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Cited by 67Ovarian function and disordersAcupuncture Treatment Research StudiesReproductive Health and Technologies

Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial

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Kuang, Hongying, Li, Yan, Wu, Xiaoke, Hou, Lihui, Wu, Taixiang, Liu, Jianping, Ng, Ernest Hung Yu, Stener-Victorin, Elisabet +2 more·2013·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2013/527303PMC PMC3762180
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Abstract

Acupuncture is an alternative therapy to induce ovulation in women with polycystic ovary syndrome (PCOS), but there is no study reporting the live birth rate following ovulation induction by acupuncture or its potential as an adjuvant treatment to clomiphene citrate (CC). We assess the efficacy of acupuncture with or without CC in achieving live births among 1000 PCOS women in Mainland China. This paper reports the methodology of an ongoing multicenter randomized controlled trial. The randomization scheme is coordinated through the central mechanism and stratified by the participating sites. Participants will be randomized into one of the four treatment arms: (A) true acupuncture and CC, (B) control acupuncture and CC, (C) true acupuncture and placebo CC, and (D) control acupuncture and placebo CC. To ensure the quality and integrity of the trial we have developed a unique multinational team of investigators and Data and Safety Monitoring Board. Up to the end of April 2013, 326 subjects were recruited. In conclusion, the success of this trial will allow us to evaluate the additional benefit of acupuncture beyond the first line medicine for fertility treatment in PCOS women in an unbiased manner.

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Authors
Kuang, H., Li, Y., Wu, X., Hou, L., Wu, T., Liu, J., Ng, E. H. Y., Stener-Victorin, E., Legro, R. S., & Zhang, H.
Affiliations
  • Heilongjiang University of Chinese Medicine (CN)
  • Sichuan University (CN)
  • Beijing University of Chinese Medicine (CN)
  • Queen Mary Hospital (CN)
  • Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden
  • Pennsylvania State University (US)
  • Department of Biostatistics, Yale University School of Public Health, New Haven, CT 06511, USA
Corresponding author
Wu, Xiaoke
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Hindawi Limited
Published
2013
Volume
2013
Pages
1-11
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
DOI
10.1155/2013/527303
PMC
PMC3762180
OpenAlex
W2005980664
Cited by
67
References
2
Citations by year
2026: 8 · 2025: 7 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 1 · 2014: 2
FWCI
2.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
Funders
  • National Public Welfare Projects for Chinese Medicine (201107005)
  • State Administration of Traditional Chinese Medicine of China (201107005)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
acupuncture, clomiphene citrate, polycystic ovary syndrome, live birth rate, ovulation induction, infertility treatment, adjuvant therapy, randomized controlled trial design

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