The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Inflammation as a Link between Obesity and Metabolic Syndrome
Open accessAbstract
The metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome. The aim of this paper is to highlight the central role of obesity in the development of a chronic low-grade inflammatory state that leads to insulin resistance, endothelial and microvascular dysfunctions. It is thought that the starting signal of this inflammation is overfeeding and the pathway origins in all the metabolic cells; the subsequent increase in cytokine production recruits immune cells in the extracellular environment inducing an overall systemic inflammation. This paper focuses on the molecular and cellular inflammatory mechanisms studied until now.
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Cites
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Self-citationAdipokines: inflammation and the pleiotropic role of white adipose tissue
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Cited by
Microbial Changes during Pregnancy, Birth, and Infancy
Nuriel-Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 620
Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation
Rodríguez-Hernández, H., Simental-Mendía, L. E., Rodríguez-Ramírez, G., & Reyes-Romero, M. A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/678159 · Cited by 481
T cell-mediated regulation of the microbiota protects against obesity
Petersen, C., Bell, R., Klag, K. A., Lee, S.-H., Soto, R., Ghazaryan, A., Buhrke, K., Ekiz, H. A., Ost, K. S., Boudina, S., et al. (2019) · Science · doi:10.1126/science.aat9351 · Cited by 385
Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Setayesh, T., Nersesyan, A., Mišík, M., Ferk, F., Langie, S., Andrade, V. M., Haslberger, A., & Knasmüller, S. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.07.001 · Cited by 98
Metadata
- Authors
- Emanuela, F., Grazia, M., Marco, D. R., Maria Paola, L., Giorgio, F., & Marco, B.
- Venue
- Journal of Nutrition and Metabolism
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-7
- ISSN
- 2090-0724 (ISSN-L)
- 2090-0732
- OpenAlex
- W2027839715
- Cited by
- 357
- References
- 23
- FWCI
- 24.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- Emanuela, F., Grazia, M., Marco, D. R., Maria Paola, L., Giorgio, F., & Marco, B. (2012). Inflammation as a Link between Obesity and Metabolic Syndrome. Journal of Nutrition and Metabolism. https://doi.org/10.1155/2012/476380
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
