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Global Fluoroquinolone Resistance Epidemiology and Implictions for Clinical Use

Open access
Dalhoff, Axel·2012·Interdisciplinary Perspectives on Infectious Diseases

Abstract

This paper on the fluoroquinolone resistance epidemiology stratifies the data according to the different prescription patterns by either primary or tertiary caregivers and by indication. Global surveillance studies demonstrate that fluoroquinolone resistance rates increased in the past years in almost all bacterial species except S. pneumoniae and H. influenzae, causing community-acquired respiratory tract infections. However, 10 to 30% of these isolates harbored first-step mutations conferring low level fluoroquinolone resistance. Fluoroquinolone resistance increased in Enterobacteriaceae causing community acquired or healthcare associated urinary tract infections and intraabdominal infections, exceeding 50% in some parts of the world, particularly in Asia. One to two-thirds of Enterobacteriaceae producing extended spectrum -lactamases were fluoroquinolone resistant too. Furthermore, fluoroquinolones select for methicillin resistance in Staphylococci.Neisseria gonorrhoeae acquired fluoroquinolone resistance rapidly; actual resistance rates are highly variable and can be as high as almost 100%, particularly in Asia, whereas resistance rates in Europe and North America range from <10% in rural areas to >30% in established sexual networks. In general, the continued increase in fluoroquinolone resistance affects patient management and necessitates changes in some guidelines, for example, treatment of urinary tract, intra-abdominal, skin and skin structure infections, and traveller’s diarrhea, or even precludes the use in indications like sexually transmitted diseases and enteric fever.

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Metadata

Authors
Dalhoff, A.
Venue
Interdisciplinary Perspectives on Infectious Diseases
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-37
ISSN
  • 1687-708X (ISSN-L)
  • 1687-7098
OpenAlex
W2046548856
Cited by
354
References
10
FWCI
7.04
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Global Fluoroquinolone Resistance Epidemiology and Implictions for Clinical Use. https://app.cochat.ai/papers/10.1155/2012/976273
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Dalhoff, A. (2012). Global Fluoroquinolone Resistance Epidemiology and Implictions for Clinical Use. Interdisciplinary Perspectives on Infectious Diseases. https://doi.org/10.1155/2012/976273

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.