The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
Open accessAbstract
Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins. Proteins that are damaged beyond repair are degraded either by the proteasome or by the lysosome via autophagy. The aggregates can be degraded by the proteasome and by chaperone-mediated autophagy only after dissolution into soluble single peptide species. Hence, protein aggregates as such are degraded by macroautophagy. The selective degradation of protein aggregates by macroautophagy is called aggrephagy. Here we review the processes of aggregate formation, recognition, transport, and sequestration into autophagosomes by autophagy receptors and the role of aggrephagy in different protein aggregation diseases.
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Citations
Cites
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Protein folding and misfolding
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“We noted that p62 is a major protein in these structures and realized that ALIS and p62 bodies are indistinguishable structures [31].”
BackgroundInfluentialSelf-citationParkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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Aggresomes: A Cellular Response to Misfolded Proteins
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Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
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Background
Cited by
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
The autophagosome: origins unknown, biogenesis complex
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The mechanisms and roles of selective autophagy in mammals
Vargas, J. N. S., Hamasaki, M., Kawabata, T., Youle, R. J., & Yoshimori, T. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00542-2 · Cited by 1,016
Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899
The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.02.002 · Cited by 436
Metadata
- Authors
- Lamark, T., & Johansen, T.
- Venue
- International Journal of Cell Biology
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-21
- ISSN
- 1687-8876 (ISSN-L)
- 1687-8884
- OpenAlex
- W1990619980
- Cited by
- 497
- References
- 59
- FWCI
- 24.77
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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