Research progress on berberine with a special focus on its oral bioavailability

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

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Regulation of the mevalonate pathway

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

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An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391 · see citing works

Drug Metabolism and Variability among Patients in Drug Response

Wilkinson, G. R. (2005) · New England Journal of Medicine · doi:10.1056/nejmra032424 · Cited by 1,185 · see citing works

Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors

Rendić, S., & Carlo, F. J. D. (1997) · Drug Metabolism Reviews · doi:10.3109/03602539709037591 · Cited by 1,165 · see citing works

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

Cabreiro, F., Au, C., Leung, K.-Y., Vergara-Irigaray, N., Cochemé, H. M., Noori, T., Weinkove, D., Schuster, E., Greene, N. D. E., & Gems, D. (2013) · Cell · doi:10.1016/j.cell.2013.02.035 · Cited by 967 · see citing works

Efficacy of berberine in patients with type 2 diabetes mellitus

Yin, J., Xing, H., & Ye, J. (2008) · Metabolism · doi:10.1016/j.metabol.2008.01.013 · Cited by 801 · see citing works

Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)

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Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

Zhang, X., Zhao, Y., Xu, J., Xue, Z., Zhang, M., Pang, X., Zhang, X., & Zhao, L. (2015) · Scientific Reports · doi:10.1038/srep14405 · Cited by 630 · see citing works

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

Zhang, X., Zhao, Y., Zhang, M., Pang, X., Xu, J., Kang, C., Li, M., Zhang, C., Zhang, Z., Zhang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042529 · Cited by 615 · see citing works

Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers

Rege, B. D., Kao, J. P. Y., & Polli, J. E. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00055-6 · Cited by 510 · see citing works

A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities

Zhang, J., Guo, Z., Xue, Z., Sun, Z., Zhang, M., Wang, L., Wang, G., Wang, F., Xu, J., Cao, H., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.11 · Cited by 458 · see citing works

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Zhang, H., Wei, J., Xue, R., Wu, J.-D., Zhao, W., Wang, Z., Wang, S., Zhou, Z.-X., Song, D., Wang, Y., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.029 · Cited by 442 · see citing works

Berberine activates thermogenesis in white and brown adipose tissue

Zhang, Z., Zhang, H., Li, B., Meng, X.-J., Wang, J., Zhang, Y., Yao, S., Ma, Q., Jin, L., Yang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6493 · Cited by 439 · see citing works

Comparison Between Permeability Coefficients in Rat and Human Jejunum

Fagerholm, U., Johansson, M., & Lennernäs, H. (1996) · Pharmaceutical Research · doi:10.1023/a:1016065715308 · Cited by 438 · see citing works

Inhibition of P-Glycoprotein by D-α-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)

Dintaman, J. M., & Silverman, J. A. (1999) · Pharmaceutical Research · doi:10.1023/a:1015000503629 · Cited by 427 · see citing works

Lipid – An emerging platform for oral delivery of drugs with poor bioavailability

Chakraborty, S., Shukla, D., Mishra, B., & Singh, S. K. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.06.001 · Cited by 412 · see citing works

Berberine improves glucose metabolism through induction of glycolysis

Yin, J., Gao, Z., Liu, D., Liu, Z., & Ye, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00211.2007 · Cited by 411 · see citing works

Herbal Modulation of P‐Glycoprotein

Zhou, S., Lim, L. Y., & Chowbay, B. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-120028427 · Cited by 375 · see citing works

Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

Chen, W., Miao, Y.-Q., Fan, D.-J., Yang, S.-S., Lin, X., Meng, L.-K., & Tang, X. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9632-z · Cited by 363 · see citing works

Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats

Liu, Y.-T., Hao, H.-P., Xie, H.-G., Lai, L., Wang, Q., Liu, C.-X., & Wang, G.-J. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.033936 · Cited by 356 · see citing works

Hepatocyte Nuclear Factor 1α Plays a Critical Role in PCSK9 Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

Li, H., Dong, B., Park, S. W., Lee, H.-S., Chen, W., & Liu, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.052407 · Cited by 349 · see citing works

Transforming berberine into its intestine-absorbable form by the gut microbiota

Feng, R., Shou, J.-W., Zhao, Z.-X., He, C.-Y., Ma, C., Huang, M., Fu, J., Tan, X.-S., Li, X.-Y., Wen, B.-Y., et al. (2015) · Scientific Reports · doi:10.1038/srep12155 · Cited by 307 · see citing works

Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo

Cornaire, G., Woodley, J. F., Hermann, P., Cloarec, A., Arellano, C., & Houin, G. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.03.001 · Cited by 307 · see citing works

Application of Chitin and Chitosan Derivatives in the Pharmaceutical Field

Katō, Y., Onishi, H., & Machida, Y. (2003) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201033489748 · Cited by 301 · see citing works

Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

Zuo, F., Nakamura, N., Akao, T., & Hattori, M. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011361 · Cited by 284 · see citing works

Chitosans as absorption enhancers of poorly absorbable drugs

Schipper, N. G. M., Vårum, K. M., Stenberg, P., Ocklind, G., Lennernäs, H., & Artursson, P. (1999) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(99)00032-9 · Cited by 278 · see citing works

Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

Tan, X.-S., Ma, J.-Y., Feng, R., Ma, C., Chen, W.-J., Sun, Y.-P., Fu, J., Huang, M., He, C.-Y., Shou, J.-W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077969 · Cited by 266 · see citing works

Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression

Kong, W., Zhang, H., Song, D., Xue, R., Zhao, W., Wei, J., Wang, Y., Shan, N., Zhou, Z., Yang, P., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.08.013 · Cited by 266 · see citing works

Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant

Müller, R. H., Rühl, D., Runge, S., Schulze‐Forster, K., & Mehnert, W. (1997) · Pharmaceutical Research · doi:10.1023/a:1012043315093 · Cited by 265 · see citing works

Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis

Xia, X., Yan, J., Shen, Y., Tang, K., Yin, J., Zhang, Y., Yang, D., Liang, H., Ye, J., & Weng, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016556 · Cited by 262 · see citing works

Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage Form for Oral Delivery

Battu, S. K., Repka, M. A., Maddineni, S., Chittiboyina, A. G., Avery, M. A., & Majumdar, S. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9520-y · Cited by 261 · see citing works

Berberine decreases PCSK9 expression in HepG2 cells

Cameron, J., Ranheim, T., Kulseth, M. A., Leren, T. P., & Berge, K. E. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.02.004 · Cited by 232 · see citing works

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic

Maher, S., Leonard, T. W., Jacobsen, J. B., & Brayden, D. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.006 · Cited by 227 · see citing works

Vitamin E-TPGS Increases Absorption Flux of an HIV Protease Inhibitor by Enhancing Its Solubility and Permeability1

Yu, L. X., Bridgers, A., Polli, J. W., Vickers, A. W., Long, S. T., Roy, A., Winnike, R., & Coffin, M. D. (1999) · Pharmaceutical Research · doi:10.1023/a:1018939006780 · Cited by 225 · see citing works

The involvement of P-glycoprotein in berberine absorption

Pan, G., Wang, G., Liu, X., Fawcett, J. P., & Xie, Y. (2002) · Pharmacology &amp; Toxicology · doi:10.1034/j.1600-0773.2002.t01-1-910403.x · Cited by 225 · see citing works

Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis

Dong, H., Wang, N., Zhao, L., & Lu, F. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/591654 · Cited by 225 · see citing works

Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular Route

Anderberg, E. K., Lindmark, T., & Artursson, P. (1993) · Pharmaceutical Research · doi:10.1023/a:1018909210879 · Cited by 221 · see citing works

Randomized Controlled Trial of Berberine Sulfate Therapy for Diarrhea Due to Enterotoxigenic Escherichia coli and Vibrio cholerae

Rabbani, G. H., Butler, T., Knight, J., Sanyal, S. C., & Alam, K. (1987) · The Journal of Infectious Diseases · doi:10.1093/infdis/155.5.979 · Cited by 215 · see citing works

Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel

Malingré, M. M., Richel, D. J., Beijnen, J. H., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.4.1160 · Cited by 199 · see citing works

Determination of berberine in human plasma by liquid chromatography–electrospray ionization–mass spectrometry

Hua, W., Ding, L., Chen, Y., Gong, B., He, J., & Xu, G. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.03.022 · Cited by 192 · see citing works

The biology of Gram-positive sortase enzymes

Paterson, G. K., & Mitchell, T. J. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2003.12.007 · Cited by 185 · see citing works

The Role of Surfactants in the Reversal of Active Transport Mediated by Multidrug Resistance Proteins

Bogman, K., Erne-Brand, F., Alsenz, J., & Drewe, J. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10395 · Cited by 184 · see citing works

Stimulation of AMP-Activated Protein Kinase (AMPK) Is Associated with Enhancement of Glut1-Mediated Glucose Transport

Abbud, W., Habinowski, S. A., Zhang, J.-Z., Kendrew, J., Elkairi, F. S., Kemp, B. E., Witters, L. A., & Ismail‐Beigi, F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1935 · Cited by 184 · see citing works

Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and Obesity in High-Fat Diet-Fed C57BL/6J Mice

Xie, W., Gu, D., Li, J., Cui, K., & Zhang, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024520 · Cited by 183 · see citing works

Extracellular Signal-Regulated Kinase–Dependent Stabilization of Hepatic Low-Density Lipoprotein Receptor mRNA by Herbal Medicine Berberine

Abidi, P., Zhou, Y., Jiang, J., & Liu, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000181761.16341.2b · Cited by 176 · see citing works

Antimicrobial activity of berberine—a constituent ofMahonia aquifolium

Čerňáková, M., & Košťálová, D. (2002) · Folia Microbiologica · doi:10.1007/bf02818693 · Cited by 174 · see citing works

Intestinal Absorption Enhancement Via the Paracellular Route by Fatty Acids, Chitosans and Others: A Target for Drug Delivery

Cano-Cebrián, M. J., Zornoza, T., Granero, L. M., et al. (2005) · Current Drug Delivery · doi:10.2174/1567201052772834 · Cited by 171 · see citing works

Berberine and its metabolites: Relationship between physicochemical properties and plasma levels after administration to human subjects

Spinozzi, S., Colliva, C., Camborata, C., Roberti, M., Ianni, C., Neri, F., Calvarese, C., Lisotti, A., Mazzella, G., & Roda, A. (2014) · Journal of Natural Products · doi:10.1021/np400607k · Cited by 161 · see citing works

HEPATOBILIARY EXCRETION OF BERBERINE

Tsai, P.-L., & Tsai, T. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.4.405 · Cited by 160 · see citing works

Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation

Bansal, T., Akhtar, N., Jaggi, M., Khar, R. K., & Talegaonkar, S. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.07.010 · Cited by 157 · see citing works

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

Xue, M., Yang, M.-X., Zhang, W., Li, X.-M., Gao, D., Ou, Z., Li, Z., Li, X., Liu, S.-H., & Yang, S. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s51262 · Cited by 154 · see citing works

Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9

Ho, Y.-T., Yang, J., Li, T., Lin, J., Lin, J., Lai, K., Ma, C.-Y., Wood, W. G., & Chung, J. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.01.033 · Cited by 150 · see citing works

Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance

Fu, L., Liang, Y.-J., Deng, L., Ding, Y. P., Chen, L., Ye, Y.-L., Yang, X., & Pan, Q. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0742-5 · Cited by 145 · see citing works

Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats

Bansal, T., Mishra, G., Jaggi, M., Khar, R. K., & Talegaonkar, S. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.12.005 · Cited by 140 · see citing works

Berberine Activates GLUT1-Mediated Glucose Uptake in 3T3-L1 Adipocytes

Kim, S. H., Shin, E.-J., Kim, E.-D., Bayaraa, T., Frost, S. C., & Hyun, C. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.2120 · Cited by 136 · see citing works

Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla

Freile, M. L., Giannini, F., Pucci, G. N., et al. (2003) · Fitoterapia · doi:10.1016/s0367-326x(03)00156-4 · Cited by 136 · see citing works

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.

Bardelmeijer, H. A., Ouwehand, M., Buckle, T., et al. (2002) · PubMed · Cited by 135 · see citing works

Solid dispersion of berberine–phospholipid complex/TPGS 1000/SiO2: preparation, characterization and in vivo studies

Zhang, Z., Chen, Y., Deng, J. G., Jia, X., Zhou, J., & Lv, H. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.01.023 · Cited by 135 · see citing works

Cardiovascular effects of berberine in patients with severe congestive heart failure

Marin ‐ NETO, J. A., Maciel, B. C., Secches, A. L., & Gallo, L. (1988) · Clinical Cardiology · doi:10.1002/clc.4960110411 · Cited by 128 · see citing works

A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea‐Predominant Irritable Bowel Syndrome

Chen, C., Tao, C., Liu, Z., Lü, M., Pan, Q., Zheng, L., Li, Q., Song, Z., & Fichna, J. (2015) · Phytotherapy Research · doi:10.1002/ptr.5475 · Cited by 127 · see citing works

Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism

Zhang, Q., Xiao, X., Feng, K., Wang, T., Li, W., Yuan, T., Sun, X., Sun, Q., Xiang, H., & Wang, H. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/924851 · Cited by 124 · see citing works

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

Wang, L., Liu, L., Shi, Y., Cao, H., Chaturvedi, R., Calcutt, M. W., Hu, T., Ren, X., Wilson, K. T., Polk, D. B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036418 · Cited by 123 · see citing works

The effects of pharmaceutical excipients on drug disposition

Buggins, T. R., Dickinson, P. A., & Taylor, G. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.017 · Cited by 122 · see citing works

Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride

Zhu, J.-X., Tang, D., Feng, L., Zheng, Z., Wang, R.-S., Wu, A., Duan, T., He, B., & Quan, Z. (2012) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.683875 · Cited by 113 · see citing works

Berberine Inhibits Human Hepatoma Cell Invasion without Cytotoxicity in Healthy Hepatocytes

Liu, B., Wang, G., Yang, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021416 · Cited by 113 · see citing works

Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption

Wang, Y., Yi, X., Ghanam, K., Zhang, S., Zhao, T.-T., & Zhu, X. (2014) · Metabolism · doi:10.1016/j.metabol.2014.05.013 · Cited by 112 · see citing works

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes

Li, Y., Ren, G., Wang, Y.-X., Kong, W.-J., Yang, P., Wang, Y.-M., Li, Y.-H., Yi, H., Li, Z.-R., Song, D.-Q., et al. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-62 · Cited by 109 · see citing works

Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein

Zhang, X., Qiu, F., Jiang, J. C., Gao, C., & Tan, Y. (2011) · Xenobiotica · doi:10.3109/00498254.2010.529180 · Cited by 109 · see citing works

Excretion of Berberine and Its Metabolites in Oral Administration in Rats

Ma, J., Feng, R., Tan, X., Ma, C., Shou, J., Fu, J., Huang, M., He, C., Chen, S., Zhao, Z., et al. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23718 · Cited by 107 · see citing works

Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor

Chu, M., Ding, R., Chu, Z.-Y., Zhang, M., Liu, X.-Y., Xie, S.-H., Zhai, Y.-J., & Wang, Y. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-89 · Cited by 106 · see citing works

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

Jiang, S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7777 · Cited by 104 · see citing works

Binding Thermodynamics of Statins to HMG-CoA Reductase

Carbonell, T., & Freire, E. (2005) · Biochemistry · doi:10.1021/bi050905v · Cited by 102 · see citing works

Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats

Liu, Y., Hao, H., Xie, H., Lv, H., Liu, C., & Wang, G. (2009) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21721 · Cited by 101 · see citing works

Chemical Stability of Nucleic Acid–Derived Drugs

Pogocki, D., & Schöneich, C. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/(sici)1520-6017(200004)89:4 · Cited by 100 · see citing works

Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure−Activity Relationships, and Cholesterol-Lowering Efficacy

Li, Y., Yang, P., Kong, W., Wang, Y., Hu, C.-Q., Zuo, Z.-Y., Wang, Y., Gao, H., Gao, L., Feng, Y., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm801157z · Cited by 96 · see citing works

Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine

Wang, T., Wang, N., Song, H., Xi, X., Wang, J., Hao, A., & Li, T. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.06.015 · Cited by 96 · see citing works

Inhibition of the Bacterial Surface Protein Anchoring Transpeptidase Sortase by Isoquinoline Alkaloids

Kim, S.-H., Shin, D., Oh, M., Chung, S., Jang-Suk, L. E. E., & Oh, K. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.421 · Cited by 95 · see citing works

Determination of berberine in plasma, urine and bile by high-performance liquid chromatography

Chen, C., & Chang, H.-C. (1995) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(94)00517-9 · Cited by 92 · see citing works

Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements

Li, H., Chen, W., Zhou, Y., Abidi, P., Sharpe, O., Robinson, W. H., Kraemer, F. B., & Liu, J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800375-jlr200 · Cited by 92 · see citing works

Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells

Li, N., Gu, L., Qu, L., Gong, J., Li, Q., Zhu, W., & Li, J. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.02.001 · Cited by 89 · see citing works

Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control

Pierro, F. D., Villanova, Agostini, F., Soverini, V., Marchesini, G., & Marzocchi (2012) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s33718 · Cited by 87 · see citing works

Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability

Meng, Z., Zhang, M., Shengnan, W., Xiaojia, B., Hatch, G. M., Gu, J., & Li, C. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.03.017 · Cited by 86 · see citing works

CYP2D plays a major role in berberine metabolism in liver of mice and humans

Guo, Y., Li, F., Ma, X., Cheng, X., Zhou, H., & Klaassen, C. D. (2011) · Xenobiotica · doi:10.3109/00498254.2011.597456 · Cited by 86 · see citing works

Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis

Zhang, M., Lv, X., Li, J., Meng, Z., Wang, Q., Chang, W., Li, W., Chen, L., & Liu, Y. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.08.006 · Cited by 84 · see citing works

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

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Efficacy of Berberine, an Antimicrobial Plant Alkaloid, as an Endodontic Irrigant against a Mixed-culture Biofilm in an In Vitro Tooth Model

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