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Cited by 162Syphilis Diagnosis and TreatmentHistorical Medical Research and TreatmentsReproductive tract infections research

Treatment of syphilis in pregnancy and prevention of congenital syphilis.

Wendel Jr., George D., Sheffield, Jeanne S., Hollier, Lisa M., Hill, James B., Ramsey, Patrick S., Sánchez, Pablo J.·2002·Clinical Infectious Diseases
DOI 10.1086/342108
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Abstract

Studies about the management of syphilis during pregnancy were reviewed. They lacked uniformity in diagnostic criteria and study design. Currently recommended doses of benzathine penicillin G are effective in preventing congenital syphilis in most settings, although studies are needed regarding increased dosing regimens. Azithromycin and ceftriaxone offer potential alternatives for penicillin-allergic women, but insufficient data on efficacy limit their use in pregnancy. Ultrasonography provides a noninvasive means to examine pregnant women for signs of fetal syphilis, and abnormal findings indicate a risk for obstetric complications and fetal treatment failure. Ultrasonography should precede antepartum treatment during the latter half of pregnancy to gauge severity of fetal infection. However, optimal management of the affected fetus has not been established; collaborative management with a specialist is recommended. Antepartum screening remains a critical component of congenital syphilis prevention, even in the era of syphilis elimination.

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Crossref · 10.1086/342108

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  • Certain evidence indicates that additional therapy is beneficial for pregnant women to prevent congenital syphilis; for women who have primary, secondary, or early latent syphilis, a second dose of benzathine penicillin G 2.4 million units IM can be administered 1 week after the initial dose.

    “Certain evidence indicates that additional therapy is beneficial for pregnant women to prevent congenital syphilis. For women who have primary, secondary, or early latent syphilis, a second dose of benzathine penicillin G 2.4 million units IM can be administered 1 week after the initial dose (641–643).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [641]

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Authors
Wendel Jr., G. D., Sheffield, J. S., Hollier, L. M., Hill, J. B., Ramsey, P. S., & Sánchez, P. J.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • The University of Texas Health Science Center at Houston (US)
  • University of Alabama at Birmingham (US)
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2002-10-15
Volume
35
Issue
s2
Pages
S200-S209
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/342108
OpenAlex
W2151564143
Cited by
162
References
54
Citations by year
2026: 2 · 2025: 6 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 6 · 2012: 11
FWCI
1.60
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
maternal syphilis, congenital syphilis, benzathine penicillin G, azithromycin, ceftriaxone, penicillin allergy, ultrasonography, prenatal screening, pregnancy complications, syphilis elimination
MeSH terms
Female, Fetal Death, Fetal Distress, Humans, Obstetric Labor, Premature, Penicillin G Benzathine, Pregnancy, Serologic Tests, Syphilis, Syphilis, Congenital, Ultrasonography, HIV Infections, Practice Guidelines as Topic

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