Cited by 1,360Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Polycystic ovary syndrome

Norman, Robert J, Dewailly, Didier, Legro, Richard S, Hickey, Theresa E·2007·The Lancet

Abstract

Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. The major endocrine disruption is excessive androgen secretion or activity, and a large proportion of women also have abnormal insulin activity. Many body systems are affected in polycystic ovary syndrome, resulting in several health complications, including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes and a still debated increased risk of cardiovascular disease. The diagnostic traits of polycystic ovary syndrome are hyperandrogenism, chronic anovulation, and polycystic ovaries, after exclusion of other conditions that cause these same features. A conclusive definition of the disorder and the importance of the three diagnostic criteria relative to each other remain controversial. The cause of polycystic ovary syndrome is unknown, but studies suggest a strong genetic component that is affected by gestational environment, lifestyle factors, or both.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(07)61345-2

Cites

179 of 179 references verified0 citation errors · 0 not checkable

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Authors
Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E.
Affiliations
  • The University of Adelaide (AU)
  • Centre Hospitalier Universitaire de Lille (FR)
  • Pennsylvania State University (US)
Corresponding author
Hickey, Theresa E
Venue
The Lancet
Publisher
Elsevier BV
Published
2007-08
Volume
370
Issue
9588
Pages
685-697
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2499178053
Cited by
1,360
References
181
Citations by year
2026: 43 · 2025: 61 · 2024: 100 · 2023: 100 · 2022: 101 · 2021: 105 · 2020: 94 · 2019: 86 · 2018: 86 · 2017: 74 · 2016: 78 · 2015: 70 · 2014: 62 · 2013: 52 · 2012: 60
FWCI
6.99
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, hyperandrogenism, insulin resistance, menstrual disorders, infertility, hirsutism, acne, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, diagnostic criteria, chronic anovulation, polycystic ovary, genetic susceptibility, lifestyle factors

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