The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
Open accessAbstract
Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts.
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Cites
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Apoptosis, autophagy, necroptosis, and cancer metastasis
Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0321-5 · Cited by 1,042
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Zhao, Y., Hu, X., Liu, Y., Dong, S., Wen, Z., He, W., Zhang, S., Huang, Q., & Shi, M. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0648-1 · Cited by 735
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The functional activity of E-cadherin controls tumor cell metastasis at multiple steps
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Metadata
- Authors
- Kim, Y.-N., Koo, K. H., Sung, J. Y., Yun, U.-J., & Kim, H.
- Venue
- International Journal of Cell Biology
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-11
- ISSN
- 1687-8876 (ISSN-L)
- 1687-8884
- OpenAlex
- W2091823826
- Cited by
- 461
- References
- 109
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kim, Y.-N., Koo, K. H., Sung, J. Y., Yun, U.-J., & Kim, H. (2012). Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis. International Journal of Cell Biology. https://doi.org/10.1155/2012/306879
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