Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction: Results of the Survival and Ventricular Enlargement Trial

Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445

A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Woolf, B., Robison, K., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 2,485

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453

A Human Homolog of Angiotensin-converting Enzyme

Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,041

Angiotensin-converting enzyme 2 is an essential regulator of heart function

Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733

Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase

Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

Sadoshima, J.-I., Xu, Y., Slayter, H. S., & Izumo, S. (1993) · Cell · doi:10.1016/0092-8674(93)90541-w · Cited by 1,348

Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.

Daemen, M. J. A. P., Lombardi, D. M., Bosman, F. T., & Schwartz, S. M. (1991) · Circulation Research · doi:10.1161/01.res.68.2.450 · Cited by 738

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

Huang, K., Lin, M., Kuo, T., Chen, C., Lin, C., Chou, Y., Chao, T., Pang, Y.-H., Kao, H., Huang, R., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012828 · Cited by 55

Electrochemical sensing: A prognostic tool in the fight against COVID-19

Kotru, S., Klimuntowski, M., Ridha, H., Uddin, Z., Askhar, A. A., Singh, G., & Howlader, M. M. R. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2021.116198 · Cited by 57

Allium sativum derived carbon dots as a potential theranostic agent to combat the COVID-19 crisis

Kalkal, A., Allawadhi, P., Pradhan, R., Khurana, A., Bharani, K. K., & Packirisamy, G. (2021) · Sensors International · doi:10.1016/j.sintl.2021.100102 · Cited by 57

Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your Immune Response

Châari, A., Bendriss, G., Zakaria, D., & McVeigh, C. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00476 · Cited by 62

Diseases with health disparities as drivers of COVID‐19 outcome

Moore, J. T., Pilkington, W. F., & Kumar, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15599 · Cited by 55

Cardiac injury is associated with severe outcome and death in patients with Coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of observational studies

Parohan, M., Yaghoubi, S., & Seraji, A. (2020) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872620937165 · Cited by 53

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney

Jiang, X., Eales, J., Scannali, D., Nazgiewicz, A., Prestes, P. R., Maier, M. C., Denniff, M. J., Xu, X., Saluja, S., Cano-Gamez, E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa794 · Cited by 53

The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review

Rodrigues, R., & Costa‐de‐Oliveira, S. (2021) · Microorganisms · doi:10.3390/microorganisms9081692 · Cited by 56

Coronavirus Disease 2019: The Role of the Fibrinolytic System from Transmission to Organ Injury and Sequelae

Kwaan, H. C. (2020) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1709996 · Cited by 51

Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

Lega, S., Naviglio, S., Volpi, S., & Tommasini, A. (2020) · Vaccines · doi:10.3390/vaccines8020224 · Cited by 56

IL-6 modulation for COVID-19: the right patients at the right time?

Ascierto, P. A., Fu, B., & Wei, H. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002285 · Cited by 50

Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection

Hashemi, S. M. A., Thijssen, M., Hosseini, S. Y., Tabarraei, A., Pourkarim, M. R., & Sarvari, J. (2021) · Archives of Virology · doi:10.1007/s00705-021-05070-6 · Cited by 56

Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality

Wehbe, Z., Hammoud, S. H., Yassine, H. M., Fardoun, M., EL‐Yazbi, A. F., & Eid, A. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659339 · Cited by 54

Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection

Chang, T., Yang, J., Deng, H., Chen, D., Yang, X., & Tang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843342 · Cited by 57

The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective

Kwaan, H. C., & Lindholm, P. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031283 · Cited by 50

Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19

Malinowska, B., Baranowska‐Kuczko, M., Kicman, A., & Schlicker, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041986 · Cited by 50

Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration

Dolatshahi, M., Sabahi, M., & Aarabi, M. H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02236-2 · Cited by 51

Putative Role of Vitamin D for COVID-19 Vaccination

Chiu, S.-K., Tsai, K., Wu, C., Zheng, C., Yang, C., Hu, W., Hou, Y., Lu, K., & Chao, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168988 · Cited by 50

Bioactive peptides on endothelial function

Chakrabarti, S., & Wu, J. (2015) · Food Science and Human Wellness · doi:10.1016/j.fshw.2015.11.004 · Cited by 48

Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2

Liao, W., Bhullar, K. S., Chakrabarti, S., Davidge, S. T., & Wu, J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03501 · Cited by 48

COVID‐19 and renin‐angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) ‐ Is there any scientific evidence for controversy?

Aleksova, A., Ferro, F., Gagno, G., Cappelletto, C., Santon, D., Rossi, M., Ippolito, G., Zumla, A. I., Beltrami, A. P., & Sinagra, G. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13101 · Cited by 48

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19

Moustafa, J. S. E.-S., Jackson, A., Brotman, S. M., Guan, L., Villicaña, S., Roberts, A. L., Zito, A., Bonnycastle, L. L., Erdos, M. R., Narisu, N., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01136-w · Cited by 48

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Chen, Y., Sun, L., Ullah, I., Beaudoin-Bussières, G., Anand, S. P., Hederman, A. P., Tolbert, W. D., Sherburn, R. T., Nguyen, D. N. P., Marchitto, L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn4188 · Cited by 49

A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality

Smart, L., Fawkes, N., Goggin, P., Pennick, G., Rainsford, K. D., Charlesworth, B. R., & Shah, N. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00745-z · Cited by 48

Coronavirus disease 2019 (COVID‐19) update: From metabolic reprogramming to immunometabolism

Rudiansyah, M., Jasim, S. A., pour, Z. G. M., Athar, S. S., Jeda, A. S., Doewes, R. I., Jalil, A. T., Bokov, D. O., Mustafa, Y. F., Noroozbeygi, M., et al. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27929 · Cited by 47

Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies

Pathangey, G., Fadadu, P., Hospodar, A. R., & Abbas, A. E. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00259.2020 · Cited by 48

Mechanisms contributing to adverse outcomes of COVID-19 in obesity

Sudhakar, M., Beaula, W. S., Meiyazhagan, G., & Parvathi, V. D. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04356-w · Cited by 50

Mutational analysis of structural proteins of SARS-CoV-2

Jakhmola, S., Indari, O., Kashyap, D., Varshney, N., Das, A., Manivannan, E., & Jha, H. C. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06572 · Cited by 48

Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study

Kouhpayeh, H. R., Tabasi, F., Dehvari, M., Naderi, M., Bahari, G., Khalili, T., Clark, C. J., Ghavami, S., & Taheri, M. (2021) · Translational Medicine Communications · doi:10.1186/s41231-021-00106-0 · Cited by 46

COVID-19 in patients with heart failure: the new and the old epidemic

Sisti, N., Valente, S., Mandoli, G. E., Santoro, C., Sciaccaluga, C., Franchi, F., Cameli, P., Mondillo, S., & Cameli, M. (2020) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2020-138080 · Cited by 44

The potential role of the carotid body in COVID-19

Porzionato, A., Emmi, A., Stocco, E., Barbon, S., Rafael Boscolo-berto, A., Macchi, V., & De, R. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00309.2020 · Cited by 44

Investigation of nutritional and functional effects of rice bran protein hydrolysates by using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines: A review

Gong, X., Sui, L., Morton, J. D., Brennan, M. A., & Brennan, C. S. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.01.089 · Cited by 44

Association of ACE inhibitors and angiotensin type II blockers with ACE2 overexpression in COVID-19 comorbidities: A pathway-based analytical study

Parit, R., & Jayavel, S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173899 · Cited by 43

Review of COVID‐19 and male genital tract

Hesari, F. S., Hosseinzadeh, S. S., & Sardroud, M. A. A. M. (2020) · Andrologia · doi:10.1111/and.13914 · Cited by 43

Cardiac Injury Patterns and Inpatient Outcomes Among Patients Admitted With COVID-19

Raad, M., Dabbagh, M. F., Gorgis, S., Yan, J., Chehab, O., Dagher, C., Jamoor, K., Hussein, I. H., Cook, B. C., Harn, M. V., et al. (2020) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2020.07.040 · Cited by 42

Neurological and Neuropsychological Changes Associated with SARS-CoV-2 Infection: New Observations, New Mechanisms

Haidar, M. A., Jourdi, H., Hassan, Z. H., Ashekyan, O., Fardoun, M., Wehbe, Z., Maaliki, D. S., Wehbe, M., Mondello, S., Abdelhady, S., et al. (2021) · The Neuroscientist · doi:10.1177/1073858420984106 · Cited by 44

ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID‐19

Rezaei, M. S., Ziai, S. A., Fakhri, S., & Pouriran, R. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30041 · Cited by 40

COVID-19: A Redox Disease—What a Stress Pandemic Can Teach Us About Resilience and What We May Learn from the Reactive Species Interactome About Its Treatment

Cumpstey, A. F., Clark, A. D., Santolini, J., Jackson, A. A., & Feelisch, M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0017 · Cited by 40

The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city

Zhang, S., Wang, X., Zhang, H., Ai-hui, X., Fei, G., Jiang, X., Tu, J., Qu, G., Xu, X., & Li, Y. (2020) · Reproductive Toxicology · doi:10.1016/j.reprotox.2020.06.006 · Cited by 39

Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies

Abubakar, M. B., Usman, D., Batiha, G. E., Martins, N. A., Malami, I., Ibrahim, K. G., Abubakar, B., Bello, M. B., Muhammad, A. I., Gan, S. H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.629935 · Cited by 38

COVID-19 Immunobiology: Lessons Learned, New Questions Arise

Kaklamanos, A., Belogiannis, K., Skendros, P., Gorgoulis, V. G., Vlachoyiannopoulos, P. G., & Tzioufas, A. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.719023 · Cited by 37

Mega doses of retinol: A possible immunomodulation in Covid‐19 illness in resource‐limited settings

Midha, I. K., Kumar, N., Kumar, A., & Madan, T. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2204 · Cited by 38

Renin angiotensin aldosterone system in pulmonary fibrosis: Pathogenesis to therapeutic possibilities

Gupta, D., Kumar, A., Mandloi, A. S., & Shenoy, V. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105924 · Cited by 39

Mortality and Severity in COVID-19 Patients on ACEIs and ARBs—A Systematic Review, Meta-Analysis, and Meta-Regression Analysis

Singh, R., Rathore, S. S., Khan, H., Bhurwal, A., Sheraton, M., Ghosh, P., Anand, S., Makadia, J., Ayesha, F., Mahapure, K. S., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.703661 · Cited by 38

The Role of Indoor Plants in air Purification and Human Health in the Context of COVID-19 Pandemic: A Proposal for a Novel Line of Inquiry

El-Tanbouly, R., Hassan, Z., & El-Messeiry, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.709395 · Cited by 44

COVID-19 and Cardiovascular Disease

Varmani, S. G., Chowhan, R. K., Sharma, I., & Narang, R. (2021) · Journal of the Practice of Cardiovascular Sciences · doi:10.4103/jpcs.jpcs_21_21 · Cited by 37

Should ACE2 be given a chance in COVID-19 therapeutics: A semi-systematic review of strategies enhancing ACE2

Kaur, U., Acharya, K. K., Mondal, R., Singh, A. K., Saso, L., Chakrabarti, S., & Chakrabarti, S. S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173545 · Cited by 35

The Impact ofACEandACE2Gene Polymorphisms in Pulmonary Diseases Including COVID-19

Gintoni, I., Αδαμοπούλου, Μ., & Yapijakis, C. (2021) · In Vivo · doi:10.21873/invivo.12672 · Cited by 36

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Hassan, S. S., Ghosh, S., Attrish, D., Choudhury, P. P., Uversky, V. N., Uhal, B. D., Lundstrom, K. H., Rezaei, N., Aljabali, A. A. A., Seyran, M., et al. (2020) · Molecules · doi:10.3390/molecules25245906 · Cited by 35

Autocrine and Paracrine Function of Angiotensin 1-7 in Tissue Repair During Hypertension

Meng, W., Zhao, W., Zhao, T., Liu, C., Chen, Y., Liu, H., & Sun, Y. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpt270 · Cited by 35

Association between COVID-19 and cardiovascular disease

Srivastava, K. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100583 · Cited by 33

The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic

Dan, S., Pant, M., & Upadhyay, S. K. (2020) · Current Pharmacology Reports · doi:10.1007/s40495-020-00239-0 · Cited by 35

The RAAS Goodfellas in Cardiovascular System

Caputo, I., Bertoldi, G., Driussi, G., Cacciapuoti, M., & Calò, L. A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216873 · Cited by 36

The Renin–Angiotensin–Aldosterone System (RAAS): Beyond Cardiovascular Regulation

Valentini, A., Heilmann, R. M., Kühne, A., Biagini, L., Bellis, D. D., & Rossi, G. (2025) · Veterinary Sciences · doi:10.3390/vetsci12080777 · Cited by 34

COVID-19-Associated Carotid Atherothrombosis and Stroke

Esenwa, C. C., Cheng, N. T., Lipsitz, E. C., Hsu, K. A., Zampolin, R. L., Gersten, A., Antoniello, D., Soetanto, A., Kirchoff-Torres, K. F., Liberman, A. L., et al. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6752 · Cited by 33

Type 1 Diabetes Mellitus in the SARS-CoV-2 Pandemic: Oxidative Stress as a Major Pathophysiological Mechanism Linked to Adverse Clinical Outcomes

Kountouri, A., Korakas, E., Ikonomidis, I., Raptis, A. E., Tentolouris, N., Dimitriadis, G., & Lambadiari, V. (2021) · Antioxidants · doi:10.3390/antiox10050752 · Cited by 33

Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19

Bilińska, K., von Bartheld, C. S., & Butowt, R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.674123 · Cited by 35

Deadly Companions: COVID-19 and Diabetes in Mexico

Singer, M. C. (2020) · Medical Anthropology · doi:10.1080/01459740.2020.1805742 · Cited by 32

Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19

Issa, H., Eid, A. H., Berry, B., Takhviji, V., Khosravi, A., Mantash, S., Nehme, R., Hallal, R., Karaki, H., Dhayni, K., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.620990 · Cited by 30

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19

Cook, J. R., & Ausiello, J. C. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09663-z · Cited by 32

Impact of glycemic control in diabetes mellitus on management of COVID-19 infection

Bhandari, S., Rankawat, G., Singh, A. P., Gupta, V. A., & Kakkar, S. (2020) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-020-00868-7 · Cited by 33

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19

Bumiller‐Bini, V., Oliveira, C. F., Carvalho, T. M., Kretzschmar, G. C., Gonçalves, L. B., Alencar, N. M., Filho, M. A. G., Beltrame, M. H., & Boldt, A. B. W. (2021) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2020-0199 · Cited by 30

SARS-CoV-2 Infection in Pregnancy: Placental Histomorphological Patterns, Disease Severity and Perinatal Outcomes

Wong, Y. P., Tan, G. C., Omar, S. Z., Mustangin, M., Singh, Y., Salker, M. S., Aziz, N. H. A., & Shafiee, M. N. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159517 · Cited by 31

Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs

Rehman, S. U., & Tabish, M. (2020) · Clinical Science · doi:10.1042/cs20200419 · Cited by 31

Target SARS-CoV-2: computation of binding energies with drugs of dexamethasone/umifenovir by molecular dynamics using OPLS-AA force field

Nayeem, S. M. A., Sohail, E. M., Ridhima, G., & Reddy, M. S. (2021) · Research on Biomedical Engineering · doi:10.1007/s42600-020-00119-y · Cited by 32

Review of potential risk groups for coronavirus disease 2019 (COVID-19)

Naveed, M., Naeem, M., Rahman, M. U., Hilal, M. G., Kakakhel, M. A., Ali, G., & Hassan, A. (2021) · New Microbes and New Infections · doi:10.1016/j.nmni.2021.100849 · Cited by 34

COVID‐19: Risk Factors Associated with Infectivity and Severity

Fadl, N., Ali, E., & Salem, T. Z. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13039 · Cited by 32

PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets Ace2 and Tmprss2 in mouse lung tissues

Ahmad, S., Wen, Y., & Irudayaraj, J. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.11.014 · Cited by 30

The effect of chronic peripheral nesfatin-1 application on blood pressure in normal and chronic restraint stressed rats: related with circulating level of blood pressure regulators

Ayada, C., Turgut, G., Turgut, S., & Güçlü, Z. (2015) · General Physiology and Biophysics · doi:10.4149/gpb_2014032 · Cited by 29

Platelets and renal failure in the SARS-CoV-2 syndrome

Taha, M., Sano, D., Hanoudi, S. N., Esber, Z., Elahi, M., Gabali, A., Chopra, T., Drăghici, S., & Samavati, L. (2020) · Platelets · doi:10.1080/09537104.2020.1817361 · Cited by 29

Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges

Ali, F. E. M., Mohammedsaleh, Z. M., Ali, M., & Ghogar, O. M. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i15.1531 · Cited by 29

Association of ACE2 Gene Variants with the Severity of COVID-19 Disease—A Prospective Observational Study

Sieńko, J., Marczak, I., Kotowski, M. J., Bogacz, A., Tejchman, K., Sieńko, M., & Kotfis, K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912622 · Cited by 29

Cardiovascular comorbidities and complications associated with coronavirus disease 2019

Mahajan, K., & Chandra, K. S. (2020) · Medical Journal Armed Forces India · doi:10.1016/j.mjafi.2020.05.004 · Cited by 28

Present cum future of SARS-CoV-2 virus and its associated control of virus-laden air pollutants leading to potential environmental threat – A global review

Mukherjee, S., Boral, S., Siddiqi, H., Mishra, A., & Meikap, B. C. (2021) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2020.104973 · Cited by 28

Cardiac surgery on patients with COVID ‐19: a systematic review and meta‐analysis

Gupta, A. K., Leslie, A., Hewitt, J. N., Kovoor, J. G., Ovenden, C. D., Edwards, S., Chan, J. C. Y., & Worthington, M. G. (2022) · ANZ Journal of Surgery · doi:10.1111/ans.17667 · Cited by 28

Biophysical characterization of the SARS-CoV-2 spike protein binding with the ACE2 receptor and implications for infectivityPreprint

Chowdhury, R., & Maranas, C. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.015891 · Cited by 28

Loss of angiotensin converting enzyme II (ACE2) accelerates the development of liver injury induced by thioacetamide

Wu, H., Chuang, Y., Huang, C.-P., & Chang, M.-H. (2017) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.17-0053 · Cited by 27

ACEIs and ARBs and Their Correlation with COVID-19: A Review

Yehualashet, A. S., & Belachew, T. F. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s264882 · Cited by 29

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

Arazi, H., Falahati, A., & Suzuki, K. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.747200 · Cited by 29

Kawasaki-like disease in children with COVID-19: A hypothesis

Amirfakhryan, H. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110117 · Cited by 26

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Bui, T. Q., Loan, H. T. P., My, T. T. A., Quang, D. T., Thuý, B. T. P., Nhan, V. D., Quý, P. T., Tất, P. V., Dao, D. Q., Trung, N. T., et al. (2020) · RSC Advances · doi:10.1039/d0ra05159d · Cited by 26

An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity

Gómez‐Zorita, S., Milton‐Laskibar, I., Arellano-García, L., González, M. A., & Portillo, M. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157975 · Cited by 27

Predictors of Renal Function Worsening in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Multicenter Observational Study

Pelaia, C., Pastori, D., Armentaro, G., Miceli, S., Cassano, V., Barbara, K., Pelaia, G., Perticone, M., Maio, R., Pignatelli, P., et al. (2021) · Nutrients · doi:10.3390/nu13082811 · Cited by 29

Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay

Chen, G., Pan, Y., Wu, T., Yao, T.-Y., Wang, W., Shen, W., Ahmed, A., Chan, S.-T., Tang, C., Huang, W., et al. (2021) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2021.09.002 · Cited by 26

Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2

Friedrich, M., Pfeifer, G., Binder, S., Aigner, A. M., Barbosa, P. V., Makert, G. R., Fertey, J., Ulbert, S., Bodem, J., König, E., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.801870 · Cited by 27

The renin–angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications

Diamond, B. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201000 · Cited by 25

Factors regulating dynamics of angiotensin-converting enzyme-2 (ACE2), the gateway of SARS-CoV-2: Epigenetic modifications and therapeutic interventions by epidrugs

Rath, S., Perikala, V., Jena, A. B., & Dandapat, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112095 · Cited by 25

Interaction of Severe Acute Respiratory Syndrome Coronavirus 2 and Diabetes

Shao, S., Yang, Q., Pan, R., Yu, X., & Chen, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.731974 · Cited by 27

Clinical outcomes of geriatric patients with COVID-19: review of one-year data

Avcı, G. U., Kanat, B. B., Suzan, V., Can, G., Korkmazer, B., Karaali, R., Tabak, F., Börekçi, Ş., Aygün, G., Yavuzer, H., et al. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-02047-y · Cited by 24

The impact of ACE2 polymorphisms (rs1978124, rs2285666, and rs2074192) and ACE1 rs1799752 in the mortality rate of COVID-19 in different SARS-CoV-2 variants

Sheikhian, F., Mofrad, S. S., Tarashi, S., Jajin, M. G., Sakhaee, F., Ahmadi, I., Anvari, E., Sheikhpour, M., & Fateh, A. (2023) · Human Genomics · doi:10.1186/s40246-023-00501-8 · Cited by 24

Coronavirus disease 2019 and the cardiovascular system: Impacts and implications

Gupta, M. D., Girish, M. P., Yadav, G., Shankar, A., & Yadav, R. K. (2020) · Indian Heart Journal · doi:10.1016/j.ihj.2020.03.006 · Cited by 23

Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19

Ježová, D., Karailiev, P., Karailievova, L., Puhova, A., & Murck, H. (2021) · Nutrients · doi:10.3390/nu13072321 · Cited by 23

Lineage-specific positive selection on ACE2 contributes to the genetic susceptibility of COVID-19

Pan, Y., Liu, P., Wang, F., Wu, P., Cheng, F., Jin, X., & Xu, S. (2022) · National Science Review · doi:10.1093/nsr/nwac118 · Cited by 21

Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein

Pipitò, L., Rujan, R., Reynolds, C. A., & Deganutti, G. (2022) · BioEssays · doi:10.1002/bies.202200060 · Cited by 19

The paradigm of prophylactic viral outbreaks measures by microbial biosurfactants

Kumari, K., Nandi, A., Sinha, A., Ghosh, A., Sengupta, S., Saha, U., Singh, P. K., Panda, P. K., Raina, V., & Verma, S. K. (2023) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2023.02.016 · Cited by 23

The chest CT features of coronavirus disease 2019 (COVID-19) in China: a meta-analysis of 19 retrospective studies

Yang, H., Lan, Y., Yao, X., Lin, S., & Xie, B. (2020) · Virology Journal · doi:10.1186/s12985-020-01432-9 · Cited by 22

Membrane-anchored proteases in endothelial cell biology

Antalis, T., Conway, G. D., Peroutka, R. J., & Buzza, M. S. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000238 · Cited by 22

Herbal plants coordinate COVID-19 in multiple dimensions - An insight analysis for clinically applied remedies

Zhang, Y., Li, Y., Wang, X., Ren-dong, Q., Li, J., Li, T., Tian, H., Wang, Z., Liu, Y., Shao, X., et al. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.50260 · Cited by 22

Regulated Intramembrane Proteolysis of ACE2: A Potential Mechanism Contributing to COVID-19 Pathogenesis?

González, S. M., Siddik, A. B., & Su, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612807 · Cited by 23

An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019: Implications for vascular and coagulation disease associated with severe acute respiratory syndrome coronavirus infection

Devaux, C. A., & Camoin-Jau, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1042200 · Cited by 20

Review Article Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease

Tikellis, C., & Thomas, M. C. (2011)

Pharmacological Exploitation of ACE2 Mechanism

Abdilov, N. (2022) · University of Debrecen Electronic Archive (University of Debrecen)

Angiotensin‐Converting Enzyme 2: The First Decade

Clarke, N. E., & Turner, A. J. (2011) · International Journal of Hypertension · doi:10.1155/2012/307315 · Cited by 224

ACE2 as therapeutic agent

Li, Q., Grant, M. B., Richards, E. M., & Raizada, M. K. (2020) · Clinical Science · doi:10.1042/cs20200570 · Cited by 13

doi:10.1155/2012/307315 Review Article Angiotensin-Converting Enzyme 2: The First Decade

Clarke, N. E., & Turner, A. J. (2013)