The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging
Open accessAbstract
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS function as “redox messengers” in intracellular signalling and regulation, whereas excess ROS induce cell death by promoting the intrinsic apoptotic pathway. Recent work has pointed to a further role of ROS in activation of autophagy and their importance in the regulation of aging. This review will focus on mitochondria as producers and targets of ROS and will summarize different proteins that modulate the redox state of the cell. Moreover, the involvement of ROS and mitochondria in different molecular pathways controlling lifespan will be reported, pointing out the role of ROS as a “balance of power,” directing the cell towards life or death.
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Cites
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Galadari, S., Rahman, A., Pallichankandy, S., & Thayyullathil, F. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.004 · Cited by 893
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The endoplasmic reticulum–mitochondria connection: One touch, multiple functions
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Self-citationThe Mitochondrial Basis of Aging and Age-Related Disorders
Srivastava, S. (2017) · Genes · doi:10.3390/genes8120398 · Cited by 420
Metadata
- Authors
- Marchi, S., Giorgi, C., Suski, J. M., Agnoletto, C., Bononi, A., Bonora, M., De Marchi, E., Missiroli, S., Patergnani, S., Poletti, F., Rimessi, A., Duszynski, J., Wieckowski, M. R., & Pinton, P.
- Venue
- Journal of Signal Transduction
- Publisher
- Wiley
- Published
- 2012-11-14
- Volume
- 2012
- Pages
- 1-17
- ISSN
- 2090-1739 (ISSN-L)
- 2090-1747
- OpenAlex
- W2115788076
- Cited by
- 640
- References
- 214
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Marchi, S., Giorgi, C., Suski, J. M., Agnoletto, C., Bononi, A., Bonora, M., De Marchi, E., Missiroli, S., Patergnani, S., Poletti, F., Rimessi, A., Duszynski, J., Wieckowski, M. R., & Pinton, P. (2012). Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging. Journal of Signal Transduction. https://doi.org/10.1155/2012/329635
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