Cited by 368Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and AdiposityLiver Disease Diagnosis and Treatment

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.

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Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., Jazet, I. M.·2012·International Journal of Endocrinology

Abstract

The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions.

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Crossref · 10.1155/2012/983814

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Research works printed but not linked: 8

  1. 1993, Annals of Internal Medicine, 119, 655
  2. 2003, Netherlands Journal of Medicine, 61, 194
  3. 2001, American Journal of Physiology, 280, E632
  4. 1984, International Journal of Obesity, 8, 97
  5. 2000, Annals of Internal Medicine, 132, 112
  6. 1990, International Journal of Obesity, 14, 1013
  7. 2008, Heart, 94
  8. 1947, La Presse Médicale, 55, 339

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Items 301–368 of 368

Metadata

Authors
Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., & Jazet, I. M.
Affiliations
  • Leiden University Medical Center (NL)
  • Department of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands
Corresponding author
Jazet, I. M.
Venue
International Journal of Endocrinology
Published
2012
Volume
2012
Pages
1-18
ISSN
  • 1687-8337 (ISSN-L)
  • 1687-8345
OpenAlex
W2025152562
Cited by
368
References
124
Citations by year
2026: 25 · 2025: 30 · 2024: 32 · 2023: 27 · 2022: 33 · 2021: 34 · 2020: 32 · 2019: 21 · 2018: 17 · 2017: 17 · 2016: 18 · 2015: 24 · 2014: 24 · 2013: 29 · 2012: 4
FWCI
20.79
Type
journal article
Language
en
Open access
Locations
  • International Journal of Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords
ectopic fat, insulin resistance, type 2 diabetes, hepatic steatosis, diet-induced weight loss, physical activity, lifestyle intervention

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