Allicin attenuates inflammation and suppresses HLA-B27 protein expression in ankylosing spondylitis mice
Open accessAbstract
Here we aimed to determine the therapeutic effect of allicin on ankylosing spondylitis (AS) and explore the mechanism(s) of action. AS mouse model was constructed by transferring the HLA-B2704 gene into Kunming mice and verified by RT-PCR and CT imaging. Verified AS mice were randomly divided into model group (n=6) and allicin-treated groups (50, 100, and 200 mg/kg, resp.,n=6, p.o., for 2 months). Wild type mice were used as control (n=6). The levels of AS-related inflammatory factors were measured by ELISA. mRNA and protein expressions of HLA-B27 were checked by RT-PCR and western blotting. As the results, the mouse model of AS was successfully established, and high-dose allicin could markedly alleviate spine inflammatory injury possibly via reducing the secretion of the inflammatory factors (IL-6, IL-8, and TNF-α) sharply in AS mice. Moreover, allicin significantly inhibited HLA-B27 protein translation but failed to suppress HLA-B27 gene transcription in AS mice, indicating a posttranscriptional mechanism of this modulation. In conclusion, allicin has potential to be used for AS treatment as an anti-inflammatory nutraceutical.
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The anti-inflammatory activity of garlic is caused by inhibiting the emigration of neutrophilic granulocytes into epithelia.
“Hobauer et al. [71], as well as Gu et al. [72], observed that the anti-inflammatory activity of garlic is caused by inhibiting the emigration of neutrophilic granulocytes into epithelia.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [72]
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
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- Authors
- Gu, X., Wu, H., & Fu, P.
- Affiliations
- Tongji University (CN)
- Second Military Medical University (CN)
- Corresponding author
- Wu, Haishan
- Venue
- BioMed Research International
- Publisher
- Hindawi Limited
- Published
- 2013
- Volume
- 2013
- Pages
- 1-6
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3845688
- OpenAlex
- W2158796538
- Cited by
- 49
- References
- 30
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 3
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Health Sciences › Medicine › Physiology › Sarcoidosis and Beryllium Toxicity Research
- Keywords
- allicin, ankylosing spondylitis, HLA-B27, inflammation, post-transcriptional regulation, interleukin-6, interleukin-8, TNF-α, nutraceuticals, anti-inflammatory therapy
- MeSH terms
- Animals, Disease Models, Animal, Disulfides, Humans, Inflammation, Mice, Transgenic, Spondylitis, Ankylosing, Sulfinic Acids, Tumor Necrosis Factor-alpha, HLA-B27 Antigen, Interleukin-6, Gene Expression Regulation, Neoplastic, Interleukin-8, Mice
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