Cited by 540Phytochemicals and Antioxidant ActivitiesGut microbiota and healthNutrition, Genetics, and Disease

Metabolic fate of polyphenols in the human superorganism

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van Duynhoven, John, Vaughan, Elaine E., Jacobs, Doris M., A. Kemperman, Robèr, van Velzen, Ewoud J. J., Gross, Gabriele, Roger, Laure C., Possemiers, Sam +4 more·2011·Proceedings of the National Academy of Sciences

Abstract

Dietary polyphenols are components of many foods such as tea, fruit, and vegetables and are associated with several beneficial health effects although, so far, largely based on epidemiological studies. The intact forms of complex dietary polyphenols have limited bioavailability, with low circulating levels in plasma. A major part of the polyphenols persists in the colon, where the resident microbiota produce metabolites that can undergo further metabolism upon entering systemic circulation. Unraveling the complex metabolic fate of polyphenols in this human superorganism requires joint deployment of in vitro and humanized mouse models and human intervention trials. Within these systems, the variation in diversity and functionality of the colonic microbiota can increasingly be captured by rapidly developing microbiomics and metabolomics technologies. Furthermore, metabolomics is coming to grips with the large biological variation superimposed on relatively subtle effects of dietary interventions. In particular when metabolomics is deployed in conjunction with a longitudinal study design, quantitative nutrikinetic signatures can be obtained. These signatures can be used to define nutritional phenotypes with different kinetic characteristics for the bioconversion capacity for polyphenols. Bottom-up as well as top-down approaches need to be pursued to link gut microbial diversity to functionality in nutritional phenotypes and, ultimately, to bioactivity of polyphenols. This approach will pave the way for personalization of nutrition based on gut microbial functionality of individuals or populations.

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  1. [72]Ben-Amor K, Vaughan EE. In: Gastrointestinal Microbiology. Ouwehand A, Vaughan EE, editors. New York: Taylor & Francis Group; 2006. pp. 1–23. [Google Scholar]

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Authors
van Duynhoven, J., Vaughan, E. E., Jacobs, D. M., A. Kemperman, R., van Velzen, E. J. J., Gross, G., Roger, L. C., Possemiers, S., Smilde, A. K., Doré, J., Westerhuis, J. A., & Van de Wiele, T.
Affiliations
  • Unilever R&D, Olivier van Noortlaan 120, 3133 AT, Vlaardingen, The Netherlands;
  • Unilever Research and Development Vlaardingen (NL)
  • Ghent University (BE)
  • Microbiologie de l’alimentation au service de la santé (FR)
  • Netherlands Metabolomics Centre (NL)
  • Institut National de la Recherche Agronomique, UMR 1319 Micalis, 78350 Jouy-en-Josas, France;
  • Laboratory of Microbial Ecology and Technology, Ghent University, B-9000 Ghent, Belgium; and
Venue
Proceedings of the National Academy of Sciences
Published
2010-06-25
Volume
108
Issue
supplement_1
Pages
4531-4538
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2060580528
Cited by
540
References
114
Citations by year
2026: 21 · 2025: 24 · 2024: 24 · 2023: 23 · 2022: 35 · 2021: 33 · 2020: 52 · 2019: 37 · 2018: 38 · 2017: 33 · 2016: 34 · 2015: 36 · 2014: 50 · 2013: 49 · 2012: 34
FWCI
20.51
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • UvA-DARE (University of Amsterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • Fonds Wetenschappelijk Onderzoek
  • Vlaamse regering
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
dietary polyphenols, polyphenol metabolism, gut microbiota, colonic microbiota, bioavailability, humanized mice, personalized nutrition
MeSH terms
Animals, Bacteria, Biological Availability, Colon, Diet, Flavonoids, Humans, Models, Biological, Phenols, Mice, Metagenome, Metabolomics, Polyphenols

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