol through its active component, lovastatin. This study was to investigate the pharmacokinetic properties of lovastatin in RYR products and potential RYR-drug interactions. Extracts of three registered RYR products (LipoCol Forte, Cholestin, and Xuezhikang) were more effective than pure lovastatin in inhibiting the activities of cytochrome P450 enzymes and P-glycoprotein. Among CYP450 enzymes, RYR showed the highest inhibition on CYP1A2 and CYP2C19, with comparable inhibitory potencies to the corresponding typical inhibitors. In healthy volunteers taking the RYR product LipoCol Forte, the pharmacokinetic properties of lovastatin and lovastatin acid were linear in the dose range of 1 to 4 capsules taken as a single dose and no significant accumulation was observed after multiple dosing. Concomitant use of one LipoCol Forte capsule with nifedipine did not change the pharmacokinetics of nifedipine. Yet, concomitant use of gemfibrozil with LipoCol Forte resulted in a significant increase in the plasma concentration of lovastatin acid. These findings suggest that the use of RYR products may not have effects on the pharmacokinetics of concomitant comedications despite their effects to inhibit the activities of CYP450 enzymes and P-gp, whereas gemfibrozil affects the pharmacokinetics of lovastatin acid when used concomitantly with RYR products.

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Cites

Research works printed but not linked: 42

  1. 10.1016/S0140-6736(07)61778-4 · DOI · Paper page
  2. 1999, American Journal of Clinical Nutrition, 69, 231, 10.1093/ajcn/69.2.231 · DOI · Paper page
  3. 10.1530/eje.1.02012 · DOI
  4. 10.1186/1749-8546-1-4 · DOI
  5. 10.1097/HJR.0b013e32801da137 · DOI
  6. 10.1097/FJC.0b013e31802d3a58 · DOI
  7. 2009, P and T, 34, 313
  8. 10.1155/2012/636547 · DOI
  9. 10.4065/83.7.758 · DOI
  10. 2009, Annals of Internal Medicine, 150, 830, 10.7326/0003-4819-150-12-200906160-00006 · DOI · Paper page
  11. 1980, Proceedings of the National Academy of Sciences of the United States of America, 77, 3957, 10.1073/pnas.77.7.3957 · DOI · Paper page
  12. 10.1016/0003-9861(91)90551-S · DOI
  13. 10.1124/dmd.104.002477 · DOI
  14. 10.1016/j.amjcard.2009.08.672 · DOI · Paper page
  15. 10.1016/j.amjcard.2009.10.045 · DOI
  16. 2002, Transplantation, 74, 1200, 10.1097/00007890-200210270-00028 · DOI
  17. 10.1097/01.SMJ.0000100117.79718.DC · DOI
  18. 2006, Annals of Internal Medicine, 145, 474, 10.7326/0003-4819-145-6-200609190-00021 · DOI
  19. 2008, Annals of Internal Medicine, 149, 516, 10.7326/0003-4819-149-7-200810070-00021 · DOI
  20. 1986, Journal of Chromatography, 383, 438
  21. 10.1124/dmd.32.6.647 · DOI · Paper page
  22. 10.1016/j.jpba.2007.02.034 · DOI
  23. 10.1124/dmd.105.008615 · DOI · Paper page
  24. 10.1055/s-2007-967172 · DOI
  25. 10.2165/00003088-200746080-00005 · DOI
  26. 2004, Current Hypertension Reports, 6, 300, 10.1007/s11906-004-0025-5 · DOI
  27. 10.1067/mcp.2001.115542 · DOI
  28. 10.1016/j.clpt.2006.09.003 · DOI · Paper page
  29. 10.2165/00003088-200847070-00003 · DOI
  30. 2003, Journal of Clinical Pharmacology, 43, 443, 10.1177/0091270003252519 · DOI · Paper page
  31. 10.1080/00498250802017715 · DOI
  32. 1993, American Journal of Hypertension, 6, 688, 10.1093/ajh/6.8.688 · DOI
  33. 10.1038/clpt.2008.195 · DOI · Paper page
  34. 10.1177/0091270011436344 · DOI
  35. 2002, Annals of Pharmacotherapy, 36, 288, 10.1345/aph.1A289 · DOI · Paper page
  36. 10.1046/j.1365-2125.2003.01833.x · DOI · Paper page
  37. 10.1124/jpet.104.068536 · DOI · Paper page
  38. 10.1007/s00228-002-0436-7 · DOI
  39. 10.1124/dmd.109.029132 · DOI · Paper page
  40. 10.1002/bdd.1795 · DOI
  41. 10.1056/NEJMoa0809171 · DOI · Paper page
  42. 10.1517/17425250903386251 · DOI

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Metadata

Authors
Chen, C.-H., Uang, Y.-S., Wang, S.-T., Yang, J.-C., & Lin, C.-J.
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-10
ISSN
  • 1741-427X
  • 1741-4288
DOI
10.1155/2012/127043
Cited by
27
References
2
Language
en
Licence
creativecommons.org/licenses/by/3.0/ (unspecified)
Funders
National Science Council (NSC 99-3114-B-002-001)

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.