T cell-mediated regulation of the microbiota protects against obesity
Open accessAbstract
T cells help keep you lean The gut microbiota is a critical factor regulating mammalian metabolism. The host immune system, in turn, can shape the microbiome, in part via immunoglobulin A (IgA) antibodies. Petersen et al. report that mice defective in T follicular helper cell development and gut IgA production show hallmarks of metabolic syndrome with age (see the Perspective by Wang and Hooper). These mice gain more weight, accumulate more fat, and show greater insulin resistance compared with controls. IgA in these mice inappropriately targets Clostridia species and allows for the outgrowth of Desulfovibrio. Clostridia suppress and Desulfovibrio enhance host lipid absorption by modulating CD36 expression. A better understanding of the microbial products that modulate lipid absorption may open the door to future therapies for obesity and metabolic disease. Science , this issue p. eaat9351 ; see also p. 316
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Deletion of T cell-dependent immunoglobulin A production enhances obesity, while reducing the abundance and diversity of Clostridium.
“Deletion of T cell-dependent immunoglobulin A production enhances obesity, while reducing the abundance and diversity of Clostridium [75].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [75]
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- Authors
- Petersen, C., Bell, R., Klag, K. A., Lee, S.-H., Soto, R., Ghazaryan, A., Buhrke, K., Ekiz, H. A., Ost, K. S., Boudina, S., O’Connell, R. M., Cox, J. E., Villanueva, C. J., Stephens, W. Z., & Round, J. L.
- Affiliations
- University of Utah (US)
- Corresponding author
- Stephens, W. Zac
- Round, June L.
- ORCID
- Venue
- Science
- Published
- 2019-07-26
- Volume
- 365
- Issue
- 6451
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7294966
- OpenAlex
- W2963132797
- Cited by
- 385
- References
- 45
- Citations by year
- 2026: 29 · 2025: 53 · 2024: 67 · 2023: 55 · 2022: 69 · 2021: 53 · 2020: 51 · 2019: 8
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (1253278)
- Wellcome Trust
- National Institutes of Health (n01ai095375-008, P40OD010995)
- National Institute on Aging (R01AG047956)
- National Heart, Lung, and Blood Institute (R00HL102228)
- National Institute of General Medical Sciences (R01GM114817, T32GM007464, DP2GM111099)
- National Institute of Allergy and Infectious Diseases (K22AI095375, N01 AI095375, R56AI107090, T32AI055434)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK091317)
- National Center for Complementary and Integrative Health (DP2AT008746)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- T cells, gut microbiota, obesity, immunoglobulin A, T follicular helper cells, metabolic syndrome, insulin resistance, Clostridia, Desulfovibrio, CD36, fat absorption, host-microbe interactions
- MeSH terms
- Host Microbial Interactions, Animals, Antibiosis, Clostridium, Desulfovibrio, Intestinal Absorption, Mice, Mutant Strains, Obesity, Metabolic Syndrome, Lipid Metabolism, T-Lymphocytes, Regulatory, Mice, Myeloid Differentiation Factor 88, Microbiota
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