The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Skin Photoaging and the Role of Antioxidants in Its Prevention
Open accessAbstract
Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesized that dermal collagen breakdown is followed by imperfect repair that yields a deficit in the structural integrity of the skin, formation of a solar scar, and ultimately clinically visible skin atrophy and wrinkles. Many studies confirmed that acute exposure of human skin to UVR leads to oxidation of cellular biomolecules that could be prevented by prior antioxidant treatment and to depletion of endogenous antioxidants. Skin has a network of all major endogenous enzymatic and nonenzymatic protective antioxidants, but their role in protecting cells against oxidative damage generated by UV radiation has not been elucidated. It seems that skin’s antioxidative defence is also influenced by vitamins and nutritive factors and that combination of different antioxidants simultaneously provides synergistic effect.
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Cited by
Oxidative Stress in Aging Human Skin
Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053
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Marine Bioactive Compounds and Their Health Benefits: A Review
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Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
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The Role of Antioxidants in Skin Cancer Prevention and Treatment
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Self-citation
Metadata
- Authors
- Pandel, R., Poljšak, B., Godic, A., & Dahmane, R.
- Venue
- ISRN Dermatology
- Publisher
- Wiley
- Published
- 2013-09-12
- Volume
- 2013
- Pages
- 1-11
- ISSN
- 2090-4592 (ISSN-L)
- 2090-4606
- OpenAlex
- W2124317241
- Cited by
- 340
- References
- 105
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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