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Cited by 624Renin-Angiotensin System StudiesCoagulation, Bradykinin, Polyphosphates, and AngioedemaEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease

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Tikellis, Chris, Thomas, M. C.·2012·International Journal of Peptides
DOI 10.1155/2012/256294PMC PMC3321295
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Abstract

Angiotensin-converting enzyme 2 (ACE2) shares some homology with angiotensin-converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the degradation of Ang II resulting in the formation of angiotensin 1–7 (Ang 1–7) which opposes the actions of Ang II. Increased Ang II levels are thought to upregulate ACE2 activity, and in ACE2 deficient mice Ang II levels are approximately double that of wild-type mice, whilst Ang 1–7 levels are almost undetectable. Thus, ACE2 plays a crucial role in the RAS because it opposes the actions of Ang II. Consequently, it has a beneficial role in many diseases such as hypertension, diabetes, and cardiovascular disease where its expression is decreased. Not surprisingly, current therapeutic strategies for ACE2 involve augmenting its expression using ACE2 adenoviruses, recombinant ACE2 or compounds in these diseases thereby affording some organ protection.

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  1. 2000, Circulation Research, 87, E1
  2. 2002, American Journal of Physiology, 282, H2254
  3. 1993, Circulation, 87, IV7
  4. 1994, Hypertension, 23, 869

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Metadata

Authors
Tikellis, C., & Thomas, M. C.
Affiliations
Baker Heart and Diabetes Institute (AU)
Corresponding author
Tikellis, Chris
ORCID
Thomas, M. C.
Venue
International Journal of Peptides
Publisher
Hindawi Limited
Published
2012-03-20
Volume
2012
Pages
1-8
ISSN
  • 1687-9767 (ISSN-L)
  • 1687-9775
DOI
10.1155/2012/256294
PMC
PMC3321295
OpenAlex
W2082133861
Cited by
624
References
85
Citations by year
2026: 8 · 2025: 11 · 2024: 31 · 2023: 57 · 2022: 87 · 2021: 164 · 2020: 244 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3
FWCI
1.65
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Peptides (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders
National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
angiotensin-converting enzyme 2, renin-angiotensin system, angiotensin II, angiotensin-(1-7), hypertension, diabetes mellitus, cardiovascular disease, organ protection

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