The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Challenges and Opportunities for Small Molecule Aptamer Development
Open accessAbstract
Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.
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Cites
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754
An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.
Mills, D. R., Peterson, R. L., & Spiegelman, S. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.1.217 · Cited by 648
Jolma, A., Kivioja, T., Toivonen, J., Cheng, L., Wei, G., Enge, M., Taipale, M., Vaquerizas, J. M., Yan, J., Sillanpää, M. J., et al. (2010) · Genome Research · doi:10.1101/gr.100552.109 · Cited by 441
In-Line Probing Analysis of Riboswitches
Regulski, E. E., & Breaker, R. R. (2008) · Methods In Molecular Biology™ · doi:10.1007/978-1-59745-033-1_4 · Cited by 338
Aptamer base: a collaborative knowledge base to describe aptamers and SELEX experiments
Cruz-Toledo, J., McKeague, M., Zhang, X., Giamberardino, A., McConnell, E., Francis, T., DeRosa, M. C., & Dumontier, M. (2012) · Database · doi:10.1093/database/bas006 · Cited by 95
Self-citationRuff, K. M., Snyder, T. M., & Liu, D. R. (2010) · Journal of the American Chemical Society · doi:10.1021/ja103023m · Cited by 86
Cited by
Bariya, M., Nyein, H. Y. Y., & Javey, A. (2018) · Nature Electronics · doi:10.1038/s41928-018-0043-y · Cited by 1,486
Metadata
- Authors
- McKeague, M., & DeRosa, M. C.
- Venue
- Journal of Nucleic Acids
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-20
- ISSN
- 2090-0201 (ISSN-L)
- 2090-021X
- OpenAlex
- W1978419983
- Cited by
- 466
- References
- 6
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- gold
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