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Cited by 178Syphilis Diagnosis and TreatmentNeonatal and Maternal InfectionsHistorical Medical Research and Treatments

Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management

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De Santis, Marco, De Luca, Carmen, Mappa, Ilenia, Spagnuolo, Terryann, Licameli, Angelo, Straface, Gianluca, Scambia, Giovanni·2012·Infectious Diseases in Obstetrics and Gynecology
DOI 10.1155/2012/430585PMC PMC3398589
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Abstract

Congenital syphilis is still a cause of perinatal morbidity and mortality. Untreated maternal infection leads to adverse pregnancy outcomes, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death, and congenital disease among newborns. Clinical manifestations of congenital syphilis are influenced by gestational age, stage of maternal syphilis, maternal treatment, and immunological response of the fetus. It has been traditionally classified in early congenital syphilis and late congenital syphilis. Diagnosis of maternal infection is based on clinical findings, serological tests, and direct identification of treponemes in clinical specimens. Adequate treatment of maternal infection is effective for preventing maternal transmission to the fetus and for treating fetal infection. Prenatal diagnosis of congenital syphilis includes noninvasive and invasive diagnosis. Serological screening during pregnancy and during preconception period should be performed to reduce the incidence of congenital syphilis.

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Authors
De Santis, M., De Luca, C., Mappa, I., Spagnuolo, T., Licameli, A., Straface, G., & Scambia, G.
Affiliations
  • Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli”, Rome, Italy
  • Università Cattolica del Sacro Cuore (IT)
  • Policlinico Abano Terme (IT)
ORCID
Venue
Infectious Diseases in Obstetrics and Gynecology
Publisher
Hindawi Limited
Published
2012
Volume
2012
Pages
1-5
ISSN
  • 1064-7449 (ISSN-L)
  • 1098-0997
DOI
10.1155/2012/430585
PMC
PMC3398589
OpenAlex
W2007196328
Cited by
178
References
4
Citations by year
2026: 10 · 2025: 8 · 2024: 9 · 2023: 19 · 2022: 17 · 2021: 28 · 2020: 21 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 9 · 2012: 1
FWCI
6.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Infectious Diseases in Obstetrics and Gynecology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
Keywords
congenital syphilis, maternal syphilis, perinatal transmission, fetal death, stillbirth, preterm birth, low birth weight, neonatal death, early congenital syphilis, late congenital syphilis, prenatal diagnosis, serological screening, fetal therapy, perinatal morbidity
MeSH terms
Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Pregnancy, Pregnancy Complications, Infectious, Syphilis, Syphilis, Congenital, Infectious Disease Transmission, Vertical, Premature Birth, Perinatal Mortality

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