The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dental Enamel Development: Proteinases and Their Enamel Matrix Substrates
Open accessAbstract
This review focuses on recent discoveries and delves in detail about what is known about each of the proteins (amelogenin, ameloblastin, and enamelin) and proteinases (matrix metalloproteinase-20 and kallikrein-related peptidase-4) that are secreted into the enamel matrix. After an overview of enamel development, this review focuses on these enamel proteins by describing their nomenclature, tissue expression, functions, proteinase activation, and proteinase substrate specificity. These proteins and their respective null mice and human mutations are also evaluated to shed light on the mechanisms that cause nonsyndromic enamel malformations termed amelogenesis imperfecta.Pertinent controversies are addressed. For example, do any of these proteins have a critical function in addition to their role in enamel development? Does amelogenin initiate crystallite growth, does it inhibit crystallite growth in width and thickness, or does it do neither? Detailed examination of the null mouse literature provides unmistakable clues and/or answers to these questions, and this data is thoroughly analyzed. Striking conclusions from this analysis reveal that widely held paradigms of enamel formation are inadequate. The final section of this review weaves the recent data into a plausible new mechanism by which these enamel matrix proteins support and promote enamel development.
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Tjäderhane, L., Buzalaf, M. A. R., Carrilho, M., & Chaussain, C. (2015) · Caries Research · doi:10.1159/000363582 · Cited by 2,306
Kawasaki, K., & Weiss, K. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0638023100 · Cited by 314
Genetic basis for the evolution of vertebrate mineralized tissue
Kawasaki, K., Suzuki, T., & Weiss, K. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404279101 · Cited by 212
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Abou Neel, E., Aljabo, A., Strange, A., Ibrahim, S., Coathup, M., Young, A., Bozec, L., & Mudera, V. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s107624 · Cited by 697
Molecular and cellular mechanisms of tooth development, homeostasis and repair
Yu, T., & Klein, O. D. (2020) · Development · doi:10.1242/dev.184754 · Cited by 267
Karayasheva, D., Glushkova, M., Boteva, E., Mitev, V., & Kadiyska, T. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.03.007 · Cited by 21
Metadata
- Authors
- Bartlett, J. D.
- Venue
- ISRN Dentistry
- Publisher
- Wiley
- Published
- 2013-09-16
- Volume
- 2013
- Pages
- 1-24
- ISSN
- 2090-4371 (ISSN-L)
- 2090-438X
- OpenAlex
- W2055985848
- Cited by
- 245
- References
- 3
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- diamond
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