Osteosarcoma: Evolution of Treatment Paradigms
Open accessAbstract
This paper reviews the contribution of chemotherapy in the conquest of osteosarcoma. It discusses how the treatment of osteosarcoma has evolved over the last five decades, resulting in a more than fivefold increase in survival. Though the initial improvements in survival were dramatic, essentially there has been no change in the outlook for this disease over the past 30 years. The paper also highlights the necessity of a multidisciplinary approach to combat this disease and stresses the need to explore newer treatment agents in order to build on the lessons learnt from the past while striving to achieve greater levels of success.
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Progress in osteosarcoma was made with the introduction of systemic chemotherapy, which was soon administered neoadjuvantly.
“Progress was only made with the introduction of systemic chemotherapy, which was soon administered neoadjuvantly 127 .”
From Osteosarcoma (2022) · cites this paper as [127]
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Sorted by citations
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
- Authors
- Jaffe, N., Puri, A., & Gelderblom, H.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Tata Memorial Hospital (IN)
- Leiden University Medical Center (NL)
- Corresponding author
- Jaffe, Norman
- Venue
- Sarcoma
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-7
- ISSN
- 1357-714X (ISSN-L)
- 1369-1643
- PMC
- PMC3678494
- OpenAlex
- W1986871224
- Cited by
- 93
- References
- 55
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 8 · 2015: 2 · 2014: 5 · 2013: 1
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Sarcoma (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- osteosarcoma, chemotherapy, treatment paradigm, survival, multidisciplinary treatment, novel therapeutic agents
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