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Cited by 340

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

Skin Photoaging and the Role of Antioxidants in Its Prevention

Open access
Pandel, Ruža, Poljšak, Borut, Godic, Aleksandar, Dahmane, Raja·2013·ISRN Dermatology

Abstract

Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesized that dermal collagen breakdown is followed by imperfect repair that yields a deficit in the structural integrity of the skin, formation of a solar scar, and ultimately clinically visible skin atrophy and wrinkles. Many studies confirmed that acute exposure of human skin to UVR leads to oxidation of cellular biomolecules that could be prevented by prior antioxidant treatment and to depletion of endogenous antioxidants. Skin has a network of all major endogenous enzymatic and nonenzymatic protective antioxidants, but their role in protecting cells against oxidative damage generated by UV radiation has not been elucidated. It seems that skin’s antioxidative defence is also influenced by vitamins and nutritive factors and that combination of different antioxidants simultaneously provides synergistic effect.

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Citations

Cites

Show all 105 references

Research works printed but not linked: 28

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  4. 2008, Dermatology Nursing, 20, 177
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  6. 2005, Journal der Deutschen Dermatologischen Gesellschaft, 3, S19
  7. 1997, Biological Chemistry, 378, 1275
  8. 2005, Cutis, 75, 5
  9. 10.1016/1011-1344(94)07051-O · doi:10.1016/1011-1344(94)07051-o
  10. 2002, The Scientist, 16, 34
  11. 2002, Acta Dermatovenerologica Alpina, Pannonica et Adriatica, 11, 71
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  16. 1996, European Journal of Dermatology, 6, 200
  17. 1983, Actualizaciones Ter Dermatologica, 6, 49
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  22. 1997, Biochemistry and Molecular Biology International, 42, 1023
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Metadata

Authors
Pandel, R., Poljšak, B., Godic, A., & Dahmane, R.
Venue
ISRN Dermatology
Publisher
Wiley
Published
2013-09-12
Volume
2013
Pages
1-11
ISSN
  • 2090-4592 (ISSN-L)
  • 2090-4606
OpenAlex
W2124317241
Cited by
340
References
105
FWCI
18.95
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Skin Photoaging and the Role of Antioxidants in Its Prevention. https://app.cochat.ai/papers/10.1155/2013/930164
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Pandel, R., Poljšak, B., Godic, A., & Dahmane, R. (2013). Skin Photoaging and the Role of Antioxidants in Its Prevention. ISRN Dermatology. https://doi.org/10.1155/2013/930164

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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