Mesenchymal Stem Cell-Like Cells Derived from Mouse Induced Pluripotent Stem Cells Ameliorate Diabetic Polyneuropathy in Mice
Open accessAbstract
Background. Although pathological involvements of diabetic polyneuropathy (DPN) have been reported, no dependable treatment of DPN has been achieved. Recent studies have shown that mesenchymal stem cells (MSCs) ameliorate DPN. Here we demonstrate a differentiation of induced pluripotent stem cells (iPSCs) into MSC-like cells and investigate the therapeutic potential of the MSC-like cell transplantation on DPN.Research Design and Methods. For induction into MSC-like cells, GFP-expressing iPSCs were cultured with retinoic acid, followed by adherent culture for 4 months. The MSC-like cells, characterized with flow cytometry and RT-PCR analyses, were transplanted into muscles of streptozotocin-diabetic mice. Three weeks after the transplantation, neurophysiological functions were evaluated.Results. The MSC-like cells expressed MSC markers and angiogenic/neurotrophic factors. The transplanted cells resided in hindlimb muscles and peripheral nerves, and some transplanted cells expressed S100 β in the nerves. Impairments of current perception thresholds, nerve conduction velocities, and plantar skin blood flow in the diabetic mice were ameliorated in limbs with the transplanted cells. The capillary number-to-muscle fiber ratios were increased in transplanted hindlimbs of diabetic mice.Conclusions. These results suggest that MSC-like cell transplantation might have therapeutic effects on DPN through secreting angiogenic/neurotrophic factors and differentiation to Schwann cell-like cells.
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iPSCs have been shown to ameliorate diabetic polyneuropathy in mice.
“In addition, iPSCs have been shown to ameliorate diabetic polyneuropathy (a neuropathic disorder associated with diabetes mellitus) in mice (156), and to activate an angiogenic response in mice with hindlimb ischemia (157).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [156]
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- Authors
- Himeno, T., Kamiya, H., Naruse, K., Cheng, Z., Ito, S., Kondo, M., Okawa, T., Fujiya, A., Kato, J., Suzuki, H., Kito, T., Hamada, Y., Oiso, Y., Isobe, K., & Nakamura, J.
- Affiliations
- Nagoya University (JP)
- Aichi Medical University (JP)
- Aichi Gakuin University (JP)
- Corresponding author
- Kamiya, Hideki
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-12
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3844199
- OpenAlex
- W2140229326
- Cited by
- 44
- References
- 42
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 5
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (25293166, 23591303)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- diabetic polyneuropathy, mesenchymal stem cells, induced pluripotent stem cells, cell transplantation, retinoic acid differentiation, angiogenic factors, neurotrophic factors, S100β, nerve conduction velocity, capillary density, streptozotocin-induced diabetes, peripheral nerve regeneration
- MeSH terms
- Animals, beta-Galactosidase, Blood Glucose, Body Weight, Capillaries, Cell Differentiation, Diabetic Neuropathies, Extremities, Male, Nerve Growth Factors, Neural Conduction, Perception, Peripheral Nerves, Regional Blood Flow, Skin, Biomarkers, Cellular Senescence, Muscle Fibers, Skeletal, Cyclin-Dependent Kinase Inhibitor p16, Angiogenesis Inducing Agents, Mesenchymal Stem Cell Transplantation, Green Fluorescent Proteins, Mice, Induced Pluripotent Stem Cells, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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