Cited by 53Schizophrenia research and treatmentMental Health and PsychiatryMental Health and Patient Involvement

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Health-Related Quality of Life and Overall Life Satisfaction in People with Serious Mental Illness

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Barnes, Amy L., Murphy, Meghan E., Fowler, Christopher A., Rempfer, Melisa V.·2012·Schizophrenia Research and Treatment

Abstract

Quality of life (QoL) in people with schizophrenia and other serious mental illnesses (SMI) is an important outcome goal, yet there is no consistent definition of the construct. We examined three aspects of QoL in persons with SMI: overall life satisfaction, physical health-related QoL (HRQoL), and mental HRQoL. This study had two primary aims: first, to examine whether there are differences in physical and mental HRQoL in persons with SMI, and, second, to investigate the cognitive, clinical, and functional correlates of the three QoL indicators. Participants were 48 persons with SMI who completed assessments of QoL, cognition, functional capacity, psychiatric symptomatology, and medical comorbidity. Results indicate that participants experience similar levels of physical and mental HRQoL, and these two constructs are not related to one another. Physical HRQoL is associated with less medical comorbidity, while mental HRQoL is associated with negative and depressive symptoms. Overall life satisfaction was associated with fewer psychiatric symptoms and less medical comorbidity. This study adds to the important literature defining distinct domains of QoL and supports the necessity of addressing both physical and mental health factors as they relate to recovery and well-being among persons with SMI.

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Metadata

Authors
Barnes, A. L., Murphy, M. E., Fowler, C. A., & Rempfer, M. V.
Affiliations
University of Missouri–Kansas City (US)
Corresponding author
Rempfer, Melisa V.
Venue
Schizophrenia Research and Treatment
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-6
ISSN
  • 2090-2085 (ISSN-L)
  • 2090-2093
OpenAlex
W2171331473
Cited by
53
References
1
Citations by year
2026: 2 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 1 · 2013: 2
FWCI
1.37
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Research and Treatment (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Missouri
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Health Professions › General Health Professions › Mental Health and Patient Involvement
Keywords
health-related quality of life, life satisfaction, severe mental illness, schizophrenia, physical health-related quality of life, mental health-related quality of life, comorbidities, depressive symptoms, psychiatric symptoms, functional capacity, cognition, well-being

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CoChat. (2026). Citation check: Health-Related Quality of Life and Overall Life Satisfaction in People with Serious Mental Illness. https://app.cochat.ai/papers/10.1155/2012/245103
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Barnes, A. L., Murphy, M. E., Fowler, C. A., & Rempfer, M. V. (2012). Health-Related Quality of Life and Overall Life Satisfaction in People with Serious Mental Illness. Schizophrenia Research and Treatment. https://doi.org/10.1155/2012/245103