Towards polypharmacokinetics: pharmacokinetics of multicomponent drugs and herbal medicines using a metabolomics approach

Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Enterotypes of the human gut microbiome

MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works

The human microbiome project

Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091 · see citing works

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works

Systems biology: a brief overview

Kitano, H. (2002) · Science · doi:10.1126/science.1069492 · Cited by 4,265 · see citing works

A framework for human microbiome research

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11209 · Cited by 2,650 · see citing works

Metabonomics

Nicholson, J. K., & Lindon, J. C. (2008) · Nature · doi:10.1038/4551054a · Cited by 1,889 · see citing works

A N <scp>EW</scp> A <scp>PPROACH TO</scp> D <scp>ECODING</scp> L <scp>IFE</scp> : Systems Biology

Ideker, T., Galitski, T., & Hood, L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.343 · Cited by 1,664 · see citing works

Chemometrics in Metabonomics

Trygg, J., Holmes, E. C., & Lundstedt, T. (2006) · Journal of Proteome Research · doi:10.1021/pr060594q · Cited by 1,276 · see citing works

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

Nicholson, J. K., & Wilson, I. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1157 · Cited by 1,121 · see citing works

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., & Nicholson, J. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904489106 · Cited by 765 · see citing works

Metabolic fate of polyphenols in the human superorganism

van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., A. Kemperman, R., van Velzen, E. J. J., Gross, G., Roger, L. C., Possemiers, S., Smilde, A. K., Doré, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000098107 · Cited by 540 · see citing works

Analytical Strategies in Metabonomics

Lenz, E. M., & Wilson, I. D. (2006) · Journal of Proteome Research · doi:10.1021/pr0605217 · Cited by 530 · see citing works

A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model

Martin, F., Dumas, M., Wang, Y., Legido‐Quigley, C., Yap, I. K. S., Tang, H., Zirah, S., Murphy, G. M., Cloarec, O., Lindon, J. C., et al. (2007) · Molecular Systems Biology · doi:10.1038/msb4100153 · Cited by 471 · see citing works

Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease

Compare, D., Coccoli, P., Rocco, A., Nardone, O. M., Maria, S. D., Cartenı̀, M., & Nardone, G. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.02.007 · Cited by 448 · see citing works

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

Martin, F. J., Wang, Y., Sprenger, N., Yap, I. K. S., Lundstedt, T., Lek, P., Rezzi, S., Ramadan, Z., van Bladeren, P., Fay, L. B., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb4100190 · Cited by 421 · see citing works

Multivariate paired data analysis: multilevel PLSDA versus OPLSDA

Westerhuis, J. A., van Velzen, E. J. J., Hoefsloot, H. C. J., & Smilde, A. K. (2009) · Metabolomics · doi:10.1007/s11306-009-0185-z · Cited by 419 · see citing works

The Footprints of Gut Microbial–Mammalian Co-Metabolism

Zheng, X., Xie, G., Zhao, A., Zhao, L., Yao, C., Chiu, N. H. L., Zhou, Z., Bao, Y., Jia, W., Nicholson, J. K., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr2007945 · Cited by 319 · see citing works

Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

Wang, M., Lamers, R.-J. A. N., Korthout, H. A. A. J., van Nesselrooij, J. H. J., Witkamp, R. F., van der Heijden, R., Voshol, P. J., Havekes, L. M., Verpoorte, R., & van der Greef, J. (2005) · Phytotherapy Research · doi:10.1002/ptr.1624 · Cited by 302 · see citing works

Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine.

Wang, X.-J., Sun, H., Zhang, A., Sun, W.-J., Wang, P., & Wang, Z.-G. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.01.042 · Cited by 282 · see citing works

Xenobiotic Metabolomics: Major Impact on the Metabolome

Johnson, C. H., Patterson, A. D., Idle, J. R., & Gonzalez, F. J. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134748 · Cited by 270 · see citing works

Studying Traditional Chinese Medicine

Xue, T., & Roy, R. (2003) · Science · doi:10.1126/science.300.5620.740 · Cited by 264 · see citing works

LC-MS-Based Metabolomics in Drug Metabolism

Chen, C., Gonzalez, F. J., & Idle, J. R. (2007) · Drug Metabolism Reviews · doi:10.1080/03602530701497804 · Cited by 261 · see citing works

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

Björkholm, B., Bok, C. M., Lundin, A., Rafter, J., Hibberd, M. L., & Pettersson, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006958 · Cited by 249 · see citing works

Metabolomics: Towards Understanding Traditional Chinese Medicine

Zhang, A., Sun, H. J., Wang, Z., Sun, W., Wang, P., & Wang, X. (2010) · Planta Medica · doi:10.1055/s-0030-1250542 · Cited by 243 · see citing works

A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion

Wang, Y., Tang, H., Nicholson, J. K., Hylands, P. J., Sampson, J. N., & Holmes, E. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0403282 · Cited by 237 · see citing works

Progress in traditional Chinese medicine

Chan, K. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89019-7 · Cited by 205 · see citing works

Use of liquid chromatography/time‐of‐flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids

Plumb, R. S., Stumpf, C. L., Granger, J. H., Castro‐Perez, J. M., Haselden, J. N., & Dear, G. J. (2003) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1250 · Cited by 193 · see citing works

Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora

Plumb, G. W., García‐Conesa, M., Kroon, P. A., Rhodes, M. J. C., Ridley, S., & Williamson, G. (1999) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(19990301)79:3 · Cited by 189 · see citing works

Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress

Ni, Y., Su, M., Lin, J., Wang, X., Qiu, Y., Zhao, A., Chen, T., & Jia, W. P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.040 · Cited by 173 · see citing works

A Metabolomic Approach to the Metabolism of the Areca Nut Alkaloids Arecoline and Arecaidine in the Mouse

Giri, S., Idle, J. R., Chen, C., Zabriskie, T. M., Krausz, K. W., & Gonzalez, F. J. (2006) · Chemical Research in Toxicology · doi:10.1021/tx0600402 · Cited by 171 · see citing works

Ultra‐performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research

Xie, G., Plumb, R. S., Su, M., Xu, Z., Zhao, A., Qiu, M., Long, X., Liu, Z., & Jia, W. P. (2008) · Journal of Separation Science · doi:10.1002/jssc.200700650 · Cited by 169 · see citing works

Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models

Li, P., Qi, L., Liu, E., Zhou, J., & Wen, X. (2007) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2007.11.005 · Cited by 167 · see citing works

Panorganismal Gut Microbiome−Host Metabolic Crosstalk

Martin, F., Sprenger, N., Yap, I. K. S., Wang, Y., Bibiloni, R., Rochat, F., Rezzi, S., Cherbut, C., Kochhar, S., Lindon, J. C., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr801068x · Cited by 161 · see citing works

Multilevel data analysis of a crossover designed human nutritional intervention study

van Velzen, E. J. J., Westerhuis, J. A., van Duynhoven, J. P. M., van Dorsten, F. A., Hoefsloot, H. C. J., Jacobs, D. M., Smit, S., Draijer, R., Kroner, C. I., & Smilde, A. K. (2008) · Journal of Proteome Research · doi:10.1021/pr800145j · Cited by 161 · see citing works

Identification of Novel Toxicity-associated Metabolites by Metabolomics and Mass Isotopomer Analysis of Acetaminophen Metabolism in Wild-type and Cyp2e1-null Mice

Chen, C., Krausz, K. W., Idle, J. R., & Gonzalez, F. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706299200 · Cited by 143 · see citing works

Metabolic Effects of Dark Chocolate Consumption on Energy, Gut Microbiota, and Stress-Related Metabolism in Free-Living Subjects

Martin, F., Rezzi, S., Peré‐Trepat, E., Kamlage, B., Collino, S., Leibold, E., Kastler, J., Rein, D., Fay, L. B., & Kochhar, S. (2009) · Journal of Proteome Research · doi:10.1021/pr900607v · Cited by 142 · see citing works

Antimutagenic and antimicrobial activities of pu-erh tea

Wu, S., Yen, G., Wang, B.-S., Chiu, C.-K., Yen, W., Chang, L., & Duh, P. (2006) · LWT · doi:10.1016/j.lwt.2005.11.008 · Cited by 139 · see citing works

Liquid chromatography–mass spectrometry in in vitro drug metabolite screening

Tolonen, A., Turpeinen, M., & Pelkonen, O. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.11.002 · Cited by 137 · see citing works

Characterization of Pu-erh Tea Using Chemical and Metabolic Profiling Approaches

Xie, G., Ye, M., Wang, Y., Ni, Y., Su, M., Huang, H., Qiu, M., Zhao, A., Zheng, X., Chen, T., et al. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf804000y · Cited by 136 · see citing works

Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

Cheng, J., Ma, X., Krausz, K. W., Idle, J. R., & Gonzalez, F. J. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.027565 · Cited by 134 · see citing works

Dynamic metabolomic data analysis: a tutorial review

Smilde, A. K., Westerhuis, J. A., Hoefsloot, H. C. J., Bijlsma, S., Rubingh, C. M., Vis, D. J., Jellema, R. H., Pijl, H., Roelfsema, F., & van der Greef, J. (2009) · Metabolomics · doi:10.1007/s11306-009-0191-1 · Cited by 123 · see citing works

The Role of Gut Microbiota in Drug Response

Wilson, I. D., & Nicholson, J. K. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168173 · Cited by 115 · see citing works

Xenobiotic Metabolism: A View through the Metabolometer

Patterson, A. D., Gonzalez, F. J., & Idle, J. R. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100020p · Cited by 114 · see citing works

Strategies for dealing with metabolite elucidation in drug discovery and development

Nassar, A.-E. F., & Talaat, R. E. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(03)03018-6 · Cited by 111 · see citing works

Metabolomics Study of Human Urinary Metabolome Modifications After Intake of Almond (Prunus dulcis(Mill.) D.A. Webb) Skin Polyphenols

Llorach, R., Garrido, I., Monagas, M., Urpí-Sardà, M., Tulipani, S., Bartolomé, B., & Andrés‐Lacueva, C. (2010) · Journal of Proteome Research · doi:10.1021/pr100639v · Cited by 104 · see citing works

Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi

Duan, L.-X., Chen, T., Li, M., Chen, M., Zhou, Y.-Q., Cui, G., Zhao, A., Jia, W. P., Huang, L., & Qi, X. (2011) · Molecular Plant · doi:10.1093/mp/ssr093 · Cited by 102 · see citing works

Metabonomics: systems biology in pharmaceutical research and development.

Lindon, J. C., Holmes, E. C., & Nicholson, J. K. (2004) · PubMed · Cited by 100 · see citing works

Analytical strategy to reveal the in vivo process of multi-component herbal medicine: A pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry

Qiao, X., Ye, M., Cheng, X., Wang, Q., Liu, C., Miao, W., & Guo, D. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.08.041 · Cited by 98 · see citing works

Phenotyping Tea Consumers by Nutrikinetic Analysis of Polyphenolic End-Metabolites

van Velzen, E. J. J., Westerhuis, J. A., van Duynhoven, J., van Dorsten, F. A., Grün, C. H., Jacobs, D. M., Duchateau, G. S. M. J. E., Vis, D. J., & Smilde, A. K. (2009) · Journal of Proteome Research · doi:10.1021/pr801071p · Cited by 96 · see citing works

Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat

Meinl, W., Sczesny, S., Brigelius‐Flohé, R., Blaut, M., & Glatt, H. R. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.025916 · Cited by 96 · see citing works

Nutrimetabolomic Strategies To Develop New Biomarkers of Intake and Health Effects

Llorach, R., Garcia‐Aloy, M., Tulipani, S., Vázquez‐Fresno, R., & Andrés‐Lacueva, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301142b · Cited by 89 · see citing works

From Single Compounds to Herbal Extract: A Strategy to Systematically Characterize the Metabolites of Licorice in Rats

Cheng, X., Qiao, X., Wang, Q., Li, R., Miao, W., Guo, D., & Ye, M. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.038695 · Cited by 89 · see citing works

Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes

Tang, L. Y., Ye, L., Lv, C., Zheng, Z., Gong, Y., & Liu, Z. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.01.019 · Cited by 83 · see citing works

Multivariate approaches for efficient detection of potential metabolites from liquid chromatography/mass spectrometry data

Idborg, H., Edlund, P., & Jacobsson, S. P. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1432 · Cited by 83 · see citing works

Data Preprocessing Method for Liquid Chromatography–Mass Spectrometry Based Metabolomics

Wei, X., Shi, X., Kim, S., Li, Z., Patrick, J. S., Binkley, J., McClain, C. J., & Zhang, X. (2012) · Analytical Chemistry · doi:10.1021/ac3016856 · Cited by 81 · see citing works

The metabolomics of (±)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases

Giri, S., Krausz, K. W., Idle, J. R., & Gonzalez, F. J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.10.017 · Cited by 72 · see citing works

ADME Properties of Herbal Medicines in Humans: Evidence, Challenges and Strategies

He, S., Chan, E., & Zhou, S. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795164194 · Cited by 72 · see citing works

Analytical Strategies for Assessment of Human Metabolites in Preclinical Safety Testing

Ma, S., & Chowdhury, S. K. (2011) · Analytical Chemistry · doi:10.1021/ac200349g · Cited by 71 · see citing works

Metabolomics Provide New Insight on the Metabolism of Dietary Phytochemicals in Rats

Fardet, A., Llorach, R., Orsoni, A., Martin, J., Pujos‐Guillot, E., Lapierre, C., & Scalbert, A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1282 · Cited by 70 · see citing works

Profiling the Reactive Metabolites of Xenobiotics Using Metabolomic Technologies

Li, F., Lu, J. L., & Ma, X. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200033v · Cited by 69 · see citing works

An Integrated Metabolomics and Pharmacokinetics Strategy for Multi-Component Drugs Evaluation

Lan, K., & Jia, W. P. (2010) · Current Drug Metabolism · doi:10.2174/138920010791110926 · Cited by 67 · see citing works

Identification of N-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-guided Biochemical Analysis

Shi, X., Yao, D., & Chen, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.312199 · Cited by 66 · see citing works

Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity

Martin, F., Wang, Y., Yap, I. K. S., Sprenger, N., Lindon, J. C., Rezzi, S., Kochhar, S., Holmes, E. C., & Nicholson, J. K. (2009) · Journal of Proteome Research · doi:10.1021/pr900099x · Cited by 66 · see citing works

A Comprehensive Investigation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Metabolism in the Mouse Using a Multivariate Data Analysis Approach

Chen, C., Ma, X., Malfatti, M. A., Krausz, K. W., Kimura, S., Felton, J. S., Idle, J. R., & Gonzalez, F. J. (2007) · Chemical Research in Toxicology · doi:10.1021/tx600320w · Cited by 65 · see citing works

Chemicalome and Metabolome Matching Approach to Elucidating Biological Metabolic Networks of Complex Mixtures

Gong, P., Cui, N., Wu, L. L., Liang, Y., Hao, K., Xu, X., Tang, W., Wang, G., & Hao, H. (2012) · Analytical Chemistry · doi:10.1021/ac3002353 · Cited by 65 · see citing works

Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine

Wang, Y., Wang, S., Liu, Y., Yan, L., Dou, G., & Gao, Y. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.07.059 · Cited by 64 · see citing works

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC–ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J., & Idle, J. R. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.002 · Cited by 64 · see citing works

A Metabolomic Perspective of Melatonin Metabolism in the Mouse

Ma, X., Chen, C., Krausz, K. W., Idle, J. R., & Gonzalez, F. J. (2008) · Endocrinology · doi:10.1210/en.2007-1412 · Cited by 62 · see citing works

Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation

Cho, J., Kang, D. W., Ma, X., Ahn, S., Krausz, K. W., Luecke, H. F., Idle, J. R., & Gonzalez, F. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800647-jlr200 · Cited by 62 · see citing works

Metabolic Fate of Tea Polyphenols in Humans

Xie, G., Zhao, A., Zhao, L., Chen, T., Chen, H., Qi, X., Zheng, X., Ni, Y., Cheng, Y., Lan, K., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr300318m · Cited by 61 · see citing works

Perspective: All systems go

van der Greef, J. (2011) · Nature · doi:10.1038/480s87a · Cited by 61 · see citing works

Traditional Chinese medicine: balancing the gut ecosystem

Li, H., Zhou, M., Zhao, A., & Jia, W. P. (2009) · Phytotherapy Research · doi:10.1002/ptr.2590 · Cited by 59 · see citing works

Urinary Metabolite Profiling Reveals CYP1A2-Mediated Metabolism of NSC686288 (Aminoflavone)

Chen, C., Meng, L., Ma, X., Krausz, K. W., Pommier, Y. G., Idle, J. R., & Gonzalez, F. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105213 · Cited by 58 · see citing works

Characterization of Endogenous Ethanol in the Mammal

McManus, I. R., Contag, A. O., & Olson, R. E. (1960) · Science · doi:10.1126/science.131.3393.102 · Cited by 56 · see citing works

Methodological aspects for metabolome visualization and characterization

Llorach, R., Jáuregui, O., Urpí-Sardà, M., & Andrés‐Lacueva, C. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.06.033 · Cited by 55 · see citing works

Protective effects of pu-erh tea on LDL oxidation and nitric oxide generation in macrophage cells

Wang, B.-S., Yu, H. M., Chang, L., Yen, W., & Duh, P. (2007) · LWT · doi:10.1016/j.lwt.2007.07.002 · Cited by 54 · see citing works

Metabolomics Data Analysis, Visualization, and Integration

Sumner, L. W., Urbańczyk-Wochniak, E., & Broeckling, C. D. (2005) · Humana Press eBooks · doi:10.1007/978-1-59745-535-0_20 · Cited by 54 · see citing works

Integrated Comparison of Drug-Related and Drug-Induced Ultra Performance Liquid Chromatography/Mass Spectrometry Metabonomic Profiles Using Human Hepatocyte Cultures

Croixmarie, V., Umbdenstock, T., Cloarec, O., Moreau, A., Pascussi, J., Boursier-Neyret, C., & Walther, B. (2009) · Analytical Chemistry · doi:10.1021/ac900333e · Cited by 51 · see citing works

Endogenous ethanol production in a patient with chronic intestinal pseudo-obstruction and small intestinal bacterial overgrowth

Spinucci, G., Guidetti, M., Lanzoni, E., & Pironi, L. (2006) · European Journal of Gastroenterology & Hepatology · doi:10.1097/01.meg.0000223906.55245.61 · Cited by 48 · see citing works

Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC–TOF/MS

Li, C., Qi, L., & Li, P. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.12.034 · Cited by 48 · see citing works

Complementary and Alternative Medicine and the Management of the Metabolic Syndrome

Hollander, J. M., & Mechanick, J. I. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.12.007 · Cited by 45 · see citing works

Application of Metabolomics in Traditional Chinese Medicine Differentiation of Deficiency and Excess Syndromes in Patients with Diabetes Mellitus

Wu, T., Yang, M., Wei, H.-F., He, S.-H., Wang, S.-C., & Ji, G. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/968083 · Cited by 44 · see citing works

Studies of Acetaminophen and Metabolites in Urine and Their Correlations with Toxicity Using Metabolomics

Sun, J., Schnackenberg, L. K., & Beger, R. D. (2009) · Drug Metabolism Letters · doi:10.2174/187231209789352139 · Cited by 42 · see citing works

Simple quality assessment approach for herbal extracts using high performance liquid chromatography-UV based metabolomics platform

Lan, K., Zhang, Y., Yang, J., & Xu, L. (2009) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.12.031 · Cited by 41 · see citing works

Metabolomic Screening and Identification of the Bioactivation Pathways of Ritonavir

Li, F., Lu, J. L., & Ma, X. (2011) · Chemical Research in Toxicology · doi:10.1021/tx2004147 · Cited by 40 · see citing works

Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis

Sun, J., Tungeln, L. S. V., Hines, W. M., & Beger, R. D. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.06.033 · Cited by 38 · see citing works

Multicompartmental LC-Q-TOF-Based Metabonomics as an Exploratory Tool to Identify Novel Pathways Affected by Polyphenol-Rich Diets in Mice

Jové, M., Serrano, J. C. E., Ortega-Olivé, N., Ayala, V., Anglès, N., Reguant, J., Morelló, J. R., Romero, M., Motilva, M., Prat, J., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200132s · Cited by 38 · see citing works

Strategies for Integral Metabolism Profile of Multiple Compounds in Herbal Medicines: Pharmacokinetics, Metabolites Characterization and Metabolic Interactions

Xin, G.-Z., Qi, L., Shi, Z., Li, P., Hao, H., Wang, G., & Shang, J. (2011) · Current Drug Metabolism · doi:10.2174/138920011797470164 · Cited by 37 · see citing works

Metabolomics reveals the metabolic map of procainamide in humans and mice

Li, F., Patterson, A. D., Krausz, K. W., Dick, B., Frey, F. J., Gonzalez, F. J., & Idle, J. R. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.013 · Cited by 36 · see citing works

Nutrikinetics: Concept, technologies, applications, perspectives

van Duynhoven, J., van Velzen, E. J. J., Westerhuis, J. A., Foltz, M., Jacobs, D. M., & Smilde, A. K. (2012) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2012.01.004 · Cited by 35 · see citing works

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC–ESI-QTOFMS-based metabolomics

Li, F., Patterson, A. D., Höfer, C. C., Krausz, K. W., Gonzalez, F. J., & Idle, J. R. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.01.024 · Cited by 32 · see citing works

Fenofibrate Metabolism in the Cynomolgus Monkey using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics

Liu, A., Patterson, A. D., Yang, Z., Zhang, X., Liu, W., Qiu, F. G., Sun, H., Krausz, K. W., Idle, J. R., Gonzalez, F. J., et al. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.025817 · Cited by 30 · see citing works

The Applications and Obstacles of Metabonomics in Traditional Chinese Medicine

Liu, P., Liu, S., Tian, D., & Wang, P. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/945824 · Cited by 29 · see citing works

Metabolite profiling in human urine by LC–MS/MS: Method optimization and application for glucuronides from dextromethorphan metabolism

Lutz, U., Bittner, N., Lutz, R. W., & Lutz, W. K. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.04.018 · Cited by 26 · see citing works

Study of Valproic Acid-Induced Endogenous and Exogenous Metabolite Alterations Using LC–MS-Based Metabolomics

Sun, J., Schnackenberg, L. K., Hansen, D. K., & Beger, R. D. (2010) · Bioanalysis · doi:10.4155/bio.09.173 · Cited by 26 · see citing works

From known knowns to known unknowns: predicting in vivo drug metabolites.

Pelkonen, O., Tolonen, A., Korjamo, T., Turpeinen, M., & Raunio, H. (2009) · Bioanalysis · doi:10.4155/bio.09.32 · Cited by 25 · see citing works

Trend analysis of time-series data: A novel method for untargeted metabolite discovery

Peters, S., Janssen, H., & Vivó‐Truyols, G. (2010) · Analytica Chimica Acta · doi:10.1016/j.aca.2010.01.038 · Cited by 22 · see citing works

New metabolites of fenofibrate in Sprague–Dawley rats by UPLC-ESI-QTOF-MS-based metabolomics coupled with LC-MS/MS

Liu, A., Chen, Y., Yang, Z., Feng, Y., Rui, W., Luo, W., Liu, Y., Gonzalez, F. J., & Dai, R. (2009) · Xenobiotica · doi:10.1080/00498250802680827 · Cited by 21 · see citing works

Analysis of N 1 ‐acetyl‐ N 2 ‐formyl‐5‐methoxykynuramine/ N 1 ‐acetyl‐5‐methoxy‐kynuramine formation from melatonin in mice

Niu, S., Li, F., Tan, D., Zhang, L., Idle, J. R., Gonzalez, F. J., & Ma, X. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00771.x · Cited by 19 · see citing works

Metabolism-Mediated Drug Interactions Associated with Ritonavir-Boosted Tipranavir in Mice

Li, F., Wang, L., Guo, G. L., & Ma, X. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.030817 · Cited by 19 · see citing works

Effect of pH on the Metabolism of Aconitine under Rat Intestinal Bacteria and Analysis of Metabolites Using HPLC/MS‐MSn Technique

Wang, X., Pi, Z., Liu, W., Zhao, Y., & Liu, S. (2010) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201190028 · Cited by 16 · see citing works

3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio

Zhen, Y., Slanař, O., Krausz, K. W., Chen, C., Slavík, J., McPhail, K. L., Zabriskie, T. M., Perlík, F., Gonzalez, F. J., & Idle, J. R. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.008920 · Cited by 14 · see citing works

Metabolic Profiling Assisted Quality Assessment ofRhodiola roseaExtracts by High-Performance Liquid Chromatography

Wang, Z., Hu, H., Chen, F., Zou, L., Ming-fu, Y., Wang, A., Foulsham, J., & Lan, K. (2012) · Planta Medica · doi:10.1055/s-0031-1298373 · Cited by 14 · see citing works

Studies on the Biotransformation of Aconitine in Human Intestinal Bacteria Using Soft-ionization Mass Spectrometry

Yu, Z. (2008) · Cited by 14 · see citing works

Urinary Metabolites of Isoliquiritigenin in Wistar Rats using UHPLC–TOF–MS-based Xenometabolomics

Tan, G., Lou, Z., Dong, X., Li, W., Liao, W., Zhu, Z., & Chai, Y. (2011) · Chromatographia · doi:10.1007/s10337-011-2072-9 · Cited by 10 · see citing works

Utility of multivariate analysis in support ofin vitrometabolite identification studies: retrospective analysis using the antidepressant drug nefazodone

Schneider, R. P., Zhang, H., Mu, L., Kalgutkar, A. S. S., & Bonner, R. F. (2010) · Xenobiotica · doi:10.3109/00498251003592691 · Cited by 9 · see citing works

Low optical power characterization of a base current-biased four-terminal dual-emitter heterojunction phototransistor

Chen, W. T., Chen, H.-H., Hsu, M. K., Chiu, S.-Y., Chen, G. H., Chang, Y.-C., & Lour, W. (2006) · Solid-State Electronics · doi:10.1016/j.sse.2006.06.008 · Cited by 6 · see citing works

The food metabolome: a window over dietary exposure

Scalbert, A., Brennan, L., Manach, C., Andres-Lacueva, C., Dragsted, L. O., Draper, J., Rappaport, S. M., van der Hooft, J. J., & Wishart, D. S. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.076133 · Cited by 519 · see citing works

Current trends in drug metabolism and pharmacokinetics

Li, Y., Meng, Q., Yang, M., Liu, D., Hou, X., Tang, L. Y., Wang, X., Lyu, Y., Chen, X., Liu, K., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.001 · Cited by 409 · see citing works

Knowledge Domain and Emerging Trends in Vinegar Research: A Bibliometric Review of the Literature from WoSCC

Zhang, X.-L., Zheng, Y., Xia, M., Wu, Y., Liu, X.-J., Xie, S., Wu, Y., & Wang, M. (2020) · Foods · doi:10.3390/foods9020166 · Cited by 158 · see citing works

Modern methodologies and tools for human hazard assessment of chemicals

Authority, E. F. S. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3638 · Cited by 99 · see citing works

Application of Combination High‐Throughput Phenotypic Screening and Target Identification Methods for the Discovery of Natural Product‐Based Combination Drugs

Isgut, M., Mukkavilli, R., Yang, C., Subrahmanyam, V., Rida, P. C. G., & Aneja, R. (2017) · Medicinal Research Reviews · doi:10.1002/med.21444 · Cited by 67 · see citing works

Pharmacokinetics of Chinese medicines: strategies and perspectives

Yan, R., Yang, Y. X., & Chen, Y. (2018) · Chinese Medicine · doi:10.1186/s13020-018-0183-z · Cited by 57 · see citing works

Recent Highlights of Metabolomics in Chinese Medicine Syndrome Research

Zhang, A., Sun, H. J., Qiu, S., & Wang, X. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/402159 · Cited by 52 · see citing works

Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification

Tarkang, P. A., Appiah‐Opong, R., Ofori, M. F., Ayong, L. S., & Nyarko, A. K. (2016) · Biomarker Research · doi:10.1186/s40364-016-0077-0 · Cited by 39 · see citing works

Poly‐pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers

Xie, G., Wang, S., Zhang, H., Zhao, A., Liu, J., Ma, Y., Lan, K., Ni, Y., Liu, C., Liu, P., et al. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.784 · Cited by 39 · see citing works

Considerations to Be Taken When Carrying Out Medicinal Plant Research—What We Learn from an Insight into the IC50 Values, Bioavailability and Clinical Efficacy of Exemplary Anti-Inflammatory Herbal Components

Tawab, M. A. (2021) · Pharmaceuticals · doi:10.3390/ph14050437 · Cited by 39 · see citing works

Antiadhesive Activity and Metabolomics Analysis of Rat Urine after Cranberry (Vaccinium macrocarpon Aiton) Administration

Peron, G., Pellizzaro, A., Brun, P., Schievano, E., Mammi, S., Sut, S., Castagliuolo, I., & Dall’Acqua, S. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01856 · Cited by 36 · see citing works

Advances in understanding of health‐promoting benefits of medicine and food homology using analysis of gut microbiota and metabolomics

Yang, M., Yan, T., Yu, M., Kang, J., Gao, R., Wang, P., Zhang, Y., Zhang, H., & Shi, L. S. (2020) · Food Frontiers · doi:10.1002/fft2.49 · Cited by 36 · see citing works

Pharmacokinetics and tissue distribution of eighteen major alkaloids of Aconitum carmichaelii in rats by UHPLC-QQQ-MS

Zhang, Y., Zong, X., Wu, J., Liu, Y., Liu, Z., Zhou, H., Liu, L., & Li, N. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113226 · Cited by 35 · see citing works

Unravelling the Anticancer Mechanisms of Traditional Herbal Medicines with Metabolomics

Oyenihi, O. R., Oyenihi, A. B., Erhabor, J. O., Matsabisa, M. G., & Oguntibeju, O. O. (2021) · Molecules · doi:10.3390/molecules26216541 · Cited by 37 · see citing works

Polyphenolic Nutraceuticals to Combat Oxidative Stress Through Microbiota Modulation

Vamanu, E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00492 · Cited by 34 · see citing works

Pharmacological effects of a C-phycocyanin-based multicomponent nutraceutical in an in-vitro canine chondrocyte model of osteoarthritis.

Martinez, S. E., Chen, Y. A., Ho, E. A., Martinez, S. A., & Davies, N. M. (2015) · Europe PMC (PubMed Central) · Cited by 30 · see citing works

Emerging trends and applications of metabolomics in food science and nutrition

Zhang, J., Sun, M., Elmaidomy, A. H., Youssif, K. A., Zaki, A. M., Kamal, H. H., Sayed, A. M., & Abdelmohsen, U. R. (2023) · Food & Function · doi:10.1039/d3fo01770b · Cited by 27 · see citing works

Metabolic Changes of Maternal Uterine Fluid, Uterus, and Plasma during the Peri-implantation Period of Early Pregnancy in Mice

Yang, Y., Wang, L., Chen, C., Qi, H., Baker, P. N., Liu, X., Zhang, H., & Han, T.-L. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00040-5 · Cited by 22 · see citing works

Follow that botanical: Challenges and recommendations for assessing absorption, distribution, metabolism and excretion of botanical dietary supplements

Suramya Waidyanatha, A., Ryan, K., Roe, A. L., Jia, W. P., Paine, M. F., Ferguson, S., Gurley, B. J., Welch, K. D., Chow, M. S. S., DeVito, M. J., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.062 · Cited by 20 · see citing works

The Anti-inflammatory Potential of Selected Plant-derived Compounds in Respiratory Diseases

Wieczfińska, J., Sitarek, P., Kowalczyk, T., Skała, E., & Pawliczak, R. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200406093257 · Cited by 16 · see citing works

Shaofu Zhuyu decoction ameliorates obesity-mediated hepatic steatosis and systemic inflammation by regulating metabolic pathways

Hong, M., Jung, J., Park, H., Lee, S. M., Jeong, N., Kim, S.-H., Lee, K.-W., Lee, J.-A., & Kim, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178514 · Cited by 16 · see citing works

Phenotyping analysis of the Japanese Kampo medicine maoto in healthy human subjects using wide-targeted plasma metabolomics

Kitagawa, H., Ohbuchi, K., Munekage, M., Fujisawa, K., Kawanishi, Y., Namikawa, T., Kushida, H., Matsumoto, T., Shimobori, C., Nishi, A., et al. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.10.026 · Cited by 16 · see citing works

Pharmacometabolomics in drug safety and drug-exposome interactions

Beger, R. D., & Flynn, T. J. (2016) · Metabolomics · doi:10.1007/s11306-016-1061-2 · Cited by 15 · see citing works

polyPK: an R package for pharmacokinetic analysis of multi-component drugs using a metabolomics approach

Li, M., Wang, S., Xie, G., Ma, X., Chen, T., & Jia, W. P. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx834 · Cited by 14 · see citing works

Phytochemistry, Metabolism, and Metabolomics of Ginseng

Chen, X., Lin, Y., Hu, Y., Liu, C., Lan, K., & Jia, W. P. (2015) · Chinese Herbal Medicines · doi:10.1016/s1674-6384(15)60026-0 · Cited by 13 · see citing works

Metabolomic Study on the Preventive Effect ofPatrinia scabiosaefoliaFisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats

Zou, W., Wen, X., Zheng, Y., Xiao, Z., Luo, J., Chen, S., Wang, Y., Cheng, Z., Xiang, D., & Nie, Y. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/170792 · Cited by 12 · see citing works

Pharmacokinetic Analysis of an Oral Multicomponent Joint Dietary Supplement (Phycox®) in Dogs

Martinez, S. E., Lillico, R., Lakowski, T. M., Martinez, S. A., & Davies, N. M. (2017) · Pharmaceutics · doi:10.3390/pharmaceutics9030030 · Cited by 12 · see citing works

Simultaneous Determination of Twenty-Five Compounds in Rat Plasma Using Ultra-High Performance Liquid Chromatography-Polarity Switching Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study

Zhang, N., Li, Y., Sun, J., Li, C., Song, Y., Li, J., Tu, P., & Zhao, Y. (2017) · Molecules · doi:10.3390/molecules22111853 · Cited by 11 · see citing works

Effects of triangle grass decoction on bone metabolism in rats with chronic kidney disease complicated with mineral and bone abnormalities

Liu, L., Wang, L., Li, L., Wang, H., Yuan, L., Kang, L., Jiang, Q., Chen, G., Lv, N., Cui, X., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114126 · Cited by 10 · see citing works

Hydroxylation Metabolisms of Crassicauline A in Rats Under Toxic Dose

Fan, X., Yin, S.-S., Li, X., Yang, K., Xu, L., & Lan, K. (2017) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-017-0408-z · Cited by 10 · see citing works

Toxicokinetics of Herbal Products

Pelkonen, O., & Ahokas, J. T. (2017) · Springer eBooks · doi:10.1007/978-3-319-43806-1_4 · Cited by 7 · see citing works

Pharmacokinetics study of 16 active ingredients from Tabson‐2 decoction in normal and d ‐galactose induced osteoporosis rats by liquid chromatography–tandem mass spectrometry

Li, N., Dong, X. W., Ma, F.-X., Tian, X., Bu, R., Li, C., Gao, P., Lu, Y., Xue, P., Guo, X., et al. (2020) · Journal of Separation Science · doi:10.1002/jssc.202000355 · Cited by 5 · see citing works

Metabolomics Applications in Herbal Medicine

Hanhineva, K., & Pasanen, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-43806-1_8 · Cited by 4 · see citing works

Quantification of 10 bioactive components of Yazhangsan in rat plasma by LC–MS/MS and its application

Zhang, Q., Chen, S., Liu, A., & Wang, Y. (2020) · Biomedical Chromatography · doi:10.1002/bmc.4958 · Cited by 3 · see citing works

Herbal bioactive–based nutraceuticals using a metabolomics approach

Chahardehi, A. M., & Lim, V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824385-5.00004-2 · Cited by 3 · see citing works

Chromatographic separation and estimation of natural antimalarial flavonoids in biological matrices

Chaturvedi, S., Malik, M. Y., Sultana, N. A., Jahan, S., Singh, S. K., Taneja, I., Kanumuri, R. S., Rashid, M., & Wahajuddin, M. (2021) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-021-00050-5 · Cited by 2 · see citing works

Nutraceuticals in Metabolism and Xenobiotics

Banu, H. (2024) · Food bioactive ingredients · doi:10.1007/978-3-031-76481-3_3 · Cited by 2 · see citing works

Traditional Herbal Medicines: Clinical, Pharmaceutical, and Biological Analysis

Chao-dong, J., Zhao, L., Li, Y.-F., & Zhang, M.-J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14026-0 · Cited by 2 · see citing works

Pharmacokinetic Profile of Kaurenoic Acid after Oral Administration of Araliae Continentalis Radix Extract Powder to Humans

Choi, E.-J., Choi, G.-W., Yang, S.-J., Lee, Y., & Cho, H. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040253 · Cited by 2 · see citing works

Therapeutic Potential of Antileukotriene Drug-Camellia sinensis Extract Co-Formulation on Histamine Induced Asthma in Guinea Pigs

Singh, N., Kulkarni, G. T., & Kumar, Y. (2020) · Current Drug Research Reviews · doi:10.2174/2589977512666200812151620 · Cited by 2 · see citing works

Vietnamese Herbal Opioid Addiction Treatment Medication Heantos-4

Turkia, M. (2021) · Journal of Medicinal Herbs and Ethnomedicine · doi:10.2139/ssrn.3790085 · Cited by 2 · see citing works

Significance of Stability and Pharmacokinetic Issues in Traditional Medicine

Bolla, L., Gangireddy, N. R., Bale, D. N. J., & Satheeshkumar, N. (2021) · Springer eBooks · doi:10.1007/978-981-15-8127-4_36 · Cited by 1 · see citing works

Pharmacokinetics and Metabolomic Profiling of Metformin and Andrographis paniculata: A Protocol for a Crossover Randomised Controlled Trial

Tee, K. B., Ibrahim, L., Hashim, N. M., Saiman, M. Z., Zakaria, Z. H., & Huri, H. Z. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11143931 · Cited by 1 · see citing works

Spectroscopic Methods for Evaluating Nutraceuticals and Nano-Nutraceutical Formulations

Songca, S. P. (2024) · Springer eBooks · doi:10.1007/978-3-030-69677-1_18-1 · Cited by 1 · see citing works

Toxicology and Risk Assessment of Combined Chemicals and Nonchemical Stressors

Rider, C. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00072-3 · Cited by 1 · see citing works

Toxicokinetics of phytonutrients

Chauhdary, Z., Shah, M. A., & Al‐Ghamdi, M. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824467-8.00014-0

Spectroscopic Methods for Evaluating Nutraceutical and Nanonutraceutical Formulations

Songca, S. P. (2026) · Springer eBooks · doi:10.1007/978-3-031-98791-5_18

Review Article Towards Polypharmacokinetics: Pharmacokinetics of Multicomponent Drugs and Herbal Medicines Using a Metabolomics Approach

Lan, K., Xie, G., & Jia, W. (2016)

An Integrated Metabolomics and Pharmacokinetics Strategy for Multi-Component Drugs Evaluation

Lan, K., & Jia, W. P. (2010) · Current Drug Metabolism · doi:10.2174/138920010791110926 · Cited by 67 · see citing works

polyPK: an R package for pharmacokinetic analysis of multi-component drugs using a metabolomics approach

Li, M., Wang, S., Xie, G., Ma, X., Chen, T., & Jia, W. P. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx834 · Cited by 14 · see citing works

Metabolomics and Phytomedicine

Saroya, A. S. (2017) · CRC Press eBooks · doi:10.1201/9781315367071-10

Poly‐pharmacokinetic Study of a Multicomponent Herbal Medicine in Healthy Chinese Volunteers

Xie, G., Wang, S., Zhang, H., Zhao, A., Liu, J., Ma, Y., Lan, K., Ni, Y., Liu, C., Liu, P., et al. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.784 · Cited by 39 · see citing works