Polycystic ovary syndrome
Abstract
Polycystic ovary syndrome is a heterogeneous endocrine disorder that affects about one in 15 women worldwide. The major endocrine disruption is excessive androgen secretion or activity, and a large proportion of women also have abnormal insulin activity. Many body systems are affected in polycystic ovary syndrome, resulting in several health complications, including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes and a still debated increased risk of cardiovascular disease. The diagnostic traits of polycystic ovary syndrome are hyperandrogenism, chronic anovulation, and polycystic ovaries, after exclusion of other conditions that cause these same features. A conclusive definition of the disorder and the importance of the three diagnostic criteria relative to each other remain controversial. The cause of polycystic ovary syndrome is unknown, but studies suggest a strong genetic component that is affected by gestational environment, lifestyle factors, or both.
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Insulin resistance and associated hyperinsulinaemia play a role in the reproductive and endocrine features of PCOS by contributing to hyperandrogenism and disruption of gonadotrophin secretion.
“IR and associated hyperinsulinaemia play a role in the reproductive, and endocrine features of PCOS by contributing to hyperandrogenism and disruption of gonadotrophin secretion (Norman et al., 2007).”
From Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic–hyperinsulinaemic clamp studies (2016) · cites this paper as Norman et al., 2007
PCOS has potential for major metabolic consequences, including obesity and related type 2 diabetes mellitus (DM2) as well as cardiovascular disease (CVD).
“PCOS has potential for major metabolic consequences, including obesity and related type 2 diabetes mellitus (DM2) as well as cardiovascular disease (CVD)”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [3]
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- Authors
- Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E.
- Affiliations
- The University of Adelaide (AU)
- Centre Hospitalier Universitaire de Lille (FR)
- Pennsylvania State University (US)
- Corresponding author
- Hickey, Theresa E
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 370
- Issue
- 9588
- Pages
- 685-697
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2499178053
- Cited by
- 1,360
- References
- 181
- Citations by year
- 2026: 43 · 2025: 61 · 2024: 100 · 2023: 100 · 2022: 101 · 2021: 105 · 2020: 94 · 2019: 86 · 2018: 86 · 2017: 74 · 2016: 78 · 2015: 70 · 2014: 62 · 2013: 52 · 2012: 60
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, hyperandrogenism, insulin resistance, menstrual disorders, infertility, hirsutism, acne, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, diagnostic criteria, chronic anovulation, polycystic ovary, genetic susceptibility, lifestyle factors
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