Metformin as adjunct antituberculosis therapy

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Mihaylova, M. M., & Shaw, R. J. (2011) · Nature Cell Biology · doi:10.1038/ncb2329 · Cited by 2,923 · see citing works

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252 · see citing works

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157 · see citing works

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898 · see citing works

Cellular and molecular mechanisms of metformin: an overview

Viollet, B., Guigas, B., Garcia, N. S., Leclerc, J., Foretz, M., & Andreelli, F. (2012) · Clinical Science · doi:10.1042/cs20110386 · Cited by 1,720 · see citing works

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559 · see citing works

Cell-Mediated Immune Responses in Tuberculosis

Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,173 · see citing works

Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation

O'Neill, L. A. J., & Hardie, D. G. (2013) · Nature · doi:10.1038/nature11862 · Cited by 1,133 · see citing works

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Wheaton, W. W., Weinberg, S. E., Hamanaka, R. B., Soberanes, S., Sullivan, L. B., Anso, E., Glasauer, A., Dufour, E., Mutlu, G. M., Budigner, G. S., et al. (2014) · eLife · doi:10.7554/elife.02242 · Cited by 1,105 · see citing works

Unveiling the roles of autophagy in innate and adaptive immunity

Levine, B., & Deretic, V. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2161 · Cited by 903 · see citing works

Advances in the development of new tuberculosis drugs and treatment regimens

Zumla, A. I., Nahid, P., & Cole, S. T. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4001 · Cited by 895 · see citing works

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

Salminen, A., Hyttinen, J. M. T., & Kaarniranta, K. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0748-0 · Cited by 866 · see citing works

PAGE: Parametric Analysis of Gene Set Enrichment

Kim, S., & Volsky, D. J. (2005) · BMC Bioinformatics · doi:10.1186/1471-2105-6-144 · Cited by 781 · see citing works

Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

Marchi, S., Giorgi, C., Suski, J. M., Agnoletto, C., Bononi, A., Bonora, M., Marchi, E. D., Missiroli, S., Patergnani, S., Poletti, F., et al. (2011) · Journal of Signal Transduction · doi:10.1155/2012/329635 · Cited by 639 · see citing works

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Ejim, L., Farha, M. A., Falconer, S. B., Wildenhain, J., Coombes, B. K., Tyers, M., Brown, E. D., & Wright, G. D. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.559 · Cited by 525 · see citing works

Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy?

Behar, S. M., Divangahi, M., & Remold, H. G. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2387 · Cited by 427 · see citing works

Molecular Epidemiology of Tuberculosis: Current Insights

Mathema, B., Kurepina, N. E., Bifani, P. J., & Kreiswirth, B. N. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00061-05 · Cited by 411 · see citing works

Chemical modulators of autophagy as biological probes and potential therapeutics

Fleming, A., Noda, T., Yoshimori, T., & Rubinsztein, D. C. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.500 · Cited by 347 · see citing works

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis

Kumar, D., Nath, L., Kamal, M. A., Varshney, A., Jain, A., Singh, S., & Rao, K. V. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.012 · Cited by 345 · see citing works

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

Kuijl, C. P., Savage, N. D. L., Marsman, M., Tuin, A. W., Janssen, L., Egan, D. A., Ketema, M., van den Nieuwendijk, R., van den Eeden, S. J. F., Geluk, A., et al. (2007) · Nature · doi:10.1038/nature06345 · Cited by 300 · see citing works

Host Innate Immune Response to Mycobacterium tuberculosis

Bhatt, K., & Salgame, P. R. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9084-0 · Cited by 220 · see citing works

Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis

Vilaplana, C., Marzo, E., Tapia, G., Diaz, J., Garcia, V., & Cardona, P.-J. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit152 · Cited by 220 · see citing works

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

Willand, N., Dirié, B., Carette, X., Bifani, P. J., Singhal, A., Desroses, M., Leroux, F., Willery, E., Mathys, V., Deprez-Poulain, R. F., et al. (2009) · Nature Medicine · doi:10.1038/nm.1950 · Cited by 179 · see citing works

Evasion and subversion of antigen presentation by Mycobacterium tuberculosis

Baena, A., & Porcelli, S. A. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01301.x · Cited by 146 · see citing works

Estimating the starting dose for entry into humans: principles and practice

Reigner, B. G., & Blesch, K. S. (2002) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-001-0405-6 · Cited by 132 · see citing works

Host-Directed Drug Targeting of Factors Hijacked by Pathogens

Schwegmann, A., & Brombacher, F. (2008) · Science Signaling · doi:10.1126/scisignal.129re8 · Cited by 128 · see citing works

Bacillus Calmette Guerin Vaccination of Human Newborns Induces a Specific, Functional CD8+ T Cell Response

Murray, R. A., Mansoor, N., Harbacheuski, R., Soler, J., Davids, V., Soares, A. P., Hawkridge, A., Hussey, G. D., Maecker, H. T., Kaplan, G., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5647 · Cited by 100 · see citing works

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

Subbian, S., Tsenova, L., O’Brien, P. E., Yang, G., Koo, M.-S., Peixoto, B., Fallows, D. A., Dartois, V. A., Muller, G. W., & Kaplan, G. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002262 · Cited by 94 · see citing works

Double‐ and monofunctional CD4+ and CD8+ T‐cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long‐term latently infected individuals

Commandeur, S., Lin, M. Y., van Meijgaarden, K. E., Friggen, A. H., Franken, K. L. M. C., Drijfhout, J. W., Korsvold, G. E., Oftung, F., Geluk, A., & Ottenhoff, T. H. M. (2011) · European Journal of Immunology · doi:10.1002/eji.201141602 · Cited by 90 · see citing works

Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology

Subbian, S., Tsenova, L., O’Brien, P. E., Yang, G., Koo, M.-S., Peixoto, B., Fallows, D. A., Zeldis, J. B., Muller, G. W., & Kaplan, G. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.039 · Cited by 89 · see citing works

Comparative Analysis of T Lymphocytes Recovered from the Lungs of Mice Genetically Susceptible, Resistant, and Hyperresistant to Mycobacterium tuberculosis -Triggered Disease

Lyadova, I. V., Eruslanov, E. B., Khaidukov, S. V., Yeremeev, V., Majorov, K. B., Pichugin, A. V., Nikonenko, B. V., Kondratieva, T. K., & Apt, A. S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.10.5921 · Cited by 76 · see citing works

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

Koo, M.-S., Manca, C., Yang, G., O’Brien, P. E., Sung, N., Tsenova, L., Subbian, S., Fallows, D. A., Muller, G. W., Ehrt, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017091 · Cited by 75 · see citing works

Adjunct Immunotherapies for Tuberculosis

Uhlin, M., Andersson, J., Zumla, A. I., & Maeurer, M. J. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis197 · Cited by 75 · see citing works

The Co-Management of Tuberculosis and Diabetes: Challenges and Opportunities in the Developing World

Sullivan, T., & Amor, Y. B. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001269 · Cited by 71 · see citing works

Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice

Chackerian, A. A., & Behar, S. M. (2003) · Tuberculosis · doi:10.1016/s1472-9792(03)00017-9 · Cited by 68 · see citing works

Adjuvant Host-Directed Therapy with Types 3 and 5 but Not Type 4 Phosphodiesterase Inhibitors Shortens the Duration of Tuberculosis Treatment

Maïga, M., Ammerman, N. C., Maiga, M. C., Tounkara, A., Siddiqui, S., Polis, M., Murphy, R. L., & Bishai, W. R. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit187 · Cited by 56 · see citing works

Molecular Epidemiology ofMycobacterium tuberculosisin a South African Community with High HIV Prevalence

Middelkoop, K., Bekker, L., Mathema, B., Shashkina, E., Kurepina, N. E., Whitelaw, A. C., Fallows, D. A., Morrow, C. D., Kreiswirth, B. N., Kaplan, G., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/605930 · Cited by 54 · see citing works

Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis

Jacobsen, M., Detjen, A., Mueller, H., Gutschmidt, A., Schommer-Leitner, S., Wahn, U., Magdorf, K., & Kaufmann, S. H. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1331 · Cited by 44 · see citing works

Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances

Kumar, D., & Rao, K. V. S. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.10.009 · Cited by 39 · see citing works

Setting new targets in the fight against tuberculosis

Raviglione, M. C., & Diţiu, L. (2013) · Nature Medicine · doi:10.1038/nm.3129 · Cited by 28 · see citing works

Rational Development of Adjunct Immune-Based Therapies for Drug-Resistant Tuberculosis: Hypotheses and Experimental Designs

Zumla, A. I., & Maeurer, M. J. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir881 · Cited by 22 · see citing works

Host-directed therapies against tuberculosis

Wilkinson, R. J. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70295-9 · Cited by 14 · see citing works

Ahead of WHO meeting, experts clash over tuberculosis targets

Maxmen, A. (2013) · Nature Medicine · doi:10.1038/nm0213-115 · Cited by 8 · see citing works

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Sun, L., Xie, C., Wang, G., Wu, Y., Wu, Q., Wang, X., Liu, J., Deng, Y., Xia, J., Chen, B., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0222-4 · Cited by 1,011 · see citing works

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960 · see citing works

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S.-C., Wang, S.-Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.008 · Cited by 930 · see citing works

Host-directed therapies for bacterial and viral infections

Kaufmann, S. H. E., Dorhoi, A., Hotchkiss, R. S., & Bartenschlager, R. F. W. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.162 · Cited by 847 · see citing works

Metformin: update on mechanisms of action and repurposing potential

Foretz, M., Guigas, B., & Viollet, B. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00833-4 · Cited by 744 · see citing works

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Foretz, M., Guigas, B., & Viollet, B. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0242-2 · Cited by 686 · see citing works

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

Zumla, A. I., Rao, M., Wallis, R. S., Kaufmann, S. H. E., Rustomjee, R., Mwaba, P., Vilaplana, C., Yeboah‐Manu, D., Chakaya, J. M., Ippolito, G., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00078-5 · Cited by 408 · see citing works

Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies

Tiberi, S., du Plessis, N., Walzl, G., Vjecha, M. J., Rao, M., Ntoumi, F., Mfinanga, S., Kapata, N., Mwaba, P., McHugh, T. D., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30110-5 · Cited by 403 · see citing works

Mitochondrial control of immunity: beyond ATP

Mehta, M., Weinberg, S. E., & Chandel, N. S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.66 · Cited by 400 · see citing works

Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

Brown, D. L. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4675 · Cited by 360 · see citing works

Advancing host-directed therapy for tuberculosis

Wallis, R. S., & Hafner, R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3813 · Cited by 291 · see citing works

Metformin: Is it a drug for all reasons and diseases?

Triggle, C. R., Mohammed, I., Bshesh, K., Marei, I., Ye, K., Ding, H., MacDonald, R. S., Hollenberg, M. D., & Hill, M. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155223 · Cited by 282 · see citing works

Host-directed immunotherapy of viral and bacterial infections: past, present and future

Wallis, R. S., O’Garra, A., Sher, A., & Wack, A. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00734-z · Cited by 268 · see citing works

Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers

Wallis, R. S., Maeurer, M. J., Mwaba, P., Chakaya, J. M., Rustomjee, R., Migliori, G. B., Marais, B. J., Schito, M. L., Churchyard, G., Swaminathan, S., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00070-0 · Cited by 271 · see citing works

Metformin Restores Tetracyclines Susceptibility against Multidrug Resistant Bacteria

Liu, Y., Jia, Y., Yang, K., Li, R., Xiao, X., Zhu, K., & Wang, Z. (2020) · Advanced Science · doi:10.1002/advs.201902227 · Cited by 242 · see citing works

Metabolic crosstalk between host and pathogen: sensing, adapting and competing

Olive, A. J., & Sassetti, C. M. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.12 · Cited by 228 · see citing works

Metformin attenuates lung fibrosis development via NOX4 suppression

Sato, N., Takasaka, N., Yoshida, M., Tsubouchi, K., Minagawa, S., Araya, J., Saito, N., Fujita, Y., Kurita, Y., Kobayashi, K., et al. (2016) · Respiratory Research · doi:10.1186/s12931-016-0420-x · Cited by 229 · see citing works

Diabetes and Tuberculosis

Restrepo, B. I. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tnmi7-0023-2016 · Cited by 233 · see citing works

Therapeutic host-directed strategies to improve outcome in tuberculosis

Young, C., Walzl, G., & du Plessis, N. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0226-5 · Cited by 202 · see citing works

Diabetes and Lung Disease: An Underestimated Relationship

Khateeb, J., Fuchs, E., & Khamaisi, M. (2019) · The Review of Diabetic Studies · doi:10.1900/rds.2019.15.1 · Cited by 200 · see citing works

The Cellular and Molecular Basis of Translational Immunometabolism

Norata, G. D., Caligiuri, G., Chavakis, T., Matarese, G., Netea, M. G., Nicoletti, A., O'Neill, L. A. J., & Marelli‐Berg, F. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.023 · Cited by 193 · see citing works

The double burden of diabetes and global infection in low and middle-income countries

Dunachie, S. J., & Chamnan, P. (2018) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/try124 · Cited by 195 · see citing works

Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management

Liebenberg, D., Gordhan, B. G., & Kana, B. D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.943545 · Cited by 210 · see citing works

Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport

Roca, F. J., Whitworth, L. J., Prag, H. A., Murphy, M. P., & Ramakrishnan, L. (2022) · Science · doi:10.1126/science.abh2841 · Cited by 177 · see citing works

Macrophage Autophagy and Bacterial Infections

Bah, A., & Vergne, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01483 · Cited by 166 · see citing works

The global diabetes epidemic: what does it mean for infectious diseases in tropical countries?

van Crevel, R., van de Vijver, S. J. M., & Moore, D. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30081-x · Cited by 156 · see citing works

Inducible antibacterial responses in macrophages

Sweet, M. J., Ramnath, D., Singhal, A., & Kapétanovic, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01080-y · Cited by 163 · see citing works

Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control

Scheen, A. J., Esser, N., & Paquot, N. (2015) · Diabetes & Metabolism · doi:10.1016/j.diabet.2015.02.003 · Cited by 155 · see citing works

Host‐directed therapy to combat mycobacterial infections*

Kilinç, G., Saris, A., Ottenhoff, T. H. M., & Haks, M. C. (2021) · Immunological Reviews · doi:10.1111/imr.12951 · Cited by 144 · see citing works

Metformin Use Reverses the Increased Mortality Associated With Diabetes Mellitus During Tuberculosis Treatment

Degner, N. R., Wang, J., Golub, J. E., & Karakousis, P. C. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix819 · Cited by 136 · see citing works

Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis

Ndlovu, H., & Marakalala, M. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00434 · Cited by 137 · see citing works

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

Cheng, C. Y., Gutierrez, N. M., Marzuki, M., Lu, X., Foreman, T. W., Paleja, B. S., Lee, B. T. K., Balachander, A., Chen, J., Tsenova, L., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aaj1789 · Cited by 133 · see citing works

Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections

Gauthier, T., & Chen, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.780839 · Cited by 134 · see citing works

The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications

Luies, L., & du Preez, I. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00036-20 · Cited by 181 · see citing works

Host-directed therapy targeting the Mycobacterium tuberculosis granuloma: a review

Kiran, D., Podell, B. K., Chambers, M. A., & Basaraba, R. J. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0537-x · Cited by 129 · see citing works

Immunometabolism during Mycobacterium tuberculosis Infection

Howard, N. C., & Khader, S. A. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.04.010 · Cited by 132 · see citing works

Transient Hyperglycemia in Patients With Tuberculosis in Tanzania: Implications for Diabetes Screening Algorithms

Boillat‐Blanco, N., Ramaiya, K. L., Mganga, M., Minja, L. T., Bovet, P., Schindler, C., von Eckardstein, A., Gagneux, S., Daubenberger, C., Reither, K., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv568 · Cited by 121 · see citing works

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

Lachmandas, E., Eckold, C., Böhme, J., Koeken, V. A. C. M., Marzuki, M., Blok, B. A., Arts, R. J. W., Chen, J., Teng, K. W. W., Ratter, J. M., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz064 · Cited by 122 · see citing works

Glycemic Control and the Risk of Tuberculosis: A Cohort Study

Lee, P.-H., Fu, H. J., Lai, T.-C., Chiang, C., Chan, C., & Lin, H.-H. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002072 · Cited by 120 · see citing works

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

Giraud-Gatineau, A., Coya, J. M., Maure, A., Biton, A., Thomson, M., Bernard, E. M., Marrec, J., Gutierrez, M. G., Larrouy-Maumus, G. J., Brosch, R., et al. (2020) · eLife · doi:10.7554/elife.55692 · Cited by 111 · see citing works

Inflammation-mediated tissue damage in pulmonary tuberculosis and host-directed therapeutic strategies

Tiwari, D., & Martineau, A. R. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101672 · Cited by 111 · see citing works

Acquired immunodeficiencies and tuberculosis: focus on HIV / AIDS and diabetes mellitus

Ronacher, K., Joosten, S. A., van Crevel, R., Dockrell, H. M., Walzl, G., & Ottenhoff, T. H. M. (2015) · Immunological Reviews · doi:10.1111/imr.12257 · Cited by 106 · see citing works

High Prevalence and Heterogeneity of Diabetes in Patients With TB in South India

Kornfeld, H., West, K., Kane, K., Kumpatla, S., Zacharias, R. R., Martínez-Balzano, C., Li, W., & Viswanathan, V. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.02.675 · Cited by 106 · see citing works

The Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed Therapy

Stek, C. J., Allwood, B., Walker, N. F., Wilkinson, R. J., Lynen, L., & Meintjes, G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02603 · Cited by 102 · see citing works

Diabetes mellitus and tuberculosis: programmatic management issues

Harries, A. D., Kumar, A. M. V., Satyanarayana, S., Lin, Y., Zachariah, R., Lönnroth, K., & Kapur, A. (2015) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.15.0069 · Cited by 101 · see citing works

Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action

Goel, S. K., Singh, R. P., Singh, V., Singh, H., Kumari, P., Chopra, H., Sharma, R., Nepovimová, E., Vališ, M., Kuča, K., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1022739 · Cited by 112 · see citing works

The effects of metformin on gut microbiota and the immune system as research frontiers

Pollak, M. (2017) · Diabetologia · doi:10.1007/s00125-017-4352-x · Cited by 98 · see citing works

Protective effect of metformin against tuberculosis infections in diabetic patients: an observational study of south Indian tertiary healthcare facility

Marupuru, S., Senapati, P., Pathadka, S., Miraj, S. S., Unnikrishnan, M. K., & Manu, M. K. (2017) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2017.01.001 · Cited by 98 · see citing works

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

Penn‐Nicholson, A., Hraha, T. H., Thompson, E. G., Sterling, D., Mbandi, S. K., Wall, K. M., Fisher, M., Suliman, S., Shankar, S., Hanekom, W. A., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002781 · Cited by 96 · see citing works

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Russell, S., Lamprecht, D. A., Mandizvo, T., Jones, T., Naidoo, V., Addicott, K. W., Moodley, C., Ngcobo, B., Crossman, D. K., Wells, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.034 · Cited by 99 · see citing works

The Changing Paradigm of Drug-Resistant Tuberculosis Treatment: Successes, Pitfalls, and Future Perspectives

Dookie, N., Ngema, S. L., Perumal, R., Naicker, N., Padayatchi, N., & Naidoo, K. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00180-19 · Cited by 97 · see citing works

Host Directed Therapies for Tuberculosis: Futures Strategies for an Ancient Disease

Palucci, I., & Delogu, G. (2018) · Chemotherapy · doi:10.1159/000490478 · Cited by 99 · see citing works

Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice

Dutta, N. K., Bruiners, N., Zimmerman, M. D., Tan, S., Dartois, V. A., Gennaro, M. L., & Karakousis, P. C. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz517 · Cited by 90 · see citing works

Randomized Trial of Metformin With Anti-Tuberculosis Drugs for Early Sputum Conversion in Adults With Pulmonary Tuberculosis

Padmapriydarsini, C., Mamulwar, M., Mohan, A., Shanmugam, P., Gomathy, N. S., Mane, A., Singh, U. B., Pavankumar, N., Kadam, A., Kumar, H., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab964 · Cited by 90 · see citing works

Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics

Hélaine, S., Conlon, B. P., Davis, K. M., & Russell, D. G. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.04.019 · Cited by 89 · see citing works

Addressing diabetes mellitus as part of the strategy for ending TB

Harries, A. D., Kumar, A. M. V., Satyanarayana, S., Lin, Y., Zachariah, R., Lönnroth, K., & Kapur, A. (2016) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/trv111 · Cited by 91 · see citing works

Is metformin poised for a second career as an antimicrobial?

Malik, F. R., Mehdi, S. F., Ali, H., Patel, P., Basharat, A., Kumar, A., Ashok, F., Stein, J., Brima, W., Malhotra, P., et al. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2975 · Cited by 87 · see citing works

Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis

Chandra, P., He, L., Zimmerman, M. D., Yang, G., Köster, S., Ouimet, M. I., Wang, H., Moore, K. J., Dartois, V. A., Schilling, J. D., et al. (2020) · mBio · doi:10.1128/mbio.01139-20 · Cited by 88 · see citing works

The Interaction of Diabetes and Tuberculosis: Translating Research to Policy and Practice

van Crevel, R., & Critchley, J. (2021) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed6010008 · Cited by 90 · see citing works

AMP-Activated Protein Kinase and Host Defense against Infection

Silwal, P., Kim, J. K., Yuk, J., & Jo, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113495 · Cited by 81 · see citing works

Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis

Krug, S., Parveen, S., & Bishai, W. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660916 · Cited by 84 · see citing works

Mycobacterium tuberculosis: Pathogenesis and therapeutic targets

Yang, J.-X., Zhang, L., Qiao, W., & Luo, Y. (2023) · MedComm · doi:10.1002/mco2.353 · Cited by 80 · see citing works

Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species

Kajiwara, C., Kusaka, Y., Kimura, S., Yamaguchi, T., Nanjo, Y., Ishii, Y., Udono, H., Standiford, T. J., & Tateda, K. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700474 · Cited by 83 · see citing works

AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

Zhang, Q., Liu, S., Zhang, C., Wu, Q., Yu, X., Zhou, R., Meng, F., Wang, A., Zhang, F., Chen, S., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.10.026 · Cited by 81 · see citing works

How macrophage heterogeneity affects tuberculosis disease and therapy

Russell, D. G., Simwela, N. V., Mattila, J. T., Flynn, J. L., Mwandumba, H., & Pisu, D. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-024-01124-3 · Cited by 68 · see citing works

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Böhme, J., Martínez, N., Li, S., Lee, A., Marzuki, M., Tizazu, A. M., Ackart, D. F., Haugen, J. D., Todd, A., Lachmandas, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19095-z · Cited by 81 · see citing works

The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus

Lee, Y. J., Han, S. K., Park, J. H., Lee, J., Kim, D. K., Chung, H. S., & Heo, E. Y. (2018) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2017.249 · Cited by 78 · see citing works

Metabolic reprogramming & inflammation: Fuelling the host response to pathogens

Gleeson, L. E., & Sheedy, F. J. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.007 · Cited by 74 · see citing works

A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?

Maniar, K., Moideen, A., Mittal, A., Patil, A., Chakrabarti, A., & Banerjee, D. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.003 · Cited by 75 · see citing works

Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway

Xiao, Y., Liu, F., Li, S., Jiang, N., Yu, C., Zhu, X., Qin, Y., Hui, J., Meng, L., Song, C., et al. (2019) · Virulence · doi:10.1080/21505594.2019.1706305 · Cited by 74 · see citing works

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

Zumla, A. I., Rao, M., Dodoo, E., & Maeurer, M. J. (2016) · BMC Medicine · doi:10.1186/s12916-016-0635-1 · Cited by 73 · see citing works

Tuberculosis and diabetes: current state and future perspectives

Pizzol, D., Gennaro, F. D., Chhaganlal, K. D., Fabrizio, C., Monno, L., Putoto, G., & Saracino, A. (2016) · Tropical Medicine & International Health · doi:10.1111/tmi.12704 · Cited by 72 · see citing works

Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response

Pereira, F. V., de Melo, A. C. L., Low, J. S., de Castro, Í. A., Braga, T. T., de Almeida, D. C., de Lima, A. G. U. B., Hiyane, M. I., Corrêa-Costa, M., Andrade‐Oliveira, V., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25380 · Cited by 72 · see citing works

Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells

Mishra, A. K., & Dingli, D. (2019) · Leukemia · doi:10.1038/s41375-019-0470-4 · Cited by 71 · see citing works

Defining a Research Agenda to Address the Converging Epidemics of Tuberculosis and Diabetes

Ronacher, K., van Crevel, R., Critchley, J., Bremer, A. A., Schlesinger, L. S., Kapur, A., Basaraba, R. J., Kornfeld, H., & Restrepo, B. I. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.02.032 · Cited by 70 · see citing works

Host-Directed Therapies for Tuberculosis

Jeong, E.-K., Lee, H.-J., & Jung, Y. (2022) · Pathogens · doi:10.3390/pathogens11111291 · Cited by 74 · see citing works

Autophagy-activating strategies to promote innate defense against mycobacteria

Kim, Y. S., Silwal, P., Kim, S. Y., Yoshimori, T., & Jo, E. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0290-7 · Cited by 70 · see citing works

Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection

Vu, A., Glassman, I., Campbell, G., Yeganyan, S., Nguyen, J., Shin, A., & Venketaraman, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116255 · Cited by 70 · see citing works

Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review

Yu, X., Li, L., Xia, L., Feng, X., Chen, F., Cao, S., & Wei, X. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4548-4 · Cited by 66 · see citing works

Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation

Ahmed, S., Raqib, R., Gudmundsson, G. H., Bergman, P., Agerberth, B., & Rekha, R. S. (2020) · Antibiotics · doi:10.3390/antibiotics9010021 · Cited by 66 · see citing works

Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria

Lee, Y. J., Kim, J. K., Jung, C. H., Kim, Y. J., Jung, E. J., Lee, S. H., Choi, H. R., Son, Y. S., Shim, S. M., Jeon, S. M., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2054240 · Cited by 65 · see citing works

Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity

Kumar, N. P., Fukutani, K. F., Shruthi, B. S., Alves, T., Silveira-Mattos, P. S., Rocha, M. S., West, K., Natarajan, M., Viswanathan, V., Babu, S., et al. (2019) · eLife · doi:10.7554/elife.46477 · Cited by 66 · see citing works

Metformin: Candidate host-directed therapy for tuberculosis in diabetes and non-diabetes patients

Restrepo, B. I. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.09.008 · Cited by 63 · see citing works

Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention

Kumar, A., Alam, A., Grover, S., Pandey, S., Tripathi, D., Kumari, M., Rani, M., Singh, A., Akhter, Y., Ehtesham, N., et al. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-018-0075-0 · Cited by 53 · see citing works

Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients

Ochoa-González, F. D. L., Cervantes-Villagrana, A. R., Fernández-Ruiz, J. C., Nava-Ramirez, H. S., Hernandez-Correa, A. C., Enciso‐Moreno, J. A., & Castañeda‐Delgado, J. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150900 · Cited by 63 · see citing works

Metformin Decreases Risk of Tuberculosis Infection in Type 2 Diabetes Patients

Tseng, C. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090264 · Cited by 64 · see citing works

Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection

O’Connor, G., Krishnan, N., Fagan-Murphy, A., Cassidy, J. P., O’Leary, S. M., Robertson, B. D., Keane, J., O’Sullivan, M. P., & Cryan, S. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.10.020 · Cited by 63 · see citing works

Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs

Rodrigues, L., Cravo, P., & Viveiros, M. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1760845 · Cited by 63 · see citing works

The global dynamics of diabetes and tuberculosis: the impact of migration and policy implications

Girardi, E., Schepisi, M. S., Goletti, D., Bates, M., Mwaba, P., Yeboah‐Manu, D., Ntoumi, F., Palmieri, F., Maeurer, M. J., Zumla, A. I., et al. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.01.018 · Cited by 62 · see citing works

Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs

Chauhan, A., Kumar, M., Kumar, A., & Kanchan, K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119301 · Cited by 64 · see citing works

Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis

Vashisht, R., & Brahmachari, S. K. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0443-y · Cited by 62 · see citing works

Tuberculosis and comorbidities: treatment challenges in patients with comorbid diabetes mellitus and depression

Caceres-Cardenas, G., Calderón, R., & Ugarte‐Gil, C. (2022) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361221095831 · Cited by 80 · see citing works

The Risk of TB in Patients With Type 2 Diabetes Initiating Metformin vs Sulfonylurea Treatment

Pan, S., Yen, Y., Kou, Y. R., Chuang, P., Su, V. Y., Feng, J., Chan, Y., & Su, W. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.11.040 · Cited by 59 · see citing works

Targeting immunometabolism in host defence against Mycobacterium tuberculosis

Sheedy, F. J., & Divangahi, M. (2020) · Immunology · doi:10.1111/imm.13276 · Cited by 59 · see citing works

Repurposing Immunomodulatory Drugs to Combat Tuberculosis

Fatima, S., Bhaskar, A., & Dwivedi, V. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.645485 · Cited by 58 · see citing works

Metformin as Host-Directed Therapy for TB Treatment: Scoping Review

Naicker, N., Sigal, A., & Naidoo, K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00435 · Cited by 55 · see citing works

Understanding Metabolic Regulation Between Host and Pathogens: New Opportunities for the Development of Improved Therapeutic Strategies Against Mycobacterium tuberculosis Infection

Park, J.-H., Shim, D., Kim, K. E. S., Lee, W., & Shin, S. J. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.635335 · Cited by 56 · see citing works

Trends in the discovery of new drugs for Mycobacterium tuberculosis therapy with a glance at resistance

Lohrasbi, V., Talebi, M., Bialvaei, A. Z., Fattorini, L., Drancourt, M., Heidary, M., & Darban‐Sarokhalil, D. (2017) · Tuberculosis · doi:10.1016/j.tube.2017.12.002 · Cited by 57 · see citing works

Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria

Masadeh, M. M., Alzoubi, K. H., Masadeh, M. M., & Aburashed, Z. O. (2021) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s297903 · Cited by 55 · see citing works

Innovative Strategies for Combating Multidrug-Resistant Tuberculosis: Advances in Drug Delivery Systems and Treatment

Omoteso, O. A., Fadaka, A. O., Walker, R. B., & Khamanga, S. M. (2025) · Microorganisms · doi:10.3390/microorganisms13040722 · Cited by 63 · see citing works

Metformin: Candidate host-directed therapy for tuberculosis in diabetes and non-diabetes patients

Restrepo, B. I. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.09.008 · Cited by 63 · see citing works

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

Lachmandas, E., Eckold, C., Böhme, J., Koeken, V. A. C. M., Marzuki, M., Blok, B. A., Arts, R. J. W., Chen, J., Teng, K. W. W., Ratter, J. M., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz064 · Cited by 122 · see citing works

Metformin has immunomodulatory effects which support its potential use as adjunctive therapy in tuberculosis

Sutter, A., Landis, D. M., & NUGENT, K. M. (2023) · Indian Journal of Tuberculosis · doi:10.1016/j.ijtb.2023.05.011 · Cited by 16 · see citing works

Cellular and Molecular Mechanisms of Repurposed Antidiabetic Drug as an Adjunctive Treatment for Tuberculosis

Gautam, R. K., Mishra, R., Sharma, K., & Sharma, M. (2021) · Springer eBooks · doi:10.1007/978-981-33-6827-9_15 · Cited by 2 · see citing works

Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis

Haugen, J. D., Ackart, D. F., Todd, A., DiLisio, J. E., Hoffman, S., Tanner, S., Kiran, D., Murray, M. B., Chicco, A. J., Obregón‐Henao, A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73212-y · Cited by 24 · see citing works