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Cited by 273Thyroid Disorders and TreatmentsDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index.

The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases

Open access
Wang, Chaoxun·2013·Journal of Diabetes Research
DOI 10.1155/2013/390534PMC PMC3647563
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Abstract

Type 2 diabetes mellitus (T2DM) has an intersecting underlying pathology with thyroid dysfunction. The literature is punctuated with evidence indicating a contribution of abnormalities of thyroid hormones to type 2 DM. The most probable mechanism leading to T2DM in thyroid dysfunction could be attributed to perturbed genetic expression of a constellation of genes along with physiological aberrations leading to impaired glucose utilization and disposal in muscles, overproduction of hepatic glucose output, and enhanced absorption of splanchnic glucose. These factors contribute to insulin resistance. Insulin resistance is also associated with thyroid dysfunction. Hyper- and hypothyroidism have been associated with insulin resistance which has been reported to be the major cause of impaired glucose metabolism in T2DM. The state-of-art evidence suggests a pivotal role of insulin resistance in underlining the relation between T2DM and thyroid dysfunction. A plethora of preclinical, molecular, and clinical studies have evidenced an undeniable role of thyroid malfunctioning as a comorbid disorder of T2DM. It has been investigated that specifically designed thyroid hormone analogues can be looked upon as the potential therapeutic strategies to alleviate diabetes, obesity, and atherosclerosis. These molecules are in final stages of preclinical and clinical evaluation and may pave the way to unveil a distinct class of drugs to treat metabolic disorders.

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Research works printed but not linked: 11

  1. 2001, Diabetes, 50, S169
  2. 1997, Diabetes Reviews, 5, 177
  3. 2012, Journal of Pharmacology and Pharmacotherapeutics, 3, 156
  4. 1980, Diabetologia, 19, 505
  5. 1996, Diabetes and Metabolism, 22, 299
  6. 10.1210/en.135.2.649 · DOI
  7. 1985, The American Journal of Physiology, 248, E593
  8. 10.1210/jc.87.2.630 · DOI
  9. 10.1038/nrd2830 · DOI · Paper page
  10. 10.1038/ncpendmet0590 · DOI
  11. 1994, Diabetes Research, 27, 15

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Metadata

Authors
Wang, C.
Affiliations
Fudan University (CN)
Corresponding author
Wang, Chaoxun
ORCID
Wang, Chaoxun
Venue
Journal of Diabetes Research
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-9
ISSN
  • 2314-6745 (ISSN-L)
  • 2314-6753
DOI
10.1155/2013/390534
PMC
PMC3647563
OpenAlex
W2134628308
Cited by
273
References
94
Citations by year
2026: 8 · 2025: 14 · 2024: 24 · 2023: 22 · 2022: 27 · 2021: 31 · 2020: 30 · 2019: 30 · 2018: 19 · 2017: 22 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 4
FWCI
12.09
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Diabetes Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
type 2 diabetes, thyroid dysfunction, hyperthyroidism, hypothyroidism, insulin resistance, thyroid hormones, glucose metabolism, hepatic glucose production, thyroid hormone analogs, obesity, atherosclerosis, metabolic disorders

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