The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
Open accessAbstract
The autophagy-lysosomal pathway (ALP) is involved in the degradation of long-lived proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein species, and accumulation of dysfunctional organelles, which are hallmarks of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and prion disease. Decades of research have therefore focused on enhancing the ALP in neurodegenerative diseases. More recently, transcription factor EB (TFEB), a major regulator of autophagy and lysosomal biogenesis, has emerged as a leading factor in addressing disease pathology. We review the regulation of the ALP and TFEB and their impact on neurodegenerative diseases. We also offer our perspective on the complex role of autophagy and TFEB in disease pathogenesis and its therapeutic implications through the examination of prion disease.
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TFE3 or TFEB upregulation or activation through pharmacological inhibition of mTORC1 can trigger clearance of excess α-synuclein and halt the progression of neurotoxicity.
“TFE3 or TFEB upregulation or activation through pharmacological inhibition of mTORC1 can trigger clearance of excess α-synuclein and halt the progression of neurotoxicity17–22.”
From PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease (2024) · cites this paper as [20]
The Parkinson’s Disease section reports that TFEB overexpression or activation ameliorates α-synuclein pathology, and that rapamycin inhibits mTOR and reduces that pathology in vitro and in vivo. It does not establish the same effect for TFE3 or show that these interventions halt the progression of neurotoxicity. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMolecular and histopathologic analyses of patient tissues demonstrate mislocalized or accumulated autophagy machinery, pathogenic mutations underlying familial neurodegenerative diseases disable known autophagy-related factors, and genetically ablating autophagy effectors produces neurodegeneration in cell and animal model systems, supporting a role for autophagy dysfunction in age-related neurode
“Molecular and histopathologic analyses of patient tissues demonstrate mislocalized or accumulated autophagy machinery, pathogenic mutations underlying familial neurodegenerative diseases disable known autophagy-related factors, and genetically ablating autophagy effectors produce neurodegeneration in cell and animal model systems [74–81], supporting a role for autophagy dysfunction in the devel”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [79]
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Self-citationStimulation of ATG12-ATG5 Conjugation by Ribonucleic Acid
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Lysosomes as dynamic regulators of cell and organismal homeostasis
Ballabio, A., & Bonifacino, J. S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0185-4 · Cited by 1,469 · see citing works
Self-citationTargeted protein degradation: mechanisms, strategies and application
Zhao, L., Zhao, J., Zhong, K., Tong, A., & Jia, D. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00966-4 · Cited by 986 · see citing works
Lysosomes as a therapeutic target
Bonam, S. R., Wang, F., & Muller, S. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0036-1 · Cited by 764 · see citing works
“TFEB has received particular attention in this regard [193] [194] [195] , with recent data suggesting that TFEB is selectively lost in patients with AD (as well as ALS) 196 .”
BackgroundAutophagy: The spotlight for cellular stress responses
Ravanan, P., Florance, I., & Talwar, P. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.029 · Cited by 578 · see citing works
Nixon, R. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700359 · Cited by 400 · see citing works
Role of lysosomes in physiological activities, diseases, and therapy
Zhang, Z., Yue, P., Lu, T., Wang, Y., Wei, Y., & Wei, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01087-1 · Cited by 364 · see citing works
“The autophagylysosome pathway (ALP) is essential for the survival of non-dividing neurons by contributing to the removal of abnormal large protein aggregates and organelles [76, 77].”
BackgroundSelective autophagy as a potential therapeutic target for neurodegenerative disorders
Scrivo, A., Bourdenx, M., Pampliega, O., & Cuervo, A. M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30238-2 · Cited by 355 · see citing works
AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3
Paquette, M., El–Houjeiri, L., Zirden, L. C., Puustinen, P., Blanchette, P., Jeong, H., Dejgaard, K., Siegel, P. M., & Pause, A. (2021) · Autophagy · doi:10.1080/15548627.2021.1898748 · Cited by 260 · see citing works
“Interestingly, TFEB and TFE3 also play important roles in non-dividing neurons to clear toxins and misfolded proteins through regulation of autophagic pathways [17].”
BackgroundAutophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases
Djajadikerta, A., Keshri, S., Tanasa, M. P., Prestil, R., Ryan, L., & Rubinsztein, D. C. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.035 · Cited by 238 · see citing works
“[141] Martini-Stoica H, Xu Y, Ballabio A, Zheng H.”
Wang, Y., Cheng, H., Wang, T., Zhang, K., Zhang, Y., & Kang, X. (2023) · Cell Proliferation · doi:10.1111/cpr.13448 · Cited by 239 · see citing works
“(TFEB) is the main transcription regulator of lysosome and autophagy genes.(168) Apigenin can promote the nuclear translocation of TFEB by”
BackgroundSTUB1 regulates TFEB‐induced autophagy–lysosome pathway
Sha, Y., Rao, L., Settembre, C., Ballabio, A., & Eissa, N. T. (2017) · The EMBO Journal · doi:10.15252/embj.201796699 · Cited by 231 · see citing works
“Methods to induce TFEB activation to enhance autophagy – lysosome-mediated degradation of misfolded proteins have been suggested for treatment of diseases associated with misfolded proteins such as neurodegenerative diseases (Decressac & Bjo¨rklund, 2013; Martini-Stoica et al , 2016).”
Self-citationZhang, W., Xu, C., Sun, J., Shen, H., Wang, J., & Yang, C. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.008 · Cited by 213 · see citing works
Autophagy in aging and longevity
Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2019) · Human Genetics · doi:10.1007/s00439-019-02031-7 · Cited by 204 · see citing works
Autophagy and ALS: mechanistic insights and therapeutic implications
Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works
Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
Seranova, E., Connolly, K. J., Zatyka, M., Rosenstock, T. R., Barrett, T. G., Tuxworth, R. I., & Sarkar, S. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170055 · Cited by 175 · see citing works
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The Lysosome Signaling Platform: Adapting With the Times
Inpanathan, S., & Botelho, R. J. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00113 · Cited by 157 · see citing works
The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders
Vidoni, C., Follo, C., Savino, M., Melone, M. A. B., & Isidoro, C. (2016) · Medicinal Research Reviews · doi:10.1002/med.21394 · Cited by 164 · see citing works
Autophagy in Bone Remodeling: A Regulator of Oxidative Stress
Zhu, C., Shen, S., Zhang, S., Huang, M., Zhang, L., & Chen, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.898634 · Cited by 166 · see citing works
Xu, Y., Propson, N. E., Du, S., Xiong, W., & Zheng, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023418118 · Cited by 171 · see citing works
Self-citationLysosomes in senescence and aging
Tan, J. X., & Finkel, T. (2023) · EMBO Reports · doi:10.15252/embr.202357265 · Cited by 160 · see citing works
Victoria, G. S., & Zurzolo, C. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201701047 · Cited by 150 · see citing works
“Lysosomal stress can also alter TFEB signaling, which is directly responsible for increasing lysosomal exocytosis (Martini-Stoica et al., 2016).”
BackgroundZhu, L., Yuan, Y., Yuan, L., Li, L., Liu, F., Liu, J., Chen, Y., Lu, Y., & Cheng, J. (2020) · Theranostics · doi:10.7150/thno.44051 · Cited by 153 · see citing works
“TFEB is a known master transcriptional regulator of autophagy and can regulate lysosome biogenesis and promote autophagosome-lysosome activity by binding to the CLEAR element on a variety of autophagy and lysosomal genes to induce their expression [41, 42].”
BackgroundIssa, A.-R., Sun, J., Petitgas, C., Mesquita, A., Dulac, A., Robin, M., Mollereau, B., Jenny, A., Chérif‐Zahar, B., & Birman, S. (2018) · Autophagy · doi:10.1080/15548627.2018.1491489 · Cited by 152 · see citing works
Chandra, S., Roy, A., Jana, M., & Pahan, K. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.12.007 · Cited by 149 · see citing works
Autophagy impairment in Parkinson’s disease
Karabiyik, C., Lee, M. J., & Rubinsztein, D. C. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170023 · Cited by 137 · see citing works
“Translocation of TFEB to the nucleus enables its transcriptional activity, autophagosome formation and autophagosome-lysosome fusion (16).”
BackgroundHoller, C. J., Taylor, G., Deng, Q., & Kukar, T. L. (2017) · eNeuro · doi:10.1523/eneuro.0100-17.2017 · Cited by 133 · see citing works
“Lysosome dysfunction is a common occurrence in numerous neurodegenerative diseases (Platt et al., 2012; Martini-Stoica et al., 2016) and growing evidence indicates a critical role for PGRN in the maintenance of lysosome homeostasis (Ahmed et al.”
BackgroundChandra, S., Jana, M., & Pahan, K. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0054-18.2018 · Cited by 134 · see citing works
“Lysosomal adaptation under different physiological and pathological scenarios is dependent on a regulatory gene network known as CLEAR (coordinated lysosomal expression and regulation), with the master regulator TFEB at its core (Sardiello et al., 2009; Martini-Stoica et al., 2016).”
BackgroundIyaswamy, A., Thakur, A., Guan, X.-J., Krishnamoorthi, S., Fung, T. Y., Lu, K., Gaurav, I., Yang, Z., Su, C.-F., Lau, K.-F., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01657-4 · Cited by 134 · see citing works
“28,29 Interestingly, a relationship between exosomes and autophagy that is considered a key protein degradation pathway functioning to clear misfolded proteins in various neurodegenerative diseases including AD, has been studied.”
BackgroundExercise activates lysosomal function in the brain through AMPK‐SIRT1‐TFEB pathway
Huang, J., Wang, X., Zhu, Y., Li, Z., Zhu, Y., Wu, J., Qin, Z., Xiang, M., & Lin, F. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13114 · Cited by 129 · see citing works
Xu, Y., Du, S., Marsh, J. A., Horie, K., Sato, C., Ballabio, A., Karch, C. M. M., Holtzman, D. M., & Zheng, H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0738-0 · Cited by 121 · see citing works
Self-citationPost-translational modifications: Regulators of neurodegenerative proteinopathies
Gupta, R. V., Sahu, M., Srivastava, D., Tiwari, S., Ambasta, R. K., & Kumar, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101336 · Cited by 124 · see citing works
Members, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology · doi:10.1007/s00204-017-2133-4 · Cited by 124 · see citing works
“The two main systems for the removal of misfolded proteins are: (1) the autophagy–lysosomal pathway (ALP), which removes dysfunctional proteins, aggregates, and even subcellular organelles; and (2) the ubiquitin proteasomal system (UPS), which catalyzes the tagging of target proteins by ubiquitination, followed by the…”
BackgroundRegulated cell death: discovery, features and implications for neurodegenerative diseases
Cui, J., Zhao, S., Li, Y., Zhang, D., Wang, B., Xie, J., & Wang, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00799-8 · Cited by 125 · see citing works
“Deficiencies in the autophagy-lysosomal pathway can contribute to the aggregation of abnormal protein, the generation of toxic substances and the accumulation of dysfunctional organelles [149].”
BackgroundZhang, Z., Yan, J., Bowman, A. B., Bryan, M. R., Singh, R., & Aschner, M. (2019) · Autophagy · doi:10.1080/15548627.2019.1688488 · Cited by 116 · see citing works
Roles of Autophagy-Related Genes in the Pathogenesis of Inflammatory Bowel Disease
Kim, S., Eun, H. S., & Jo, E. (2019) · Cells · doi:10.3390/cells8010077 · Cited by 120 · see citing works
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease
Liu, J., Liu, C., Zhang, J., Zhang, Y., Liu, K., Song, J., Sreenivasmurthy, S. G., Wang, Z., Shi, Y., Chu, C., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b06453 · Cited by 116 · see citing works
Gao, L., Li, X., Meng, S., Ma, T., Wan, L., & Xu, S. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s235969 · Cited by 115 · see citing works
Targeting Autophagy to Overcome Human Diseases
Condello, M., Pellegrini, E., Caraglia, M., & Meschini, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030725 · Cited by 113 · see citing works
“The EB transcription factor (TFEB) has been identified as the factor that positively regulates genes related to formation of autophagosomes and the lysosome fusion, increasing the clearance of lysosomal exocytosis [104].”
BackgroundYang, C., Su, C.-F., Iyaswamy, A., Krishnamoorthi, S. K., Zhu, Z., Yang, S., Tong, B. C., Liu, J., Sreenivasmurthy, S. G., Guan, X., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.017 · Cited by 112 · see citing works
Autophagy–lysosomal-associated neuronal death in neurodegenerative disease
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“The first step is the formation of a crescent-shaped double membrane (phagophore or isolation membrane) derived from multiple sources, such as cytoplasmic membrane, mitochondria, or ER- and Golgi apparatus [96,122].”
BackgroundTFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
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“Lysosomes play essential roles in cellular homeostasis through the LYNUS system and the coordinated mTOR-TFEB lysosome to nucleus signaling 24 .”
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Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies
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“The autophagy lysosomal pathway (ALP) likely plays a major role in PD pathogenesis,(4) as deficits in the ALP may lead to α-synuclein aggregation and accumulation and reduction in glucocerebrosidase (GCase) activity.(5) GCase is encoded by GBA, which harbors variants that are among the most common risk factors for PD.”
BackgroundAn FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
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“Our understanding of the link between autophagy and synaptic structure and function in absence of neurodegeneration (Menzies et al., 2015; Martini-Stoica et al., 2016) has been limited.”
BackgroundTFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux
Zheng, G., Pan, Z., Zhan, Y., Tang, Q., Zheng, F., Zhou, Y., Wu, Y., Zhou, Y., Chen, D., Chen, J., et al. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.10.011 · Cited by 97 · see citing works
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“Transcription factor EB (TFEB), which is a component of the microphthalmia transcription factor family, is considered a master modulator of autophagy activity and lysosome biogenesis [28].”
BackgroundKrohn, L., Heilbron, K., Blauwendraat, C., Reynolds, R. H., Yu, E., Senkevich, K. A., Rudakou, U., Estiar, M. A., Gustavsson, E. K., Brolin, K. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34732-5 · Cited by 101 · see citing works
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation
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Emerging pathways driving early synaptic pathology in Alzheimer's disease
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“Lysosome dysfunction is implicated along multiple lines of evidence in neurodegenerative disease - AD, Parkinson’s Disease and Huntington’s Disease in particular [13,32,48,65,72,93,119].”
BackgroundTherapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols
Ajami, M., Pazoki–Toroudi, H., Amani, H., Nabavi, S. F., Braidy, N., Vacca, R. A., Atanasov, A. G., MOCAN, A., & Nabavi, S. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.022 · Cited by 91 · see citing works
“ALP impairment esults in aggregation of toxic protein species, and accumulation f damaged organelles such as dysfunctional mitochondria that ead to development and progression of neurodegenerative disorers (Martini-Stoica et al., 2016).”
Enhancing autophagy in Alzheimer's disease through drug repositioning
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Recent advances in organelle-targeted organic photosensitizers for efficient photodynamic therapy
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Self-citationTranscription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
Arotçarena, M.-L., Bourdenx, M., Dutheil, N., Thiolat, M.-L., Doudnikoff, É., Doveró, S., Ballabio, A., Fernagut, P., Meissner, W. G., Bézard, E., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129719 · Cited by 82 · see citing works
“Since TFEB is a master gene in the regulation of ALP (17–20, 22), we Because alteration of lysosomal integrity, and lysosomal membrane permeabilization especially, have been described in synucleinopathies (38, 39), we next explored whether overexpression of TFEB could rescue lysosomal membrane…”
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“compound HP-β-CD was reported to modulate autophagy by increasing TFEB nuclear translocation in human neuroglioma cells.(29,35,36) Treatment with HPβ-CD during the entire differentiation process was able to increase the proportion of nuclei that colocalized with TFEB in a two-dimensional neuronal culture at 21 days of…”
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“Transcription factor EB (TFEB) is a recently discovered key regulator of autophagy-lysosome pathway to promote protein clearance.(25,41) TFEB could upregulate the expression of nearly two-thirds of autophagy-”
BackgroundTFEB is a master regulator of tumor-associated macrophages in breast cancer
Li, Y., Hodge, J., Liu, Q., Wang, J., Wang, Y., Evans, T. D., Altomare, D., Yao, Y., Murphy, E. A., Razani, B., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000543 · Cited by 81 · see citing works
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Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms
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TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
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“Cellular stress inactivates mTORC1, leading to dephosphorylation of TFEB, its release from 14-3-3 proteins and translocation of the transcription factor to the nucleus (Settembre et al., 2011; Martini-Stoica et al., 2016).”
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“The aberrant expression/activity of TFEB is evident in several pathological conditions, especially in age-related degenerative or lysosomal storage disorders, where TFEB impairment leads to accumulation of misfolded or damaged proteins in aggresome-bodies (34, 47).”
Grimm, C. M., Butz, E. S., Chen, C., Wahl‐Schott, C., & Biel, M. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.04.003 · Cited by 68 · see citing works
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BackgroundSelf-citationMitochondria–lysosome membrane contacts are defective in GDAP1-related Charcot–Marie–Tooth disease
Cantarero, L., Juárez‐Escoto, E., Civera-Tregón, A., Rodríguez-Sanz, M., Roldán, M., Benítez, R., Hoenicka, J., & Palau, F. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa243 · Cited by 67 · see citing works
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Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation
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The fluorescence toolbox for visualizing autophagy
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TFEB in Alzheimer's disease: From molecular mechanisms to therapeutic implications
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“Recently, studies have demonstrated the roles of TFEB and ALP dysfunction in the development of several neurodegenerative diseases, including AD (Boland et al., 2018; Martini-Stoica et al., 2016; Song et al., 2021).”
BackgroundNatural products for the treatment of neurodegenerative diseases
Cui, D., Chen, Y., Ye, B., Guo, W., Wang, D., & He, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155101 · Cited by 63 · see citing works
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“TFEB activity is regulated by mTORC1-mediated phosphorylation at specific serine residues in response to changes in nutritional status.(16)”
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“, 2016), Alzheimer’s disease (Martini-Stoica et al., 2016), amyotrophic lateral sclerosis (ALS) (Kiriyama and Nochi, 2015), hereditary spastic paraplegia (HSP) (Ebrahimi-Fakhari et al.”
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Melatonin as an endogenous regulator of diseases: The role of autophagy
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“Studies have demonstrated that TFEB promotes the expression of genes in the autophagy pathway, as well as genes encoding the components of lysosomes [29, 50, 51].”
BackgroundThe Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases
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“The activation and translocation of TFEB are sequentially initiated under exposure of cellular stress, such as starvation and lysosomal dysfunction (Martina et al., 2012; Roczniak-Ferguson et al., 2012; Medina et al., 2015).”
BackgroundInfluentialTranscription factor EB: an emerging drug target for neurodegenerative disorders
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“TFEB downregulation or deficiency can obviously affect the cellular phenotype in a physiologically relevant manner in settings including atherosclerosis [26], nonalcoholic fatty liver disease [27], cancer [28] and neurodegeneration [29].”
BackgroundMaterial properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway
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- Authors
- Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Zheng, Hui
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 39
- Issue
- 4
- Pages
- 221-234
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC4928589
- OpenAlex
- W2293027573
- Cited by
- 436
- References
- 127
- Citations by year
- 2026: 38 · 2025: 41 · 2024: 46 · 2023: 65 · 2022: 48 · 2021: 53 · 2020: 43 · 2019: 34 · 2018: 27 · 2017: 31 · 2016: 10
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (RF1AG020670, F30AG050412, R01AG020670)
- National Institute of Neurological Disorders and Stroke (R01NS076117, RF1NS093652, R01NS078072, R01NS093652)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- autophagy-lysosome pathway, TFEB, neurodegenerative diseases, lysosomal biogenesis, protein aggregation, Alzheimer's disease, Parkinson's disease, Huntington's disease, prion disease, autophagy regulation, therapeutic target
- MeSH terms
- Animals, Autophagy, Brain, Humans, Lysosomes, Nerve Degeneration, Neurodegenerative Diseases, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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