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Cited by 81Connective tissue disorders researchMusculoskeletal pain and rehabilitationFibromyalgia and Chronic Fatigue Syndrome Research

Evaluation of Kinesiophobia and Its Correlations with Pain and Fatigue in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility Type

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Celletti, Claudia, Castori, Marco, La Torre, Giuseppe, Camerota, Filippo·2013·BioMed Research International
DOI 10.1155/2013/580460PMC PMC3725998
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Abstract

Ehlers-Danlos syndrome hypermobility type a. k. a. joint hypermobility syndrome (JHS/EDS-HT) is a hereditary musculoskeletal disorder associating generalized joint hypermobility with chronic pain. Anecdotal reports suggest a prominent role for kinesiophobia in disease manifestations, but no study has systematically addressed this point. Objective . To investigate the impact of kinesiophobia and its relationship with pain, fatigue, and quality of life in JHS/EDS-HT. Design . Cross-sectional study. Subjects/Patients . 42 patients (40 female and 2 male) with JHS/EDS-HT diagnosis following standardized diagnostic criteria were selected. Methods . Disease features were analyzed by means of specific questionnaires and scales evaluating kinesiophobia, pain, fatigue, and quality of life. The relationships among variables were investigated using the Spearman bivariate analysis. Results . Kinesiophobia resulted predominantly in the patients’ sample. The values of kinesiophobia did not correlate with intensity of pain, quality of life, and (or) the single component of fatigue. A strong correlation was discovered between kinesiophobia and general severity of fatigue. Conclusions . In JHS/EDS-HT, the onset of pain-avoiding strategies is related to the presence of pain but not to its intensity. The clear-cut correlation between kinesiophobia and severity of fatigue suggests a direct link between musculoskeletal pain and fatigue. In JHS/EDS-HT, the underlying mechanism is likely to be facilitated by primary disease characteristics, including hypotonia.

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Authors
Celletti, C., Castori, M., La Torre, G., & Camerota, F.
Affiliations
  • Policlinico Umberto I (IT)
  • Azienda Ospedaliera San Camillo-Forlanini (IT)
  • Department of Public Health and Infectious Diseases, Sapienza University, Umberto I Hospital, 00185 Rome, Italy
Corresponding author
Celletti, Claudia
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-7
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2013/580460
PMC
PMC3725998
OpenAlex
W1967503689
Cited by
81
References
9
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 1
FWCI
2.88
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Keywords
kinesiophobia, joint hypermobility syndrome, Ehlers-Danlos syndrome hypermobility type, chronic musculoskeletal pain, fatigue, quality of life, hypotonia, hereditary connective tissue disorders
MeSH terms
Aged, Cross-Sectional Studies, Ehlers-Danlos Syndrome, Fatigue, Female, Humans, Joint Instability, Joints, Male, Middle Aged, Quality of Life, Chronic Pain

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