Cited by 273Thyroid Disorders and TreatmentsDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

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The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases

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Wang, Chaoxun·2013·Journal of Diabetes Research

DOI 10.1155/2013/390534PMC PMC3647563

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Abstract

Type 2 diabetes mellitus (T2DM) has an intersecting underlying pathology with thyroid dysfunction. The literature is punctuated with evidence indicating a contribution of abnormalities of thyroid hormones to type 2 DM. The most probable mechanism leading to T2DM in thyroid dysfunction could be attributed to perturbed genetic expression of a constellation of genes along with physiological aberrations leading to impaired glucose utilization and disposal in muscles, overproduction of hepatic glucose output, and enhanced absorption of splanchnic glucose. These factors contribute to insulin resistance. Insulin resistance is also associated with thyroid dysfunction. Hyper- and hypothyroidism have been associated with insulin resistance which has been reported to be the major cause of impaired glucose metabolism in T2DM. The state-of-art evidence suggests a pivotal role of insulin resistance in underlining the relation between T2DM and thyroid dysfunction. A plethora of preclinical, molecular, and clinical studies have evidenced an undeniable role of thyroid malfunctioning as a comorbid disorder of T2DM. It has been investigated that specifically designed thyroid hormone analogues can be looked upon as the potential therapeutic strategies to alleviate diabetes, obesity, and atherosclerosis. These molecules are in final stages of preclinical and clinical evaluation and may pave the way to unveil a distinct class of drugs to treat metabolic disorders.

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Authors: Wang, C.
Affiliations: Fudan University (CN)
Corresponding author: Wang, Chaoxun
ORCID: Wang, Chaoxun
Venue: Journal of Diabetes Research
Publisher: Wiley
Published: 2013
Volume: 2013
Pages: 1-9
ISSN: 2314-6745 (ISSN-L)
2314-6753
DOI: 10.1155/2013/390534
PMC: PMC3647563
OpenAlex: W2134628308
Cited by: 273
References: 94
Citations by year: 2026: 8 · 2025: 14 · 2024: 24 · 2023: 22 · 2022: 27 · 2021: 31 · 2020: 30 · 2019: 30 · 2018: 19 · 2017: 22 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 4
FWCI: 12.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Journal of Diabetes Research (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: type 2 diabetes, thyroid dysfunction, hyperthyroidism, hypothyroidism, insulin resistance, thyroid hormones, glucose metabolism, hepatic glucose production, thyroid hormone analogs, obesity, atherosclerosis, metabolic disorders

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The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases

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