Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis
Open accessAbstract
Objectives. To assess the efficacy and safety of berberine in the treatment of type 2 diabetes mellitus (T2DM). Methods. Randomized trials of berberine compared with lifestyle modification, placebo, and/or oral hypoglycaemics intervention on treating T2DM were included. Study population characteristics and outcome results were extracted independently by two reviewers. Meta-analyses were performed for data available. Results. Fourteen randomized trials, involving 1068 participants, were included in this study. Methodological quality was generally low. Compared with lifestyle modification with or without placebo, the cointervention of berberine and lifestyle modification showed significantly hypoglycaemic and antidyslipidemic response. Compared with oral hypoglycaemics including metformin, glipizide, or rosiglitazone, berberine did not demonstrate a significantly better glycaemic control but showed a mild antidyslipidemic effect. Compared with oral hypoglycaemic drugs, cointerventions with berberine and the same oral hypoglycaemics showed a better glycaemic control. No serious adverse effects from berberine were reported. Conclusions. Berberine appeared to be efficacious for treating hyperglycaemia and dyslipidemia in T2DM. However, the evidence of berberine for treating T2DM should be carefully interpreted due to the low methodological quality, small sample size, limited number of trials, and unidentified risks of bias.
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Meta-analyses of randomized trials confirm significant reductions in glycated hemoglobin, fasting glucose and lipid profile with berberine.
“Meta-analyses of randomized trials confirm significant reductions in glycated hemoglobin, fasting glucose and lipid profile with berberine [25,26,27,28]”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [25]
The Results (section 3.5) report significant reductions in fasting glucose and HbA1c, alongside improvements in several lipid measures, in pooled trials of berberine plus lifestyle modification. But lipid results varied by comparator: adding berberine to oral hypoglycaemics did not significantly improve triglycerides, LDL-C or HDL-C, and the Conclusion says its anti-dyslipidemic effect needs further confirmation. The claim overstates how consistently the meta-analysis supports reductions across the lipid profile. (LLM, conf=0.86)
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- Authors
- Dong, H., Wang, N., Zhao, L., & Lu, F.
- Affiliations
- Tongji Hospital (CN)
- Corresponding author
- Dong, Hui
- Lu, Fuer
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-12
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3478874
- OpenAlex
- W2012565726
- Cited by
- 225
- References
- 28
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 7 · 2023: 26 · 2022: 19 · 2021: 22 · 2020: 20 · 2019: 18 · 2018: 17 · 2017: 13 · 2016: 17 · 2015: 19 · 2014: 14 · 2013: 13 · 2012: 1
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (30801492)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- berberine, type 2 diabetes, glycemic control, hypoglycemic effect, dyslipidemia, lifestyle modification, oral antidiabetic drugs, metformin, glipizide, rosiglitazone, adverse effects, herbal medicine
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