Cited by 445Cardiac Health and Mental HealthAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.

Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.

Open access

Huffman, Jeff C., Celano, Christopher M., Beach, Scott R., Motiwala, Shweta R., Januzzi, James L.·2013·Cardiovascular Psychiatry and Neurology

DOI 10.1155/2013/695925PMC PMC3638710

Open this paper in CoChat — free account Open PDF

Abstract

In patients with cardiovascular disease (CVD), depression is common, persistent, and associated with worse health-related quality of life, recurrent cardiac events, and mortality. Both physiological and behavioral factors-including endothelial dysfunction, platelet abnormalities, inflammation, autonomic nervous system dysfunction, and reduced engagement in health-promoting activities-may link depression with adverse cardiac outcomes. Because of the potential impact of depression on quality of life and cardiac outcomes, the American Heart Association has recommended routine depression screening of all cardiac patients with the 2- and 9-item Patient Health Questionnaires. However, despite the availability of these easy-to-use screening tools and effective treatments, depression is underrecognized and undertreated in patients with CVD. In this paper, we review the literature on epidemiology, phenomenology, comorbid conditions, and risk factors for depression in cardiac disease. We outline the associations between depression and cardiac outcomes, as well as the mechanisms that may mediate these links. Finally, we discuss the evidence for and against routine depression screening in patients with CVD and make specific recommendations for when and how to assess for depression in this high-risk population.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2013/695925

Cites

176 of 176 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1092 · Cited by 31,765
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2003) · Medical Care · doi:10.1097/01.mlr.0000093487.78664.3c · Cited by 6,359
An Ultra-Brief Screening Scale for Anxiety and Depression: The PHQ–4
Kroenke, K., Spitzer, R. L., Williams, J. B. W., & Löwe, B. (2009) · Psychosomatics · doi:10.1016/s0033-3182(09)70864-3 · Cited by 4,261
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198409273111303 · Cited by 3,125
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Depression Following Myocardial Infarction
Frasure‐Smith, N. (1993) · JAMA · doi:10.1001/jama.1993.03510150053029 · Cited by 2,039

Flagged first, then by citations

Show all 176 references

Research works printed but not linked: 6

2012, Current Cardiovascular Risk Reports, 5, 510
2011, Cardiology Journal, 18, 18
10.1176/appi.psy.50.6.613 · DOI · Paper page
1991, The American Journal of Pathology, 138, 951
2009, European Review for Medical and Pharmacological Sciences, 13, 299
1988, Circulation, 78, 969

Sorted by citations

Items 201–300 of 445

Community‐Based Evaluation of the Associations Between Well‐Being and Cardiovascular Disease Risk
McLeish, A. C., Smith, T., Riggs, D. W., Hart, J. L., Walker, K. L., Keith, R. J., Anderson, L. B., Sithu, I. D., Pinilla‐Baquero, J., Srivastava, S., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027095 · Cited by 9
Do socioeconomic factors modify the association between preoperative antidepressant use and survival following coronary artery bypass surgery?
Stenman, M., Holzmann, M. J., & Sartipy, U. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.125 · Cited by 9
The Impact of Depression and Anxiety on Cardiovascular Disease Risk and Outcomes in Women
Mosarla, R. C., & Wood, M. J. (2021) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-020-00889-9 · Cited by 9
Tricyclic and SSRI usage influences the association between BMI and health risk factors
Serodio, K., Ardern, C. I., Rotondi, M. A., & Kuk, J. L. (2014) · Clinical Obesity · doi:10.1111/cob.12067 · Cited by 10
The role of inflammation and oxidative stress in depression and cardiovascular disease
Wood, S. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00008-8 · Cited by 9
Depressive symptoms occurring after stroke by age, sex and socioeconomic status in six population-based studies: Longitudinal analyses and meta-analyses
Peng, L., Zhang, J., Li, N., Jin, Y., & Zheng, Z. (2022) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2022.103397 · Cited by 8
Depressive symptoms, its sub-factors, and augmentation index: the modifying effects according to inflammatory markers
Jeon, Y. J., Cho, S. M. J., Lee, Y. J., Kim, H. C., & Jung, S. J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.174 · Cited by 8
Effects of cognitive behavioral therapy on depression, anxiety, sleep and quality of life for patients with heart failure and coronary heart disease. a systematic review of clinical trials 2010 – 2020
Pizga, A., Kordoutis, P., Tsikrika, S., Vasileiadis, I., Nanas, S., & Karatzanos, E. (2021) · Health & Research Journal · doi:10.12681/healthresj.27572 · Cited by 8
Depression and adherence to healthy lifestyle behaviors among patients with coronary artery diseases in Jordan
Al-Zaru, I. M., Shahrour, G., Masha’al, D., & Hayajneh, A. A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09752 · Cited by 8
Ischemic Heart Disease as an Important Risk Factor for Depression—A Case Report
Bondar, L. I., Osser, B., Osser, G., Mariș, M. A., Piroș, E. L., Almășan, R., & Popescu, M. I. (2024) · Applied Sciences · doi:10.3390/app14051969 · Cited by 8
Background Stress Inventory: Developing a Measure of Understudied Stress
Terrill, A. L., Gjerde, J. M., & Garofalo, J. P. (2013) · Stress and Health · doi:10.1002/smi.2554 · Cited by 8
Impaired ability to grow colonies of endothelial stem cells could be the mechanism explaining the high cardiovascular morbidity and mortality of patients with depression
Blum, A., Pastuck, N., Zaroura, I., Rotem, J., & Kamal, F. (2017) · QJM · doi:10.1093/qjmed/hcx059 · Cited by 8
Social support in maintaining mental health and quality of life among community-dwelling older people with functional limitations in Malaysia: a population-based cross-sectional study
Balqis-Ali, N. Z., & Fun, W. H. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-077046 · Cited by 12
Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress
O’Regan, G., Plummer, Z., Christie, B. R., Shultz, S. R., & Allen, J. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03717-2 · Cited by 11
A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Banerjee, P., Chau, K. M., Kotla, S., Davis, E. L., Turcios, E. B., Li, S., Zhang, P., Wang, G., Kolluru, G. K., Jain, A., et al. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01223-5 · Cited by 7
Prophylactic antidepressant treatment following acute coronary syndrome: A systematic review of randomized controlled trials
Grummedal, O., Madsen, M. T., Simonsen, E. H., & Gögenür, I. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.016 · Cited by 7
Clinical depression among patients after acute coronary syndrome: a prospective single-tertiary centre analysis
Leong, L., Zuhdi, A. S. M., & Hafidz, M. A. (2020) · Singapore Medical Journal · doi:10.11622/smedj.2020079 · Cited by 7
A Cardiovascular Risk Assessment Model According to Behavioral, Psychosocial and Traditional Factors in Patients With ST-Segment Elevation Myocardial Infarction (CRAS-MI): Review of Literature and Methodology of a Multi-Center Cohort Study
Roohafza, H., Noohi, F., Hosseini, S. G., Alemzadeh‐Ansari, M. J., Bagherieh, S., Marateb, H. R., Mansourian, M., Mousavi, A. F., Seyedhosseini, M., Farshidi, H., et al. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101158 · Cited by 7
Forebrain corticosteroid receptors promote post-myocardial infarction depression and mortality
Bruns, B., Daub, R., Schmitz, T., Sinno, M. H., Spaich, S., Dewenter, M., Schwale, C., Gass, P., Vogt, M. A., Katus, H. A., et al. (2022) · Basic Research in Cardiology · doi:10.1007/s00395-022-00951-6 · Cited by 7
Cardiorespiratory fitness and cardiovascular risk among in-patients with depression compared to healthy controls
Gerber, M., Cody, R., Beck, J., Brand, S., Donath, L., Eckert, A., Hatzinger, M., Imboden, C., Kreppke, J.-N., Lang, U. E., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1193004 · Cited by 8
The relationship between heart and ‘inner self’ from Aristotle to current clinical practice
Goodhart, A. K. (2013) · Medical Humanities · doi:10.1136/medhum-2013-010392 · Cited by 7
Identifying and managing depression in patients with coronary artery disease
Pragle, A. S., & Salahshor, S. (2018) · JAAPA · doi:10.1097/01.jaa.0000532111.83132.8b · Cited by 8
Effect of gender and diabetes on major depressive disorder using heart rate asymmetry
Karmakar, C. K., Jelinek, H. F., Warner, P., Khandoker, A. H., & Palaniswami, M. S. (2014) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2014.6945160 · Cited by 7
Is Symptomatic Long QT Syndrome Associated with Depression in Women and Men?
Wesołowska, K., Elovainio, M. J., Koponen, M., Tuiskula, A. M., Hintsanen, M., Keltikangas‐Järvinen, L., Määttänen, I., Swan, H., & Hintsa, T. (2016) · Journal of Genetic Counseling · doi:10.1007/s10897-016-0004-4 · Cited by 7
Do patients take angioplasty seriously?
Astin, F. (2017) · European Journal of Cardiovascular Nursing · doi:10.1177/1474515117737767 · Cited by 7
Incidence, characteristics and outcomes of out-of-hospital cardiac arrests in patients with psychiatric illness: A systematic review
Alotaibi, R. N., Halbesma, N., Bijman, L., Clegg, G. R., Smıth, D. J., & Jackson, C. (2022) · Resuscitation Plus · doi:10.1016/j.resplu.2022.100214 · Cited by 6
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_88 · Cited by 6
Associations between psychosocial burden and prognostic biomarkers in patients with chronic coronary syndrome: a STABILITY substudy
Wassberg, C., Batra, G., Hadziosmanovic, N., Hagström, E., White, H. D., Stewart, R., Siegbahn, A. G., Wallentin, L. C., & Held, C. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae252 · Cited by 6
Prehabilitation for people undergoing cardiac surgery
Skorupska, N., Perry, R., Collis, P., Dawson, S., Taylor, R. S., Cleland, J. G., Akowuah, E., Gibbison, B., Murphy, G. J., Levett, D., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015336 · Cited by 7
Depression as a risk factor for cardiac illness – What do we know about?
Padhy, S. K., Sarkar, S., Davuluri, T., & Malhotra, N. (2015) · Journal of Indian College of Cardiology · doi:10.1016/j.jicc.2015.02.004 · Cited by 6
Impaired ability to grow colonies of endothelial stem cells could be the mechanism explaining the high cardiovascular morbidity and mortality of patients with depression
Blum, A., Pastukh, N., Zaroura, I., Rotem, J., & Kamal, F. (2018) · QJM · doi:10.1093/qjmed/hcx245 · Cited by 6
Basic lifestyle advice to individuals at high risk of type 2 diabetes: a 2-year population-based diabetes prevention study. The DE-PLAN intervention in the HUNT Study, Norway
Jølle, A., Åsvold, B. O., Holmen, J., Carlsen, S. M., Tuomilehto, J. O., Bjø‌rngaard, J. H., & Midthjell, K. (2018) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2018-000509 · Cited by 7
Percepções dos Participantes de Reabilitação Cardíaca sobre seus Comportamentos em Saúde e Necessidades de Informação durante a Pandemia COVID-19 no Brasil
Ghisi, G. L. D. M., dos Santos, R. Z., Körbes, A. S., de Souza, C. A., Karsten, M., OH, P. I., & Benetti, M. (2022) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20210447 · Cited by 6
Nutrition and Neuroinflammation: Are Middle-Aged Women in the Red Zone?
Bernier, V., Chatelan, A., Point, C., & Strauss, M. (2025) · Nutrients · doi:10.3390/nu17101607 · Cited by 6
Understanding the Relationship Between Comorbidities, Medication Nonadherence, Activities of Daily Living, and Heart Condition Status Among Older Adults in the United States: A Regression Analysis and Machine Learning Approach
Ruksakulpiwat, S., Thongking, W., Kannan, N., Wright, E., Niyomyart, A., Benjasirisan, C., Chiaranai, C., Smothers, C. G., Aldossary, H. M., & Still, C. H. (2024) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000001150 · Cited by 5
Inhibiting Monoamine Oxidase in CNS and CVS would be a Promising Approach to Mitigating Cardiovascular Complications in Neurodegenerative Disorders
Srivastava, P., Sudevan, S. T., Arumugam, T., Mathew, B., & Kanthlal, S. K. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230303115236 · Cited by 5
The Impact of Mental Health on Patient Outcomes in Peripheral Arterial Disease and Critical Limb Threatening Ischemia and Potential Avenues to Treatment
McElroy, I. E., Suarez, L. B., & Tan, T. (2024) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2024.01.028 · Cited by 5
Impact of Depressive Disorder on Access and Quality of Care in Veterans With Prevalent Cardiovascular Disease
Srivastava, P., Butler, J., Shroyer, A. L., Lacey, M. J., & Parikh, P. B. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.02.048 · Cited by 5
Severe Depressive Episode with Psychotic Symptoms and Type 2 Diabetes: A 2010–2017 Longitudinal Study
Jaworski, M., Pańczyk, M., Śliwczyński, A. M., Brzozowska, M., Janaszek, K., Małkowski, P., & Gotlib, J. (2019) · Medical Science Monitor · doi:10.12659/msm.913356 · Cited by 5
Thyroid Hormones, Brain, and Heart
Burkauskas, J., Pranckevičienė, A., & Bunevičius, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-36871-5_25 · Cited by 6
A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder
Liu, W., Zheng, Y., Zhang, F., Zhu, M., Guo, Q., Xu, H. J., Liu, C., Chen, H., Wang, X., Hu, Y. F., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.627469 · Cited by 6
Association Between Depressive Symptoms and Cardiac Structure and Function in a Peruvian Population
Santiago, C., Peña, M. S. B., Brown, T., Shakil, S. S., Januzzi, J. L., Velazquez, E. J., Miranda, J. J., Rivera, D., & Checkley, W. (2022) · Global Heart · doi:10.5334/gh.981 · Cited by 5
Using longitudinal prescription data to examine the incidence of other chronic diseases following antidepressant use
Teng, A., Taylor, Z., Pfeffer, J., & Williams, L. M. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.030 · Cited by 5
Bright light therapy for depressive symptoms in hospitalized cardiac patients: A randomized controlled pilot trial
Eisenberg, M. J., Habib, B., Alcaraz, M., Thombs, B. D., & Filion, K. B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230839 · Cited by 5
Usage Patterns of the Calm Meditation App Among People with Cardiovascular Disease
Luberto, C. M., Huberty, J. L., Puzia, M., & Vranceanu, A.-M. (2021) · Mindfulness · doi:10.1007/s12671-020-01567-4 · Cited by 3
Improving Depression Detection and Measuring Its Impact upon Short-Term Survival in Chronic Limb-Threatening Ischemia
Köksoy, C., Ruiz, I. P. T., Ooi, X. Y., Pallister, Z. S., Gilani, R. S., Mills, J. L., & Chung, J. (2025) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2025.02.015 · Cited by 4
The short-term effect of weather variables on heart rate variability in patients after open-heart surgery
Venclovienė, J., Beresnevaitė, M., Čerkauskaitė, S., Grižas, V., Kriukelytė, D., & Benetis, R. (2022) · International Journal of Environmental Health Research · doi:10.1080/09603123.2022.2087864 · Cited by 4
Serum Vitamin Levels, Cardiovascular Disease Risk Factors, and Their Association with Depression in Korean Women: A Cross-Sectional Study of a Nationally Representative Sample
Lee, S., & Baek, J. C. (2023) · Medicina · doi:10.3390/medicina59122183 · Cited by 4
Detrimental Impact of Comorbid Mental Disorders in Chronic Thromboembolic Pulmonary Hypertension ― A Retrospective Observational Study ―
Adachi, T., Adachi, S., Nakano, Y., Yasuda, K., Nishiyama, I., Hirose, M., & Murohara, T. (2024) · Circulation Reports · doi:10.1253/circrep.cr-23-0074 · Cited by 4
The depression-heart connection: cardiovascular risks in cancer patients from NHANES 2005–2018
Chen, Z., Qiu, X., Chi, H., & Rong, J. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06727-1 · Cited by 4
Use of serotonin reuptake inhibitors is not associated with increased bleeding after CABG
Heimisdóttir, A. A., Enger, E., Morelli, S., Jóhannesdóttir, H., Helgadóttir, S., Sigurðsson, E., & Guðbjartsson, T. (2020) · General Thoracic and Cardiovascular Surgery · doi:10.1007/s11748-020-01353-y · Cited by 4
Influence of Initial Severity of Depression on the Effectiveness of a Multimodal Therapy on Depressive Score, Heart Rate Variability, and Hemodynamic Parameters
Ketelhut, S., Wehlan, E., Bayer, G., & Ketelhut, R. G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169836 · Cited by 4
Identifying Predictors of Psychological Problems Among Adolescents With Congenital Heart Disease for Referral to Psychological Care: A Pilot Study
Gosnell, J. M., Finn, M. T. M., Marckini, D. N., Molla, A., & Sowinski, H. A. (2022) · CJC Pediatric and Congenital Heart Disease · doi:10.1016/j.cjcpc.2022.12.001 · Cited by 4
Effect of Anxiety and Depressive Symptoms on Quality of Life among Patients with Heart Failure: An integrative literature review
AbuRuz, M. E., Alemoush, R. A., & Momani, A. (2022) · Eastern Journal of Healthcare · doi:10.31557/ejhc.2022.2.1.36-43 · Cited by 4
Association between depression and blood pressure in community-dwelling older adults: focus on Bushehr elderly health (BEH) program
Farhadi, A., Javadian, H., Vahedparast, H., Marzban, M., Nemati, R., Larijani, B. A., & Nabipour, I. (2023) · BMC Public Health · doi:10.1186/s12889-023-16288-1 · Cited by 5
Measurement
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0002 · Cited by 5
There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers
Cai, S., Coates, A. M., Buckley, J. D., Berry, N., Burres, L., Beltrame, J. F., Howe, P. R. C., & Schrader, G. D. (2016) · Heart Lung and Circulation · doi:10.1016/j.hlc.2016.07.003 · Cited by 7
Correlates of memory loss and depression among myocardial infarction patients in Al-Qassim, Saudi Arabia
Saquib, J., Alromaih, N., AlMutairi, H., Alenazi, R. N., Al-Mutairi, R. D. A., AlHtlani, D. J., Altheyab, F., Alhsaon, M. A., Imran, M., Khalaf, H., et al. (2018) · Journal of the Saudi Heart Association · doi:10.1016/j.jsha.2018.04.001 · Cited by 4
Mental Disorders and Personal Psychological Characteristics in Patients with Cardiovascular Diseases
Петрова, Н. Н. (2019) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2019-4.1.12 · Cited by 4
Metacognitive Short-Term Intervention in Patients With Mental Disorders Following Cardiovascular Events
Gebhardt, P., Caldarone, F., Westhoff-Bleck, M., Olsson, K. M., Hoeper, M. M., Park, D.-H., Stapel, B., Breitner, M. H., Werth, O., Heitland, I., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.812807 · Cited by 3
Depression and Oxidative Stress Interaction in Stable Coronary Heart Disease
Ivaščenko, T., Voicehovskis, V., Kalējs, O., Voicehovska, J., Šķesters, A., Pahomova, N., & Lejnieks, A. (2022) · Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences · doi:10.2478/prolas-2022-0028 · Cited by 3
Understanding the Religion, Mental, and Social Health Relationship
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0016 · Cited by 7
Impact of collaborative care model treatment for depression and anxiety on cardiovascular risk factors using electronic health record data
Carroll, A. J., Philbin, S. E., Sanuade, O. A., Fu, E. S., Carlo, A. D., Pedamallu, H., Borisuth, S., Rosenthal, L. J., Rado, J. T., Jordan, N., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119720 · Cited by 3
Incident depression increases medical utilization in Medicaid patients with hypertension
Breunig, I. M., Shaya, F. T., Tevie, J., & Roffman, D. S. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.969712 · Cited by 3
Inhibitory Effect of Citalopram on the Pharmacokinetics of Carvedilol in Rats and in vitro Models
Abrudan, M. B., Muntean, D. M., Popa, D., Gheldiu, A.-M., Maria Adriana, N. E. A. G., & Vlase, L. (2017) · Pharmacology · doi:10.1159/000480090 · Cited by 3
Oxidative stress, depression, and risk of recurrence of stable coronary heart disease
Ivaščenko, T., Voicehovskis, V., Voicehovska, J., Šķesters, A., Apsīte, K., Grigorjeva, J., Ķīvīte‐Urtāne, A., Pahomova, N., & Kalējs, O. (2021) · Cor et Vasa · doi:10.33678/cor.2021.046 · Cited by 3
Association between Behavioral Flexibility and Psychological Distress in Patients with Cardiovascular Disease
Habibović, M., Widdershoven, J. W. M. G., Wetzels, M., Piera-Jiménez, J., & Kop, W. J. (2021) · Heart and Mind · doi:10.4103/hm.hm_15_21 · Cited by 4
Depression and Associated Factors in Patients with Implantable Cardioverter-Defibrillators.
Farahani, M. M., Taghipour, M., Motalebi, M., Bakhshian, R., Shahverdi, E., Taghipour, S., Abdi, S., & Moradi, R. (2016) · PubMed Central · Cited by 3
Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK BiobankPreprint
Howard, D. M., Hall, L. S., Hafferty, J. D., Zeng, Y., Adams, M. J., Clarke, T., Porteous, D. J., Nagy, R., Hayward, C., Smith, B. H., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/068643 · Cited by 3
Research trends in cardiac rehabilitation following COVID-19: A cross-sectional bibliometric study
Abdelwahab, S. İ., Taha, M. M. E., Bakhsh, H. R., & Aldhahi, M. I. (2025) · Medicine · doi:10.1097/md.0000000000046028 · Cited by 2
Mechanisms and Clinical Implications of the Post-traumatic Stress Disorder (PTSD)–Cardiovascular Disease Link
Sidik, A. I., Dontsov, V. V., Ruchkin, M. G., Kapieva, N. S., Alimagomaev, B. M., Epimakhova, O. S., Toktarova, N. M., BADOIAN, A. A., Falchinsky, A. N., Kirkevich, N. D., et al. (2025) · Cureus · doi:10.7759/cureus.100349 · Cited by 3
Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort
Clarke, K. A., Deng, Z., & Dickerson, A. S. (2025) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaf275 · Cited by 2
Caregiver burden in informal caregivers of cardiac patients: a mixed-methods systematic review
Beheshtaeen, F., Molazem, Z., Kalyani, M. N., Mohebbi, Z., Moshfeghinia, R., & Rad, M. G. (2026) · BMC Psychology · doi:10.1186/s40359-026-03973-0 · Cited by 4
Modern tendencies in the use of information and telecommunication technologies in the treatment of patients with cardiovascular diseases
Bockeria, L. A., Sokolskaya, M. A., & Shvartz, V. A. (2021) · Clinical Medicine (Russian Journal) · doi:10.30629/0023-2149-2020-98-9-10-656-664 · Cited by 2
Thermodynamics of solubility, distribution and permeability processes exemplified by nadolol – A beta-blocker drug with antianxiety potential
Volkova, Т. V., Simonova, O. R., Vigurskaya, T. A., & Perlovich, G. L. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.122307 · Cited by 2
Depression and Anxiety in Women with Coronary Artery Disease: Prevalence and Links to Adverse Cardiac Outcomes
Bouchard, K., Chiarelli, A., Dans, M., & Tulloch, H. E. (2023) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-39928-2_19 · Cited by 2
Psychological Well-Being and Positive Emotions
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0012 · Cited by 2
Case Study : Prognosis of Recurrent Depressive Disorder with Somatic Symptoms
Laila, F. N., Algristian, H., & Azizah, N. (2023) · International Islamic Medical Journal · doi:10.33086/iimj.v5i1.4454 · Cited by 2
Burden and Predictors of Depression in Populations With Coronary Heart Disease
Ilori, E. O., Erechukwu, C., Obitulata-Ugwu, V. O., Ewuzie, Z. D. D., Okobi, O. E., & Iyun, O. B. (2024) · Cureus · doi:10.7759/cureus.62068 · Cited by 2
Psychosocial Management of Patients with Heart Disease
Millstein, R. A., & Huffman, J. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-29294-6_10 · Cited by 2
Mild Depressive Symptoms Predict Mortality from Heart Failure in Elderly Men but Not Women
Luck‐Sikorski, C., Luppa, M., Heser, K., Bleckwenn, M., Posselt, T., Ernst, A., Werle, J., Weeg, D., Mösch, E., Wiese, B., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13802 · Cited by 2
Self-determination theory-based perceptions of community dwelling women with cardiovascular disease and prediction of perceived physical activity limitations
Barber, L. A. M., Kimble, L. P., Sudia, T., & Taylor, L. F. (2017) · Applied Nursing Research · doi:10.1016/j.apnr.2017.01.004 · Cited by 2
Provision of mental health care within primary care in Peru: A qualitative study exploring the perspectives of psychologists, primary health care providers, and patients
Cavero, V., Diez‐Canseco, F., Toyama, M., Salcedo, G. F., Ipince, A., Araya, R., & Miranda, J. J. (2018) · Wellcome Open Research · doi:10.12688/wellcomeopenres.13746.1 · Cited by 2
Psychiatric Aspects of Cardiothoracic Surgery
Piddoubny, W., & Caro, M. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-99774-2_8 · Cited by 2
Apports de l’évaluation gérontologique pour les patients cardiovasculaires très âgés
Broussier, A., Valembois, L., Lafuente‐Lafuente, C., David, J., & Pariel, S. (2019) · La Presse Médicale · doi:10.1016/j.lpm.2019.02.004 · Cited by 3
Epidemiological evidence linking stress and depression with CVD
Rutledge, T. R., & Gould, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00002-7 · Cited by 2
Should Doctors Know Their Patients’ Attachment Style? A Psychological Perspective and its Impact on Cardiac Surgery Outcomes
Bithas, C., & Harky, A. (2019) · Brazilian Journal of Cardiovascular Surgery · doi:10.21470/1678-9741-2019-0046 · Cited by 2
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. (2015) · Springer eBooks · doi:10.1007/978-3-642-45028-0_88-1 · Cited by 2
EFFECT OF DIALECTICAL BEHAVIORAL THERAPY ON SUICIDAL ATTEMPTS AND NON- SUICIDAL SELF-INJURY AMONG DEPRESSED PATIENTS
Elsayad, S. M., & Alghtani, I. (2022) · Port Said Scientific Journal of Nursing · doi:10.21608/pssjn.2022.102220.1155 · Cited by 2
Prevalence of depression, anxiety, and stress in cardiovascular patients: a case-control studyPreprint
Janjani, P., Motevaseli, S., Ziapour, A., Karami, S., Rouzbahani, M., & Jalili, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-3904719/v1 · Cited by 2
Implications of Sex Differences on Behavioral and Cardiovascular Health
Mosarla, R. C., & Wood, M. J. (2022) · Psychiatric Annals · doi:10.3928/00485713-20211223-01 · Cited by 1
Psychological and Behavioral Contributions to Rehabilitation and Recovery in Heart Disease
Clarke, D. M., Perera, D. N., & Casey, M. F. (2015) · Springer eBooks · doi:10.1007/978-981-4560-53-5_49-1 · Cited by 1
DepressIon AmoNg CardiovaScular Disease Patients in Libya—PrEvalenCe and AssociaTions: INSPECT Study
Omar, A. (2023) · Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology · doi:10.5543/tkda.2023.62296 · Cited by 1
Stress Hormones
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0025 · Cited by 1
Substance Use and Substance Use Disorders
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0010 · Cited by 2
Marital and Family Stability
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0014 · Cited by 4
Social Support
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0015 · Cited by 1
Predicting incident cardio-metabolic disease among persons with and without depressive and anxiety disorders: a machine learning approach
Rydin, A. O., Aalbers, G., van Eeden, W. A., Lamers, F., Milaneschi, Y., & Penninx, B. W. J. H. (2025) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-025-02857-9 · Cited by 1
Risk of acute myocardial infarction and ischemic stroke in young patients with Somatic Symptom Disorder: A nationwide study in Korea
Kim, I. B., Kim, J., Choi, H. S., Lee, J., Choi, J., Kim, E., Kim, H., Kim, H.-J., & Lee, S.-H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120667 · Cited by 1
Cardiac Rehabilitation and Mental Health
Albuquerque, R. P., Dores, H., & Gonçalves‐Pereira, M. (2026) · Cardiology Clinics · doi:10.1016/j.ccl.2025.11.001 · Cited by 1

Authors: Huffman, J. C., Celano, C. M., Beach, S. R., Motiwala, S. R., & Januzzi, J. L.
Affiliations: Harvard University (US)
Corresponding author: Huffman, Jeff C.
ORCID: Huffman, Jeff C.
Celano, Christopher M.
Beach, Scott R.
Januzzi, James L.
Venue: Cardiovascular Psychiatry and Neurology
Publisher: Wiley
Published: 2013-04-07
Volume: 2013
Pages: 1-14
ISSN: 2090-0163 (ISSN-L)
2090-0171
DOI: 10.1155/2013/695925
PMC: PMC3638710
OpenAlex: W2160660885
Cited by: 445
References: 176
Citations by year: 2026: 19 · 2025: 26 · 2024: 26 · 2023: 71 · 2022: 29 · 2021: 30 · 2020: 64 · 2019: 37 · 2018: 30 · 2017: 29 · 2016: 32 · 2015: 25 · 2014: 21 · 2013: 6
FWCI: 19.05
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Cardiovascular Psychiatry and Neurology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Heart, Lung, and Blood Institute (R01HL113272)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: depression, cardiovascular disease, comorbidities, depression screening, Patient Health Questionnaire, endothelial dysfunction, platelet abnormalities, inflammation, autonomic dysfunction, health behavior, cardiac outcomes, mortality, quality of life, risk factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Depression and cardiac disease: epidemiology, mechanisms, and diagnosis.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks