Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk
Open accessAbstract
BACKGROUND: The authors summarized the outcomes of patients with unresectable osteosarcoma of the trunk who received carbon ion radiotherapy (CIRT). METHODS: The authors performed a retrospective analysis of 78 patients who had medically inoperable osteosarcoma of the trunk and received treatment with CIRT between 1996 and 2009. Tumor sites included the pelvis in 61 patients, the spine and paraspinal region in 15 patients, and other sites in 2 patients. The median applied CIRT dose was 70.4 Gray equivalent (GyE) in a total of 16 fixed fractions over 4 weeks. RESULTS: The minimum duration of follow‐up for survivors was 14 months. Forty‐eight patients remained alive. The 5‐year overall survival rate was 33%, and the local control rate was 62%. Thirty‐eight patients who had a clinical target volume <500 cm 3 had a 5‐year overall survival rate of 46% and a 5‐year local control rate of 88%. Except for 3 patients who experienced severe skin/soft tissue complications requiring skin grafts, no other severe toxicities were observed. Of 9 patients who were continuously disease free for >5 years, 8 were able to walk with or without the help of a cane, and 6 were free from pain killers. CONCLUSIONS: CIRT appeared to be a safe and effective modality for the management of unresectable osteosarcoma of the trunk, providing good local control and offering a survival advantage and good long‐term functional results without unacceptable morbidity. Cancer 2012. © 2012 American Cancer Society.
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Five-year local control rates of 62-67% in patients with inoperable pelvic and trunk sarcomas are encouraging.
“Five-year local control rates of 62-67% in patients with inoperable pelvic and trunk sarcomas are encouraging 138,139 .”
From Osteosarcoma (2022) · cites this paper as [139]
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- Authors
- Matsunobu, A., Imai, R., Kamada, T., Imaizumi, T., Tsuji, H., Tsujii, H., Shioyama, Y., Honda, H., Tatezaki, S., & for the Working Group for Bone and Soft Tissue Sarcomas
- Affiliations
- Kyushu University (JP)
- National Institute of Radiological Sciences (JP)
- Chiba Cancer Center (JP)
- Corresponding author
- Imai, Reiko
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2012-02-22
- Volume
- 118
- Issue
- 18
- Pages
- 4555-4563
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W1600280574
- Cited by
- 158
- References
- 34
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 16 · 2020: 17 · 2019: 15 · 2018: 8 · 2017: 12 · 2016: 8 · 2015: 11 · 2014: 5 · 2013: 9 · 2012: 3
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Keywords
- carbon ion radiotherapy, osteosarcoma, trunk, unresectable tumors, pelvis, spine, local control, overall survival, clinical target volume, treatment toxicity, functional outcome
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Bone Neoplasms, Child, Female, Humans, Male, Middle Aged, Retrospective Studies, Osteosarcoma, Treatment Outcome, Young Adult, Heavy Ion Radiotherapy
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