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Cited by 301Probiotics and Fermented FoodsGut microbiota and healthFatty Acid Research and Health

Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

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Rajkumar, Hemalatha, Mahmood, Naseha, Kumar, Manoj, Varikuti, Sudarshan Reddy, Challa, Hanumanth Reddy, Myakala, Shiva Prakash·2014·Mediators of Inflammation
DOI 10.1155/2014/348959PMC PMC3984795
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Abstract

To evaluate the effects of probiotic (VSL#3) and omega-3 fatty acid on insulin sensitivity, blood lipids, and inflammation, we conducted a clinical trial in 60 overweight (BMI>25), healthy adults, aged 40–60 years. After initial screening the subjects were randomized into four groups with 15 per group. The four groups received, respectively, placebo, omega-3 fatty acid, probiotic VSL#3, or both omega-3 and probiotic, for 6 weeks. Blood and fecal samples were collected at baseline and after 6 weeks. The probiotic (VSL#3) supplemented group had significant reduction in total cholesterol, triglyceride, LDL, and VLDL and had increased HDL (P<0.05) value. VSL#3 improved insulin sensitivity (P<0.01), decreased hsCRP, and favorably affected the composition of gut microbiota. Omega-3 had significant effect on insulin sensitivity and hsCRP but had no effect on gut microbiota. Addition of omega-3 fatty acid with VSL#3 had more pronounced effect on HDL, insulin sensitivity and hsCRP. Subjects with low HDL, insulin resistance, and high hsCRP had significantly lower total lactobacilli and bifidobacteria count and higher E. coli and bacteroides count.

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Cited by

Sorted by citations

Authors
Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P.
Affiliations
Indian Council of Medical Research (IN)
Corresponding author
Kumar, Manoj
ORCID
Venue
Mediators of Inflammation
Publisher
Hindawi Limited
Published
2014
Volume
2014
Pages
1-8
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
DOI
10.1155/2014/348959
PMC
PMC3984795
OpenAlex
W1995373964
Cited by
301
References
3
Citations by year
2026: 13 · 2025: 21 · 2024: 33 · 2023: 25 · 2022: 26 · 2021: 39 · 2020: 31 · 2019: 30 · 2018: 28 · 2017: 23 · 2016: 15 · 2015: 13 · 2014: 4
FWCI
26.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Nutrition, Hyderabad, India
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
omega-3 fatty acids, overweight adults, lipid profile, insulin sensitivity, insulin resistance, inflammatory markers, C-reactive protein, gut microbiota, HDL cholesterol, LDL cholesterol, triglycerides, lactobacilli, Bifidobacterium, Escherichia coli, Bacteroides
MeSH terms
Adult, Cholesterol, Female, Humans, Inflammation, Insulin Resistance, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Triglycerides, Fatty Acids, Omega-3, Probiotics, Gastrointestinal Tract, Overweight

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