The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
Open accessAbstract
Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs. Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects. By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug. Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins. Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system. In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed. In particular, stealth nanocarriers can be obtained by polymeric coating. In this paper, the basic concept underlining the “stealth” properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed.
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Cites
Amphiphilic block copolymers for drug delivery
Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10397 · Cited by 1,078
Parameters influencing the stealthiness of colloidal drug delivery systems
Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740
The role of complement in biomaterial-induced inflammation
Nilsson, B., Ekdahl, K. N., Mollnes, T. E., & Lambris, J. D. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.06.020 · Cited by 431
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Cited by
Surface-Modified Nanocarriers for Nose-To-Brain Delivery: From Bioadhesion to Targeting
Sonvico, F., Clementino, A. R., Buttini, F., Colombo, G., Pescina, S., Stanisçuaski Guterres, S., Raffin Pohlmann, A., & Nicoli, S. (2018) · doi:10.20944/preprints201802.0077.v1 · Cited by 306
dos Santos Rodrigues, B., Oue, H., Banerjee, A., Kanekiyo, T., & Singh, J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.07.043 · Cited by 116
Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery
Wang, Y., van Steenbergen, M. J., Beztsinna, N., Shi, Y., Lammers, T., van Nostrum, C. F., & Hennink, W. E. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.013 · Cited by 66
Mosafer, J., Teymouri, M., Abnous, K., Tafaghodi, M., & Ramezani, M. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.11.053 · Cited by 60
Maxwell, T., Nogueira Campos, M. G., Smith, S., Doomra, M., Thwin, Z., & Santra, S. (2020) · Nanoparticles for Biomedical Applications · doi:10.1016/b978-0-12-816662-8.00015-1 · Cited by 43
Litti, L., Rivato, N., Fracasso, G., Bontempi, P., Nicolato, E., Marzola, P., Venzo, A., Colombatti, M., Gobbo, M., & Meneghetti, M. (2018) · Nanoscale · doi:10.1039/c7nr07398d · Cited by 33
Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15
Metadata
- Authors
- Salmaso, S., & Caliceti, P.
- Venue
- Journal of Drug Delivery
- Publisher
- Wiley
- Published
- 2013-03-07
- Volume
- 2013
- Pages
- 1-19
- ISSN
- 2090-3014 (ISSN-L)
- 2090-3022
- OpenAlex
- W2033999645
- Cited by
- 340
- References
- 4
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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