Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome – hypermobility type

Krahe, Anne Maree; Adams, Roger David; Nicholson, Leslie Lorenda

doi:10.1080/09638288.2017.1323022

Cited by 54Connective tissue disorders researchFibromyalgia and Chronic Fatigue Syndrome ResearchMusculoskeletal pain and rehabilitation

Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome – hypermobility type

Krahe, Anne Maree, Adams, Roger David, Nicholson, Leslie Lorenda·2018·Disability and Rehabilitation

DOI 10.1080/09638288.2017.1323022

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Abstract

AIM: To assess the prevalence, severity and impact of fatigue on individuals with joint hypermobility syndrome (JHS)/Ehlers-Danlos syndrome - hypermobility type (EDS-HT) and establish potential determinants of fatigue severity in this population. METHODS: Questionnaires on symptoms and signs related to fatigue, quality of life, mental health, physical activity participation and sleep quality were completed by people with JHS/EDS-HT recruited through two social media sites. Multiple regression analysis was performed to identify predictors of fatigue in this population. RESULTS: Significant fatigue was reported by 79.5% of the 117 participants. Multiple regression analysis identified five predictors of fatigue severity, four being potentially modifiable, accounting for 52.3% of the variance in reported fatigue scores. Predictors of fatigue severity were: the self-perceived extent of joint hypermobility, orthostatic dizziness related to heat and exercise, levels of participation in personal relationships and community, current levels of physical activity and dissatisfaction with the diagnostic process and management options provided for their condition. CONCLUSION: Fatigue is a significant symptom associated with JHS/EDS-HT. Assessment of individuals with this condition should include measures of fatigue severity to enable targeted management of potentially modifiable factors associated with fatigue severity. Implications for rehabilitation Fatigue is a significant symptom reported by individuals affected by joint hypermobility syndrome/Ehlers-Danlos syndrome - hypermobility type. Potentially modifiable features that contribute to fatigue severity in this population have been identified. Targeted management of these features may decrease the severity and impact of fatigue in joint hypermobility syndrome/Ehlers-Danlos syndrome - hypermobility type.

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Chronic fatigue symptoms are common in HSD/hEDS.
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From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [84]
Integrated care of patients with irritable bowel syndrome and other DGBI has been shown to improve health-related quality of life, patient psychological wellbeing and other outcomes.
“While evidence for timely, collaborative care is limited in the HSD/hEDS population, integrated care of patients with irritable bowel syndrome and other DGBI have been shown to improve health‐related quality of life, patient psychological wellbeing and other outcomes. 84 , 85”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [84]

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Relationship between fatigue and gait abnormality in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome Hypermobility type
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Authors: Krahe, A. M., Adams, R. D., & Nicholson, L. L.
Affiliations: The University of Sydney (AU)
Corresponding author: Krahe, Anne Maree
ORCID: Adams, Roger David
Nicholson, Leslie Lorenda
Venue: Disability and Rehabilitation
Publisher: Informa UK Limited
Published: 2017-05-09
Volume: 40
Issue: 17
Pages: 1989-1996
ISSN: 0963-8288 (ISSN-L)
1464-5165
DOI: 10.1080/09638288.2017.1323022
OpenAlex: W2612466979
Cited by: 54
References: 42
Citations by year: 2025: 7 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 25 · 2020: 6 · 2019: 4 · 2018: 3
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Locations: Disability and Rehabilitation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords: fatigue, joint hypermobility syndrome, Ehlers-Danlos syndrome hypermobility type, fatigue severity, predictors of fatigue, orthostatic dizziness, physical activity, social participation (health and rehabilitation), quality of life, sleep quality, mental health
MeSH terms: Adult, Australia, Ehlers-Danlos Syndrome, Fatigue, Female, Humans, Joint Instability, Male, Mental Health, Middle Aged, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Exercise, Prevalence, Multivariate Analysis, Orthostatic Intolerance

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Features that exacerbate fatigue severity in joint hypermobility syndrome/Ehlers–Danlos syndrome – hypermobility type

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