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Cited by 299Cardiovascular and exercise physiologyMuscle metabolism and nutritionSports Performance and Training

Strength training increases resting metabolic rate and norepinephrine levels in healthy 50- to 65-yr-old men

Pratley, R., Nicklas, B., Rubin, M., Miller, J., Smith, A., Smith, M., Hurley, B., Goldberg, A.·1994·Journal of Applied Physiology
DOI 10.1152/jappl.1994.76.1.133
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Abstract

Resting metabolic rate (RMR) decreases with age, largely because of an age-related decline in fat-free mass (FFM). We hypothesized that a strength-training program capable of eliciting increases in FFM would also increase RMR in older individuals. To test this hypothesis, RMR, body composition, and plasma concentrations of certain hormones known to affect RMR were measured before and after a 16-wk heavy-resistance strength-training program in 13 healthy men 50–65 yr of age. Average strength levels, assessed by the three-repetition maximum test, increased 40% with training (P < 0.001). Body weight did not change, but body fat decreased (25.6 +/- 1.5 vs. 23.7 +/- 1.7%; P < 0.001) and FFM increased (60.6 +/- 2.2 vs. 62.2 +/- 2.1 kg; P < 0.01). RMR, measured by indirect calorimetry, increased 7.7% with strength training (6,449 +/- 217 vs. 6,998 +/- 226 kJ/24 h; P < 0.01). This increase remained significant even when RMR was expressed per kilogram of FFM. Strength training increased arterialized plasma norepinephrine levels 36% (1.1 +/- 0.1 vs. 1.5 +/- 0.1 nmol/l; P < 0.01) but did not change fasting glucose, insulin, or thyroid hormone levels. These results indicate that a heavy-resistance strength-training program increases RMR in healthy older men, perhaps by increasing FFM and sympathetic nervous system activity.

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Authors
Pratley, R., Nicklas, B., Rubin, M., Miller, J., Smith, A., Smith, M., Hurley, B., & Goldberg, A.
Affiliations
University of Maryland, Baltimore (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1994-01-01
Volume
76
Issue
1
Pages
133-137
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1994.76.1.133
OpenAlex
W2120739693
Cited by
299
References
0
Citations by year
2025: 5 · 2024: 8 · 2023: 6 · 2022: 14 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 13 · 2012: 14
FWCI
10.83
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08ag000494-03, 5r01ag007660-06, 5p01ag004402-10)
  • National Institute on Aging (P01-AG-04402, KO8-AG-00494, R01-AG-07660)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
resistance training, resting metabolic rate, norepinephrine, fat-free mass, aging, older men, body composition, sympathetic activity, age-related metabolic decline, fat mass
MeSH terms
Aged, Blood Glucose, Body Composition, Body Weight, Diet, Hormones, Humans, Male, Metabolism, Middle Aged, Norepinephrine, Oxygen Consumption, Physical Education and Training

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