Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Abstract
Oxygen in biology is essential for life. It comes at a cost during normal cellular function, where reactive oxygen species (ROS) are generated by oxidative metabolism. Human skin exposed to solar ultra-violet radiation (UVR) dramatically increases ROS production/oxidative stress. It is important to understand the characteristics of human skin and how chronological (intrinsic) aging and photo-aging (extrinsic aging) occur via the impact of ROS production by cascade signaling pathways. The goal is to oppose or neutralize ROS insults to maintain good dermal health. Botanicals, as active ingredients, represent one of the largest categories used in dermatology and cosmeceuticals to combat skin aging. An emerging botanical is equol, a polyphenolic/isoflavonoid molecule found in plants and food products and via gastrointestinal metabolism from precursor compounds. Introductory sections cover oxygen, free radicals (ROS), oxidative stress, antioxidants, human skin aging, cellular/molecular ROS events in skin, steroid enzymes/receptors/hormonal actions and genetic factors in aging skin. The main focus of this review covers the characteristics of equol (phytoestrogenic, antioxidant and enhancement of extracellular matrix properties) to reduce skin aging along with its anti-aging skin influences via reducing oxidative stress cascade events by a variety of biochemical/molecular actions and mechanisms to enhance human dermal health.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Up to 80-90% of skin aging is due to environmental and xenobiotic agents (extrinsic aging).
“However, it has been reported that up to 80–90% of skin aging is due to environmental and xenobiotic agents (extrinsic aging) [26, 28].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [26]
Pollution is associated with generation of ROS, which damage DNA, lipids, proteins, mitochondrial function, and increases inflammation.
“Pollution is associated with the generation of reactive oxygen species (ROS), which damage DNA, lipids, proteins, mitochondrial function, and increases inflammation [2].”
Vitamins A, C, and E from diet can act as antioxidants and are found in high concentrations in the epidermis and dermis.
“Other molecules derived from our diet, such as vitamins A, C, and E, can also act as antioxidants which are found in high concentrations in the epidermis and dermis [2,[15][16][17].”
Oxidative stress is a major source of skin aging.
“Additionally, it is well known that oxidative stress is a major source of skin aging, and the mechanisms by which it occurs have been reviewed [2,13,14].”
Skin aging can be classified by intrinsic (chronological) and extrinsic (photoaging) mechanisms.
“Skin aging can be classified by intrinsic (chronological) and extrinsic (photoaging) mechanisms [1,2].”
Skin has a greater antioxidant defense capacity compared to internal organs due to protective structural and biological functioning of dermal layers.
“Finally, and most importantly, the antioxidant defense capacity of the skin is greater compared to internal organs due to the protective structural and biological functioning of the dermal layers [1,2].”
Equol appears to potentially protect against pollution assaults via a variety of mechanisms to increase antioxidant defense, while also decreasing oxidative stress and inflammation.
“Equol, a novel botanical active ingredient compound appears to potentially protect against pollution assaults via a variety of mechanisms to increase antioxidant defense, while also decreasing oxidative stress and inflammation [2].”
Environmental assaults (including pollutants, wind, cold, UV) are associated with oxidative stress and intracellular generation of ROS, which damage DNA, lipids, proteins, and mitochondrial function.
“All of these environmental assaults are associated with oxidative stress and the intracellular generation of reactive oxygen species (ROS), which damage DNA, lipids, proteins and mitochondrial function.”
UVB penetrates into epidermal cells, can damage DNA and activate a cascade leading to generation of ROS and increased photo-aging.
“UVB (280-320 nm), while representing only 2-5% of the sun's emissions, penetrates into epidermal cells, can damage DNA and activate a cascade of events leading to the generation of ROS and increased photo-aging [2,13,23,24].”
Most UV-induced oxidative stress is generated by UVA, which is more cytotoxic to human skin compared to UVB; UVB are mostly mutagenic; both stimulate generation of ROS.
“Thus, most UV-induced oxidative stress is generated by UVA, which is more cytotoxic to human skin compared to UVB; whereas UVB are mostly mutagenic, both are known to stimulate the generation of ROS, [2,13,14,25]”
Dietary intake of food sources containing antioxidants decreases ROS.
“In this regard, the dietary intake of food sources containing antioxidants are known to decrease ROS [2,7,9,22].”
UVA penetrates deeper into dermis to degrade collagen and elastin fibers via oxidative stress mechanisms that activate MMPs and damage mitochondrial structure/function, leading to extrinsic skin photoaging.
“UVA (320-400 nm) at a higher wavelength range represents 95-98% of the total UV radiation reaching the Earth's surface can damage the epidermis and penetrates deeper into the dermis to degrade collagen and elastin fibers via oxidative stress mechanisms that in turn activate matrix metalloproteinases (MMPs) and damage mitochondrial structure/function that leads to extrinsic skin photoaging [2,13,14”
Extrinsic aging comes from external sources that increase oxidative stress, including sunlight (especially UVR), cold weather, and air/water pollution.
“Extrinsic aging comes from external sources that increase oxidative stress, which include sunlight, especially ultraviolet radiation (UVR), temperature conditions, like cold weather, and air/water pollution.”
Both intrinsic and extrinsic factors contribute to generation of ROS-mediated oxidative stress that can impair and damage skin structure and function.
“Both intrinsic and extrinsic factors contribute to the generation of ROS-mediated oxidative stress that can impair and damage skin structure and function [2,22].”
Up to 80-90% of skin aging is due to deleterious effects of sunlight or photoaging.
“It is thought that up to 80-90% of skin aging is due to the deleterious effects of sunlight or photoaging [2,13].”
Intrinsic aging includes ROS production via normal oxidative metabolism within cells that is inevitable, but contributes modestly to skin aging compared to extrinsic aging.
“For example, in intrinsic aging, there is ROS production via normal oxidative metabolism within cells that is inevitable, but contributes in a modest way to skin aging compared to extrinsic aging [2,18,19].”
Equol is classified as a polyphenolic compound.
“Traditionally, equol is classified as a polyphenolic compound.”
Both equol and resveratrol are strong antioxidants when topically applied.
“Notably, both equol and resveratrol are known to be strong antioxidants when topically applied”
Dietary sources commonly known for antioxidant properties include vitamin A, C, and E along with carotenoids, lipoic acid, and phenolic compounds found in plant products like fruits and vegetables.
“Dietary sources that are commonly known for their antioxidant properties include vitamin A, C, and E along with other antioxidants in carotenoids, lipoic acid, and phenolic compounds found in abundance in many plant products like fruits and vegetables [2,17,66].”
S-equol is classified as a selective estrogen receptor modulator (SERM) with high affinity for ERβ.
“Thus, S-equol is classified as a selective estrogen receptor modulator (SERM) with high affinity for ERβ.”
S-equol binds ERβ approximately 1/5 as well as 17β-estradiol, while having low affinity for ERα.
“Remarkably, S-equol binds ERβ approximately 1/5, as well as 17β-estradiol, while having low affinity for ERα [2,78,80].”
Equol (presumably S-equol) is present naturally in some plants, such as beans, cabbage, and lettuces, having a botanical origin.
“Thus, equol (presumably S-equol) is present naturally in some plants, such as beans, cabbage, and lettuces, having a botanical origin [2,78,79]”
Equol is a very strong antioxidant.
“It also has chemical or biological properties, such as being a very strong antioxidant”
Other plant-derived compounds, such as equol, are known to stimulate Nrf2 and increase endogenous detoxifying enzymes and antioxidant production.
“In addition to dietary intake of vitamins and supplementation of antioxidant ingredients, other plant-derived compounds, such as equol, are known to stimulate Nfr2 and increase endogenous detoxifying enzymes and antioxidant production [2,73].”
S-equol is an intestinal metabolite in animals and humans when precursor compounds like daidzein are consumed, but most humans do not generate S-equol concentrations at high levels.
“S-equol is an intestinal metabolite in animals and humans, when precursor compounds (like daidzein) are consumed but, in general, most humans do not generate S-equol concentrations at high levels [2,78,79].”
Equol may increase Nrf2 levels and/or bind to estrogen-responsive elements (EREs) in the promoter region of the Nrf2 gene and/or increase gene expression of other antioxidant genes.
“Specifically, equol may increase Nrf2 levels and/or bind to the estrogen-responsive elements (EREs) in the promoter region the Nrf2 gene and/or increase gene expression of other antioxidant genes [2,97].”
More than 100,000 women have used topically-applied equol with great success.
“more than 100,000 women have used topically-applied equol with great success [2,78,84,85].”
This sustained release of topically-applied equol acts upon fibroblasts and promotes continued positive effects on skin health and addresses oxidative stress.
“This sustained release of topically-applied equol acts upon fibroblasts and promotes continued positive effects on skin health and addresses the issues of oxidative stress [2,85].”
R-equol has weak affinity for either ER and weak estrogenic properties at best.
“Conversely, R-equol has weak affinity for either ER and, in general, has weak estrogenic properties, at best [2,78].”
S-equol is a metabolite of daidzein and is found in plant products such as beans, cabbage, lettuces, tofu, and other food and animal products like eggs and cow's milk.
“S-equol, which is a metabolite of daidzein (an isoflavone found in plant and food products), has been found in plant products such as beans, cabbage, lettuces, tofu, and other food and animal products, like eggs and cow's milk, as reviewed elsewhere [2,78]”
Topical applications of equol have demonstrated improved human dermal parameters in in vitro, ex vivo, and in vivo studies.
“several reports using topical applications of equol have demonstrated improved human dermal parameters”
Equol significantly increases gene and protein expression of collagen and elastin by approximately 2-fold.
“From gene array and human fibroblast cell culture experiments equol has been shown to significantly increase the gene and protein expression of collagen and elastin by approximately 2-fold”
ROS increases MMP production to break down collagen fibers.
“ROS increases MMP production (to break down collagen fibers)”
Nrf2 activation guards against dermal damage from sunlight (ionizing radiation) and oxidative stress via ROS.
“where Nrf2 activation guards against dermal damage, from sunlight (ionizing radiation) and oxidative stress via ROS [2,69-73,76,99].”
Equol appears to address the need as a new active ingredient in personal care products to protect against pollution assaults by increasing antioxidant defense, while inhibiting oxidative stress and inflammation.
“Moreover, equol appears to address the need as a new active ingredient in personal care products to protect against pollution assaults by increasing antioxidant defense, while inhibiting oxidative stress and inflammation [2,78].”
Photoaging or extrinsic aging due to UV light and environmental pollutants trigger oxidative stress and formation of ROS that damages DNA, mitochondrial function, protein, lipids, and results in declination of antioxidant levels.
“photoaging or extrinsic aging due to exposure to UV light along with assaults from environmental pollutants (such as particles, wind or cold) trigger oxidative stress and the formation of ROS that damages DNA, mitochondrial function, protein, lipids, and results in the declination of antioxidant levels [2,13,14].”
Equol increases tissue inhibitor of matrix metalloproteinase 1 (TIMP1) by 5.4-fold.
“along with increasing tissue inhibitor of matrix metalloproteinase 1 (TIMP 1) by 5.4-fold”
The formation of ROS is a widely accepted pivotal mechanism leading to skin aging.
“The formation of ROS is a widely accepted pivotal mechanism leading to skin aging (see Figure 6) [2,13,14].”
ROS activates AP-1 and suppresses TGF beta to decrease pro-collagen synthesis.
“ROS activates AP-1 and suppresses TGF beta to decrease pro-collagen synthesis”
Equol can increase levels of the master gene Nrf2, which regulates endogenous expression of detoxifying proteins and many other antioxidant enzymes involved in wound repair and protection against skin cancer.
“equol itself is a very strong antioxidant, and, in turn, it can increase the levels of the master gene, Nrf2, which regulates the endogenous expression of detoxifying proteins and many other antioxidant enzymes that are involved in wound repair, protection against skin cancer”
ROS activates NF-KB to stimulate the inflammatory response that feeds back in a positive manner to generate more ROS.
“also activates NF-KB to stimulate the inflammatory response that feeds back in a positive manner to generate more ROS”
Equol appears to be an exceptional choice for potential incorporation into human skin applications, especially for women, due to its multiple positive actions to improve dermal health.
“it appears to be an exceptional choice for potential incorporation into human skin applications, especially for women, due to its multiple positive actions to improve dermal health [2,78,108].”
Major factors of extrinsic skin aging include photoaging and environmental pollutants.
“The major factors of extrinsic skin aging include: photoaging and environmental pollutants that, in turn, increase oxidative stress (ROS).”
AP-1 induces MMPs in human skin.
“Additionally, along with ROS's known direct stimulation of MMPs, AP-1 is also known to induce MMPs in human skin that, in turn, activates collagen degradation [2,103].”
Photoaging and environmental pollutants increase oxidative stress (ROS).
“The major factors of extrinsic skin aging include: photoaging and environmental pollutants that, in turn, increase oxidative stress (ROS).”
The cascade of events associated with ROS production results in activation of the inflammatory response.
“The cascade of events associated with ROS production are shown which results in decreased skin antioxidant levels, the degradation of collage, and the activation of the inflammatory response.”
ROS directly stimulates MMPs.
“Additionally, along with ROS's known direct stimulation of MMPs, AP-1 is also known to induce MMPs in human skin that, in turn, activates collagen degradation [2,103].”
The cascade of events associated with ROS production results in decreased skin antioxidant levels.
“The cascade of events associated with ROS production are shown which results in decreased skin antioxidant levels, the degradation of collage, and the activation of the inflammatory response.”
The cascade of events associated with ROS production results in degradation of collagen.
“The cascade of events associated with ROS production are shown which results in decreased skin antioxidant levels, the degradation of collage, and the activation of the inflammatory response.”
AP-1-induced MMPs activate collagen degradation.
“Additionally, along with ROS's known direct stimulation of MMPs, AP-1 is also known to induce MMPs in human skin that, in turn, activates collagen degradation [2,103].”
Cites
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Free radicals, antioxidants and functional foods: impact on human health
Lobo, V, Patil, A., Phatak, A., & Chandra, N. (2010) · Pharmacognosy Reviews · doi:10.4103/0973-7847.70902 · Cited by 5,435 · see citing works
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816 · see citing works
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,128 · see citing works
Ames, B. N., Cathcart, R., Schwiers, E., & Hochstein, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6858 · Cited by 2,915 · see citing works
Introduction to NF-κB: players, pathways, perspectives
Gilmore, T. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209954 · Cited by 2,227 · see citing works
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178 · see citing works
NF-κB, the first quarter-century: remarkable progress and outstanding questions
Hayden, M. S., & Ghosh, S. (2012) · Genes & Development · doi:10.1101/gad.183434.111 · Cited by 1,693 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
Barrier Function of the Skin: “La Raison d'Être” of the Epidermis
Madison, K. C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12359.x · Cited by 1,192 · see citing works
Fitzpatrick's Dermatology in General Medicine.
Cox, N. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.6032_1.x · Cited by 1,164 · see citing works
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Oxidative Stress in the Pathogenesis of Skin Disease
Bickers, D. R., & Athar, M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700340 · Cited by 1,092 · see citing works
Burton, G. J., & Jauniaux, E. R. M. (2010) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2010.10.016 · Cited by 1,028 · see citing works
UV-light-induced signal cascades and skin aging
Rittié, L. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 987 · see citing works
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980 · see citing works
Intrinsic and extrinsic factors in skin ageing: a review
Farage, M. A., Miller, K. W., Elsner, P., & Maibach, H. I. (2008) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2007.00415.x · Cited by 950 · see citing works
Novel insights of dietary polyphenols and obesity
Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 903 · see citing works
Towards the physiological function of uric acid
Becker, B. F. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90143-i · Cited by 832 · see citing works
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.004 · Cited by 762 · see citing works
Rice-Evans, C. A. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373011 · Cited by 719 · see citing works
Female Fecundity as a Function of Age
Fédération, C., Schwartz, D., & Mayaux, M. J. (1982) · New England Journal of Medicine · doi:10.1056/nejm198202183060706 · Cited by 641 · see citing works
Vitamin D : An overview of vitamin D status and intake in E urope
Spiro, A., & Buttriss, J. L. (2014) · Nutrition Bulletin · doi:10.1111/nbu.12108 · Cited by 638 · see citing works
Photoaging: mechanisms and repair
Rabe, J. H., Mamelak, A. J., McElgunn, P. J. S., Morison, W. L., & Sauder, D. N. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.010 · Cited by 610 · see citing works
Molecular aspects of skin ageing
Naylor, E. C., Watson, R. E. B., & Sherratt, M. J. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.04.011 · Cited by 567 · see citing works
Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin
Shindo, Y., Witt, E., Han, D., Epstein, W., & Packer, L. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371744 · Cited by 546 · see citing works
Equol: History, Chemistry, and Formation
Setchell, K. D. R., & Clerici, C. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.119776 · Cited by 519 · see citing works
Skin aging and photoaging: An overview
Gilchrest, B. A. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70227-9 · Cited by 514 · see citing works
Age-Related Mechanical Properties of Human Skin: An In Vivo Study.
Escoffier, C., de Rigal, J., Rochefort, A., Vasselet, R., Lévêque, J.-L., & Agache, P. G. (1989) · Journal of Investigative Dermatology · doi:10.1016/0022-202x(89)90058-4 · Cited by 492 · see citing works
Fundamentals of Anatomy and Physiology
Martini, F. H. (1995) · Medical Entomology and Zoology · Cited by 477 · see citing works
Free radicals in biology and medicine
Rice-Evans, C. A. (1985) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(85)90074-x · Cited by 472 · see citing works
Setchell, K. D., Clerici, C., Lephart, E. D., Cole, S. J., Heenan, C., Castellani, D., Wolfe, B. E., Nechemias-Zimmer, L., Brown, N. M., Lund, T. D., et al. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1072 · Cited by 471 · see citing works
Self-citationKohl, E. A., Steinbauer, J., Landthaler, M., & Szeimies, R. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03963.x · Cited by 443 · see citing works
Fundamentals of Anatomy and Physiology
Chruścik, A., Kauter, K., Windus, L. C. E., Whiteside, E., & Dooley, L. (2023) · University of Southern Queensland ePrints (University of Southern Queensland) · doi:10.26192/q6v2w · Cited by 417 · see citing works
Antioxidant Activities of Isoflavones and Their Biological Metabolites in a Liposomal System
Arora, A., Nair, M. G., & Strasburg, G. M. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0783 · Cited by 404 · see citing works
Skin Photoaging and the Role of Antioxidants in Its Prevention
Mikuš, R. P., Poljšak, B., Godić, A., & Dahmane, R. G. (2013) · ISRN Dermatology · doi:10.1155/2013/930164 · Cited by 358 · see citing works
New insights into skin structure: scratching the surface
Menon, G. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00121-7 · Cited by 352 · see citing works
Clinical aspects and molecular diagnostics of skin aging
Zouboulis, C. C., & Makrantonaki, E. (2011) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.07.001 · Cited by 341 · see citing works
Rothwell, J. A., Day, A. J., & Morgan, M. R. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0483669 · Cited by 329 · see citing works
Antioxidant Efficacy of Phytoestrogens in Chemical and Biological Model Systems
Mitchell, J. H., Gardner, P. T., McPhail, D. B., Morrice, P. C., Collins, A. R., & Duthie, G. G. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0951 · Cited by 322 · see citing works
Antioxidant Activity of Isoflavones and Their Major Metabolites Using Different in Vitro Assays
Rüfer, C. E., & Kulling, S. E. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf053112o · Cited by 321 · see citing works
Oxygen toxicity: chemistry and biology of reactive oxygen species
Buonocore, G., Perrone, S., & Tataranno, M. L. (2010) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2010.04.003 · Cited by 321 · see citing works
Free Radicals and Extrinsic Skin Aging
Poljšak, B., & Dahmane, R. (2012) · Dermatology Research and Practice · doi:10.1155/2012/135206 · Cited by 316 · see citing works
The pharmacology of resveratrol in animals and humans
Park, E.-J., & Pezzuto, J. M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.014 · Cited by 302 · see citing works
Velarde, M. C., Flynn, J. M., Day, N. U., Melov, S., & Campisi, J. (2012) · Aging · doi:10.18632/aging.100423 · Cited by 299 · see citing works
The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure.
Uitto, J. (2008) · PubMed · Cited by 296 · see citing works
Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling
Ashworth, J. L., Murphy, G., Rock, M. J., Sherratt, M. J., SHAPIRO, S. D., Shuttleworth, C. A., & Kielty, C. M. (1999) · Biochemical Journal · doi:10.1042/bj3400171 · Cited by 291 · see citing works
Rhie, G.-E., Shin, M. H., Seo, J. Y., Choi, W. W., Cho, K. H., Kim, K. H., Park, K. C., Eun, H. C., & Chung, J. H. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01469.x · Cited by 274 · see citing works
Age, sunlight, and facial skin: A histologic and quantitative study
Warren, R., Gartstein, V., Kligman, A. M., Montagna, W., Allendorf, R. A., & Ridder, G. M. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(08)80964-4 · Cited by 271 · see citing works
Borrás, C., Gambini, J., Gómez-Cabrera, M. C., Sastre, J., Pallardó, F., Mann, G., & Viña, J. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00151.x · Cited by 257 · see citing works
Changes Associated with the Aging Face
Friedman, O. (2005) · Facial Plastic Surgery Clinics of North America · doi:10.1016/j.fsc.2005.04.004 · Cited by 257 · see citing works
Multifaceted pathways protect human skin from UV radiation
Natarajan, V. T., Ganju, P., Ramkumar, A., Grover, R., & Gokhale, R. S. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1548 · Cited by 244 · see citing works
Mechanisms and implications of the age-associated decrease in DNA repair capacity
Goukassian, D. A., Gad, F., Yaar, M., Eller, M. S., Nehal, U. S., & Gilchrest, B. A. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1325 · Cited by 218 · see citing works
Estrogen suppresses brain mitochondrial oxidative stress in female and male rats
Razmara, A., DUCKLES, S. P., Krause, D. N., & Procaccio, V. (2007) · Brain Research · doi:10.1016/j.brainres.2007.08.036 · Cited by 214 · see citing works
Evidence for nerve growth factor-mediated paracrine effects in human epidermis.
Yaar, M., Grossman, K., Eller, M. S., & Gilchrest, B. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.3.821 · Cited by 200 · see citing works
Strickland, I., Rhodes, L. E., Flanagan, B., & Friedmann, P. S. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12292156 · Cited by 198 · see citing works
Female Fecundity as a Function of Age
Schwartz, D., & Mayaux, M. J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198208000-00019 · Cited by 194 · see citing works
Brincat, M., Baron, Y. M., & Galea, R. P. (2005) · Climacteric · doi:10.1080/13697130500118100 · Cited by 181 · see citing works
Thiele, J. J., Traber, M. G., & Packer, L. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00169.x · Cited by 180 · see citing works
Effect of soy isoflavone supplementation on markers of oxidative stress in men and women
Djurić, Z., Chen, G., Doerge, D. R., Heilbrun, L. K., & Kucuk, O. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00627-9 · Cited by 160 · see citing works
Mann, G. E., Bonacasa, B., Ishii, T., & Siow, R. C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.012 · Cited by 158 · see citing works
Role of UV Light in Photodamage, Skin Aging, and Skin Cancer: Importance of Photoprotection
Gonzaga, E. R. (2009) · American Journal of Clinical Dermatology · doi:10.2165/0128071-200910001-00004 · Cited by 156 · see citing works
Oxidative stress in severe acute illness
Bar‐Or, D., Bar-Or, R., Rael, L. T., & Brody, E. N. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.006 · Cited by 155 · see citing works
Localization of sex steroid receptors in human skin.
Pelletier, G., & Ren, L. (2004) · PubMed · doi:10.14670/hh-19.629 · Cited by 147 · see citing works
Oestrogen receptor beta is the predominant oestrogen receptor in human scalp skin
Thornton, M. J., Taylor, A. H., Mulligan, K., Al‐Azzawi, F., Lyon, C. C., O'Driscoll, J. B., & Messenger, A. G. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.120209.x · Cited by 145 · see citing works
Sun exposure and vitamin D sufficiency
Gilchrest, B. A. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.570s · Cited by 144 · see citing works
Yoon, G.-A., & Park, S. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.6.618 · Cited by 143 · see citing works
Weber, C., Podda, M., Rallis, M., Thiele, J. J., Traber, M. G., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00346-2 · Cited by 140 · see citing works
Antioxidant Enzymes and Human Health
Krishnamurthy, P. T., & Wadhwani, A. (2012) · InTech eBooks · doi:10.5772/48109 · Cited by 139 · see citing works
Low Affinity GPCRs for Metabolic Intermediates: Challenges for Pharmacologists
Smith, N. J. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00001 · Cited by 138 · see citing works
Mazur, W., & Adlercreutz, H. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00333-6 · Cited by 135 · see citing works
Age-related changes in skin wrinkles assessed by a novel three-dimensional morphometric analysis
Akazaki, S., Nakagawa, H., Kazama, H., Osanai, O., Kawai, M., Takema, Y., & Imokawa, G. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04874.x · Cited by 131 · see citing works
Zhai, S., Yaar, M., Doyle, S. M., & Gilchrest, B. A. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0143 · Cited by 121 · see citing works
Chignalia, A. Z., Schuldt, E. Z., Camargo, L. L., Montezano, A. C. I., Callera, G. E., Laurindo, F. R. M., Lopes, L. R., Avellar, M. C. W., de Carvalho, M. H. C., Fortes, Z. B., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.180620 · Cited by 120 · see citing works
Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging
Wend, K., Wend, P., & Krum, S. A. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00019 · Cited by 118 · see citing works
Hornebeck, W. (2003) · Pathologie Biologie · doi:10.1016/j.patbio.2003.09.003 · Cited by 117 · see citing works
Hamilton-Reeves, J. M., Vazquez, G., Duval, S. J., Phipps, W. R., Kurzer, M. S., & Messina, M. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.04.038 · Cited by 115 · see citing works
Delivery of Resveratrol, a Red Wine Polyphenol, from Solutions and Hydrogels via the Skin
Hung, C., Lin, Y., Huang, Z.-R., & Fang, J. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.955 · Cited by 115 · see citing works
Hellemans, L., Corstjens, H., Neven, A.-M., Declercq, L., & Maes, D. H. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12056.x · Cited by 112 · see citing works
Nrf2 promotes survival following exposure to ionizing radiation
Sekhar, K. R., & Freeman, M. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.035 · Cited by 109 · see citing works
Huang, C., Schmid, P. C., Ma, W.-Y., Schmid, H. O., & Dong, Z. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4187 · Cited by 109 · see citing works
The Role of Phytonutrients in Skin Health
Evans, J. A., & Johnson, E. J. (2010) · Nutrients · doi:10.3390/nu2080903 · Cited by 107 · see citing works
Developmental Status of 1-Year-Old Infants Fed Breast Milk, Cow’s Milk Formula, or Soy Formula
Andres, A., Cleves, M. A., Bellando, J. B., Pivik, R. T., Casey, P. H., & Badger, T. M. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3121 · Cited by 100 · see citing works
Elastic fibres in normal and sun-damaged skin: an immunohistochemical study
Mera, S. L., Lovell, C. R., Jones, R. R., & Davies, J. D. (1987) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1987.tb04086.x · Cited by 99 · see citing works
The health implications of soy infant formula
Badger, T. M., Gilchrist, J. M., Pivik, R. T., Andres, A., Shankar, K., Chen, J., & Ronis, M. J. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.26736u · Cited by 99 · see citing works
FAZIO, M. J., Olsen, D. R., Kuivaniemi, H., Chu, M., Davidson, J. M., Rosenbloom, J., & Uitto, J. (1988) · PubMed · Cited by 99 · see citing works
Factors affecting the antioxidant potential and health benefits of plant foods
Li, H., Tsao, R., & Deng, Z. (2012) · Canadian Journal of Plant Science · doi:10.4141/cjps2011-239 · Cited by 97 · see citing works
Setchell, K. D. R., Zhao, X., Jha, P., Heubi, J. E., & Brown, N. M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27981 · Cited by 95 · see citing works
Elastin changes during chronological and photo‐ageing: the important role of lysozyme
Seité, S., Zucchi, H., Septier, D., Changotade, S., Senni, K., & Godeau, G. (2006) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2006.01706.x · Cited by 93 · see citing works
Assessment of isoflavonoid concentrations in Australian bovine milk samples
King, R. A., MANO, M. M., & Head, R. J. (1998) · Journal of Dairy Research · doi:10.1017/s0022029998002891 · Cited by 93 · see citing works
Changes in antioxidant compounds in white cabbage during winter storage
Hounsome, N., Hounsome, B., Tomos, A. D., & Edwards‐Jones, G. (2009) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2008.11.004 · Cited by 92 · see citing works
Kuwazuru, O., Saothong, J., & Yoshikawa, N. (2008) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2007.06.001 · Cited by 90 · see citing works
Reactive oxygen species: players in the cardiovascular effects of testosterone
Tostes, R. C., Carneiro, F. S., de Carvalho, M. H. C., & Reckelhoff, J. F. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00392.2014 · Cited by 90 · see citing works
Cosmetic Dermatology: Principles and Practice
(2003) · Archives of Facial Plastic Surgery · doi:10.1001/archfaci.5.5.448-b · Cited by 89 · see citing works
Expression and Function of Neurotrophins and Their Receptors in Cultured Human Keratinocytes
Terracina, M., Franchi, J., Bonté, F., Romagnoli, G., Maurelli, R., Failla, C. M., Dumas, M., Marconi, A., Fila, C., & Pincelli, C. (2003) · Journal of Investigative Dermatology · doi:10.1111/j.1523-1747.2003.12624.x · Cited by 88 · see citing works
Modulation of Aromatase by Phytoestrogens
Lephart, E. D. (2015) · Enzyme Research · doi:10.1155/2015/594656 · Cited by 86 · see citing works
Self-citationLundh, T., Pettersson, H., & Martinsson, K. A. (1990) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00097a022 · Cited by 85 · see citing works
Gordon, J. R. S., & Brieva, J. C. (2012) · New England Journal of Medicine · doi:10.1056/nejmicm1104059 · Cited by 83 · see citing works
Quan, C., Cho, M. K., Perry, D., & Quan, T. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0167-6 · Cited by 82 · see citing works
Rowlands, D. J., Chapple, S. J., Siow, R. C. M., & Mann, G. E. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.162198 · Cited by 82 · see citing works
Loss of skin elasticity precedes to rapid increase of wrinkle levels
Fujimura, T., Haketa, K., Hotta, M., & Kitahara, T. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.05.002 · Cited by 81 · see citing works
Zhang, T., Liang, X., Shi, L., Wang, L., Chen, J., Kang, C., Zhu, J., & Mi, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079075 · Cited by 80 · see citing works
DEMOGRAPHICS AND PSYCHOLOGICAL IMPLICATIONS FOR THE AGING POPULATION
Kligman, A. M., & Koblenzer, C. (1997) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70464-2 · Cited by 80 · see citing works
Beyond antioxidant genes in the ancient Nrf2 regulatory network
Lacher, S. E., Lee, J. S., Wang, X., Campbell, M. R., Bell, D. A., & Slattery, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.044 · Cited by 77 · see citing works
Beyer, T. A., auf dem Keller, U., Braun, S., Schäfer, M., & Werner, S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402133 · Cited by 77 · see citing works
Davinelli, S., Sapere, N., Visentin, M., Zella, D., & Scapagnini, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-28 · Cited by 76 · see citing works
High levels of equol in organic skimmed Finnish cow milk
Hoikkala, A., Mustonen, E., Saastamoinen, I., Jokela, T., Taponen, J., Saloniemi, H. S., & Wähälä, K. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600222 · Cited by 75 · see citing works
The effect of nerve growth factor on the early responses during the process of wound healing
Nithya, M., Suguna, L., & Rose, C. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00501-9 · Cited by 75 · see citing works
Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivoevidence
Lund, T. D., Blake, C., Bu, L., Hamaker, A., & Lephart, E. D. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-4 · Cited by 73 · see citing works
Self-citationTulah, A. S., & Birch‐Machin, M. A. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.11.007 · Cited by 72 · see citing works
Postmenopausal skin and estrogen
Archer, D. F. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.705392 · Cited by 72 · see citing works
Gopaul, R., Knaggs, H. E., & Lephart, E. D. (2012) · BioFactors · doi:10.1002/biof.191 · Cited by 72 · see citing works
Self-citationKang, N. J., Lee, K. W., Rogozin, E. A., Cho, Y.-Y., Heo, Y.-S., Bode, A. M., Lee, H. J., & Dong, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701459200 · Cited by 71 · see citing works
Does hormone therapy improve age-related skin changes in postmenopausal women?
Phillips, T. J., Symons, J. P., & Menon, S. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.05.009 · Cited by 71 · see citing works
Ma, Y., Sullivan, J. C., & Schreihofer, D. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00031.2010 · Cited by 70 · see citing works
Gilchrist, J. M., Moore, M. B., Andres, A., Estroff, J. A., & Badger, T. M. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.08.043 · Cited by 67 · see citing works
Qin, Z., Voorhees, J. J., Fisher, G. J., & Quan, T. (2014) · Aging Cell · doi:10.1111/acel.12265 · Cited by 65 · see citing works
A role for human mitochondrial complex II in the production of reactive oxygen species in human skin
Anderson, A., Bowman, A., Boulton, S. J., Manning, P., & Birch-Machin, M. A. (2014) · Redox Biology · doi:10.1016/j.redox.2014.08.005 · Cited by 65 · see citing works
Androgens and ageing of the skin
Makrantonaki, E., & Zouboulis, C. C. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832b71dc · Cited by 62 · see citing works
Magee, P. J., Raschke, M., Steiner, C., Duffin, J. G., Pool-Zobel, B. L., Jokela, T., Wähälä, K., & Rowland, I. R. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5402_10 · Cited by 61 · see citing works
Takahashi, Y., Moriwaki, S., Sugiyama, Y., Endo, Y., Yamazaki, K., Mori, T., Takigawa, M., & Inoue, S. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23591.x · Cited by 61 · see citing works
Gou, Z., Jiang, S., Zheng, C., Tian, Z., & Lin, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430124 · Cited by 59 · see citing works
PREOPERATIVE ASSESSMENT OF THE ELDERLY PATIENT
Duncan, K. O., & Leffell, D. J. (1997) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70468-x · Cited by 59 · see citing works
Estrogen receptor signaling protects against immune suppression by UV radiation exposure
Widyarini, S., Domanski, D., Painter, N., & Reeve, V. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603642103 · Cited by 58 · see citing works
Aging and facial changes--documenting clinical signs, part 1: clinical changes of the aging face.
Nkengne, A., & Bertin, C. (2012) · PubMed · Cited by 57 · see citing works
Phytoestrogens, cancer and coronary heart disease
Adlercreutz, H., Heinonen, S., & Peñalvo, J. L. (2004) · BioFactors · doi:10.1002/biof.5520220146 · Cited by 57 · see citing works
The effects of natural S-equol supplementation on skin aging in postmenopausal women
Oyama, A., Ueno, T., Uchiyama, S., Aihara, T., Miyake, A., Kondo, S., & Matsunaga, K. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318227427b · Cited by 57 · see citing works
A Role for Estrogen Receptor-α and Estrogen Receptor-β in Collagen Biosynthesis in Mouse Skin
Markiewicz, M., Znoyko, S. L., Stawski, L., Ghatnekar, A. V., Gilkeson, G. S., & Trojanowska, M. E. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.264 · Cited by 57 · see citing works
Frankenfeld, C. L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.011825 · Cited by 51 · see citing works
Oxidative and Nitrosative Modifications of Tropoelastin Prevent Elastic Fiber Assembly in Vitro
Akhtar, K., Broekelmann, T. J., Miao, M., Keeley, F. W., STARCHER, B. C., Pierce, R. A., Mecham, R. P., & Adair-Kirk, T. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126789 · Cited by 50 · see citing works
17β‐estradiol protects human skin fibroblasts and keratinocytes against oxidative damage
Bottai, G., Mancina, R., Muratori, M., Gennaro, P. D., & Lotti, T. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2012.04697.x · Cited by 49 · see citing works
Pomari, E., Valle, L. D., Pertile, P., Colombo, L., & Thornton, M. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-251363 · Cited by 46 · see citing works
Kang, J. S., Yoon, Y. D., Han, M. H., Han, S.-B., Lee, K., Park, S.-K., & Kim, H. M. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2006.12.004 · Cited by 45 · see citing works
Gruber, F., Ornelas, C. M., Karner, S., Narzt, M.-S., Nagelreiter, I. M., Gschwandtner, M., Bochkov, V., & Tschachler, E. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.006 · Cited by 44 · see citing works
Kang, J. S., Yoon, Y. D., Han, M. H., Han, S.-B., Lee, K., Kang, M. R., Moon, E.-Y., Jeon, Y. J., Park, S.-K., & Kim, H. M. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.10.009 · Cited by 43 · see citing works
Thermal aging: A new concept of skin aging
Seo, J. Y., & Chung, J. H. (2006) · Journal of Dermatological Science Supplement · doi:10.1016/j.descs.2006.08.002 · Cited by 42 · see citing works
Estrogen Receptor β Is a Novel Therapeutic Target for Photoaging
Chang, K. C. N., Wang, Y., Oh, I. G., Jenkins, S. F., Freedman, L. P., Thompson, C. C., Chung, J. H., & Nagpal, S. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.062877 · Cited by 42 · see citing works
Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome
Jackson, R. L., Greiwe, J. S., & Schwen, R. J. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01362.x · Cited by 41 · see citing works
Acute and chronic effects of ultraviolet radiation on the skin.
Walker, S. L., Hawk, J. L. M., & Young, A. R. (2003) · Research Portal (King's College London) · Cited by 40 · see citing works
Cosmetic dermatology: principles and practice
Glaser, D. A. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/s0190-9622(03)01580-9 · Cited by 39 · see citing works
Resveratrol: influences on gene expression in human skin
Lephart, E. D., Sommerfeldt, J. M., & Andrus, M. B. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.017 · Cited by 39 · see citing works
Self-citationIsoflavonoid photoprotection in mouse and human skin is dependent on metallothionein
Widyarini, S., Allanson, M., Gallagher, N. L., Pedley, J., Boyle, G. M., Parsons, P. G., Whiteman, D. C., Walker, C., & Reeve, V. E. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700013 · Cited by 38 · see citing works
Lephart, E. D. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.793720 · Cited by 37 · see citing works
Self-citationHirvonen, J., Rajalin, A.-M., Wohlfahrt, G., Adlercreutz, H., Wähälä, K., & Aarnisalo, P. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.11.001 · Cited by 35 · see citing works
Stem cells and aberrant signaling of molecular systems in skin aging
Peng, Y., Xuan, M., Leung, V. Y. L., & Cheng, B. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.006 · Cited by 35 · see citing works
The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis
Inoue, T., Miki, Y., Abe, K., Hatori, M., Hosaka, M., Kariya, Y., Kakuo, S., Fujimura, T., Hachiya, A., Aiba, S., et al. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.015 · Cited by 34 · see citing works
Froyen, E. B., & Steinberg, F. M. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.008 · Cited by 34 · see citing works
Aging oxidative stress and dietary antioxidants
Preedy, V. R. (2014) · Cited by 34 · see citing works
Degenerative Changes in Aging Skin
Farage, M. A., Miller, K. W., & Maibach, H. I. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_4-2 · Cited by 32 · see citing works
Antioxidant effects of equol on bovine aortic endothelial cells
Chung, J., Kim, S. Y., Jo, H. H., Hwang, S. J., Chae, B., Kwon, D. J., Lew, Y. O., Lim, Y.-T., Kim, J. H., Kim, E. J., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.027 · Cited by 32 · see citing works
Soybean Supplementation Helps Reverse Age- and Scopolamine-Induced Memory Deficits in Mice
Bansal, N., & Parle, M. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1132 · Cited by 31 · see citing works
LEE, M. J., Cha, H. J., Lim, K. M., Lee, O.-K., Bae, S., Kim, C., Lee, K., Lee, Y. N., Ahn, K. J., & An, S. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3478 · Cited by 31 · see citing works
Cheng, C., Wang, X., Weakley, S. M., Kougias, P., Lin, P. H., Yao, Q. C., & Chen, C. (2009) · Journal of Nutrition · doi:10.3945/jn.109.110981 · Cited by 31 · see citing works
Effects of Equol on Oxidized Low-Density Lipoprotein-Induced Apoptosis in Endothelial Cells
Kamiyama, M., Kishimoto, Y., Tani, M., Utsunomiya, K., & Kondo, K. N. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1057 · Cited by 29 · see citing works
In vitropercutaneous absorption of genistein from topical gels through human skin
Chadha, G., Sathigari, S., Parsons, D. L., & Babu, R. J. (2010) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2010.525238 · Cited by 29 · see citing works
Discovery of anS-equol rich food stinky tofu, a traditional fermented soy product in Taiwan
Abiru, Y., Kumemura, M., Ueno, T., Uchiyama, S., & Masaki, K. (2012) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2012.687369 · Cited by 27 · see citing works
Identification of equol in the urine of the domestic fowl
Common, R. H., & AINSWORTH, L. (1961) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(61)90452-8 · Cited by 26 · see citing works
Jain, T., Klein, N. A., Lee, D. M., Sluss, P. M., & Soules, M. R. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00583-0 · Cited by 25 · see citing works
Stinky tofu as a rich source of bioavailable S-equol in Asian diets
Jou, H., Tsai, P., Tu, J.-H., & Wu, W. H. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.01.006 · Cited by 25 · see citing works
Cho, J., Allanson, M., Domanski, D., Arun, S. J., & Reeve, V. E. (2007) · Photochemical & Photobiological Sciences · doi:10.1039/b709856a · Cited by 24 · see citing works
Factors affecting the antioxidant potential and health benefits of plant foods
Li, H., Tsao, R., & Deng, Z. (2012) · BioOne Complete (BioOne) · doi:10.1139/cjps2011-239 · Cited by 24 · see citing works
Review: Anti-Oxidant and Anti-Aging Properties of Equol in Prostate Health (BPH)
Lephart, E. D. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.41001 · Cited by 22 · see citing works
Self-citationOestrogen receptor-β signalling protects against transplanted skin tumour growth in the mouse
Cho, J.-L., Allanson, M., & Reeve, V. E. (2010) · Photochemical & Photobiological Sciences · doi:10.1039/b9pp00168a · Cited by 22 · see citing works
Degen, G. H., Blaszkewicz, M., Shi, L., Buyken, A. E., & Remer, T. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000325 · Cited by 22 · see citing works
Nitsch, S. (2004) · Archives of Surgery · doi:10.1001/archsurg.139.2.157 · Cited by 19 · see citing works
Robinson, J. K., Amonette, R. A., Wyatt, S. W., Bewerse, B. A., Bergfeld, W. F., & Farris, P. K. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70213-0 · Cited by 19 · see citing works
Nitroxide delivery system for Nrf2 activation and skin protection
Ben Yehuda Greenwald, M., Frušić-Zlotkin, M., Soroka, Y., Sasson, S. B., Bianco-Peled, H., Bitton, R., & Kohen, R. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.05.008 · Cited by 18 · see citing works
Widyarini, S., Domanski, D., Painter, N., & Reeve, V. E. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25022e · Cited by 16 · see citing works
Pusparini, P., Yenny, Y., & Hidayat, A. (2015) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666141202123309 · Cited by 14 · see citing works
Role of Antioxidants in Dermal Aging: An In Vitro Study by q-RT-PCR
Avantaggiato, A., Bertuzzi, G., Vitiello, U., Iannucci, G., Pasin, M., Pascali, M., Cervelli, V., & Carinci, F. (2014) · Aesthetic Plastic Surgery · doi:10.1007/s00266-014-0380-9 · Cited by 13 · see citing works
Expression of estrogen-related receptor gamma (ERRgamma) in human skin.
Bertil, E., Bolzinger, M., Andre, V., Orly, I., Kanitakis, J., Rousselle, P., & Damour, O. (2008) · PubMed · doi:10.1684/ejd.2008.0438 · Cited by 13 · see citing works
Park, G., & Oh, M. S. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.8.215 · Cited by 12 · see citing works
Age-related NADH oxidase (arNOX)-catalyzed oxidative damage to skin proteins
Meadows, C., Morré, D. J., Morré, D. M., Draelos, Z. D., & Kern, D. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1472-8 · Cited by 11 · see citing works
Enantiodiscrimination of equol in β-cyclodextrin: an experimental and computational study
Alvira, E., Mayoral, J. A., & García, J. I. (2007) · Journal of Inclusion Phenomena and Macrocyclic Chemistry · doi:10.1007/s10847-007-9358-4 · Cited by 10 · see citing works
Jia, Q., & Nash, J. F. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_28-2 · Cited by 9 · see citing works
A stochastic model for transepidermal drug delivery
Zhong, W., Xing, M. M. Q., Hui, X., & Maïbach, H. I. (2009) · Skin Research and Technology · doi:10.1111/j.1600-0846.2009.00378.x · Cited by 9 · see citing works
In vitrohuman topical bioactive drug transdermal absorption: estradiol
Xing, M. M. Q., Hui, X., Zhong, W., Pan, N., Yaghmaie, F., & Maïbach, H. I. (2009) · Cutaneous and Ocular Toxicology · doi:10.3109/15569520903097622 · Cited by 9 · see citing works
Facial Wrinkling: The Marquee Clinical Sign of Aging Skin
Hillebrand, G. G. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_86 · Cited by 6 · see citing works
Physiological Variations During Aging
Pierard, G., Piérard-Franchimont, C., Nizet, J.-L., & Delvenne, P. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_6-2 · Cited by 5 · see citing works
Facial Wrinkling: The Marquee Clinical Sign of Aging Skin
Hillebrand, G. G. (2016) · Springer eBooks · doi:10.1007/978-3-642-27814-3_86-2 · Cited by 4 · see citing works
Draelos, Z. D., & Pugliese, P. T. (2011) · Cited by 4 · see citing works
S1689 R-Equol Protects Human Gastric Cells From Oxidative Stress-Induced Cell Death
Asciutti, S., Setchell, K. D. R., Gizzi, S., & Clerici, C. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)61159-6 · Cited by 1 · see citing works
Flagged first, then by citations
3 of the 188 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Biomarkers, oxidative stress and autophagy in skin aging
Gu, Y., Han, J., Jiang, C., & Zhang, Y. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101036 · Cited by 768 · see citing works
Taofiq, O., González-Paramás, A., Barreiro, M., & Ferreira, I. (2017) · Molecules · doi:10.3390/molecules22020281 · Cited by 411 · see citing works
Environmental Stressors on Skin Aging. Mechanistic Insights
Parrado, C., Mercado-Sáenz, S., Pérez-Davó, A., Gilaberte, Y., González, S., & Juarranz, Á. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00759 · Cited by 385 · see citing works
An overview of nanoemulsion: concepts of development and cosmeceutical applications
Marzuki, N. H. C., Wahab, R. A., & Hamid, M. A. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2019.1620124 · Cited by 332 · see citing works
Antioxidants from Plants Protect against Skin Photoaging
Petruk, G., Del Giudice, R., Rigano, M. M., & Monti, D. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1454936 · Cited by 283 · see citing works
Steroidogenesis in Leydig cells: effects of aging and environmental factors
Wang, Y., Chen, F., Ye, L., Zirkin, B. R., & Chen, H. (2017) · Reproduction · doi:10.1530/rep-17-0064 · Cited by 256 · see citing works
Astaxanthin: A super antioxidant from microalgae and its therapeutic potential
Kumar, S., Kumar, R., Diksha, Kumari, A., & Panwar, A. (2021) · Journal of Basic Microbiology · doi:10.1002/jobm.202100391 · Cited by 247 · see citing works
Aging in the dermis: Fibroblast senescence and its significance
Zhang, J., Yu, H., Man, M., & Hu, L. (2023) · Aging Cell · doi:10.1111/acel.14054 · Cited by 249 · see citing works
AMPK: Potential Therapeutic Target for Ischemic Stroke
Jiang, S., Li, T. X., Ji, T., Yi, W., Yang, Z. P., Wang, S., Yang, Y., & Gu, C. (2018) · Theranostics · doi:10.7150/thno.25674 · Cited by 252 · see citing works
Liu, H., Cheng, M.-Y., Xun, M., Zhao, Z.-W., Zhang, Y., Tang, W., Cheng, J. J., Ni, J., & Wang, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043755 · Cited by 232 · see citing works
Park, C.-H., Min, S.-Y., Yu, H.-W., Kim, K., Kim, S. Y., Lee, H., Kim, J., & Park, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134620 · Cited by 191 · see citing works
Marine algae as attractive source to skin care
Berthon, J., Nachat, R., Bey, M., Cadoret, J., Renimel, I., & Filaire, E. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1355550 · Cited by 173 · see citing works
Isolation of Industrial Important Bioactive Compounds from Microalgae
Balasubramaniam, V. R. M. T., Rathi, D.-N. G., Mustar, S., Lee, J. C., & Noh, M. F. M. (2021) · Molecules · doi:10.3390/molecules26040943 · Cited by 159 · see citing works
Kong, Y. R., Jong, Y. X., Balakrishnan, M., Bok, Z. K., Weng, J. K. K., Tay, K. C., Goh, B. H., Ong, Y. S., Chan, K., Lee, L., et al. (2021) · Biology · doi:10.3390/biology10040287 · Cited by 168 · see citing works
García‐Piqueras, J., García‐Mesa, Y., Cárcaba, L., Feito, J., Torres‐Parejo, I., Martín‐Biedma, B., Cobo, J. L., García‐Suárez, O., & Vega, J. A. (2019) · Journal of Anatomy · doi:10.1111/joa.12983 · Cited by 146 · see citing works
Liu, T., Li, N., Yan, Y., Liu, Y., Xiong, K., Liu, Y., Xia, Q., Zhang, H., & Liu, Z. (2019) · Phytotherapy Research · doi:10.1002/ptr.6538 · Cited by 138 · see citing works
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132 · see citing works
Self-citationLephart, E. D., & Naftolin, F. N. (2020) · Dermatology and Therapy · doi:10.1007/s13555-020-00468-7 · Cited by 128 · see citing works
Self-citationRole of Phytochemicals in Skin Photoprotection via Regulation of Nrf2
Chaiprasongsuk, A., & Panich, U. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.823881 · Cited by 128 · see citing works
Coffee Silverskin: A Review on Potential Cosmetic Applications
Bessada, S., C. Alves, R., & P. P. Oliveira, M. (2018) · Cosmetics · doi:10.3390/cosmetics5010005 · Cited by 126 · see citing works
Han, J., Wu, T., Jin, J., Li, Z., Cheng, W., Dai, X., Yang, K., Zhang, H., Zhang, Z., Zhang, H., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01657-6 · Cited by 123 · see citing works
Tanveer, M. A., Rashid, H., & Tasduq, S. A. (2022) · Heliyon · doi:10.1016/j.heliyon.2023.e13580 · Cited by 130 · see citing works
Research Progress on Skin Aging and Active Ingredients
He, X., Wan, F., Su, W., & Xie, W. (2023) · Molecules · doi:10.3390/molecules28145556 · Cited by 126 · see citing works
A review of the role of estrogen in dermal aging and facial attractiveness in women
Lephart, E. D. (2018) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12508 · Cited by 114 · see citing works
Self-citationThe Food-gut Human Axis: The Effects of Diet on Gut Microbiota and Metabolome
Angelis, M. D., Garruti, G., Minervini, F., Bonfrate, L., Portincasa, P., & Gobbetti, M. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170428103848 · Cited by 114 · see citing works
Shift in skin microbiota of Western European women across aging
Jugé, R., Rouaud-Tinguely, P., Breugnot, J., Servaes, K., Grimaldi, C., Roth, M.-P., Coppin, H., & Closs, B. (2018) · Journal of Applied Microbiology · doi:10.1111/jam.13929 · Cited by 112 · see citing works
Milosheska, D., & Roškar, R. (2022) · Advances in Therapy · doi:10.1007/s12325-022-02319-7 · Cited by 112 · see citing works
Current advances of Dendrobium officinale polysaccharides in dermatology: a literature review
Guo, L., Qi, J., Du, D., Yin, L., & Jiang, X. L. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1787470 · Cited by 107 · see citing works
Zhou, S., Cai, H., He, X., Tang, Z., & Lu, S. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215536 · Cited by 101 · see citing works
Polyphenols: A Promising Avenue in Therapeutic Solutions for Wound Care
Guimarães, I., Baptista-Silva, S., Pintado, M., & Oliveira, A. L. (2021) · Applied Sciences · doi:10.3390/app11031230 · Cited by 99 · see citing works
The cosmetic application of cyanobacterial secondary metabolites
Nowruzi, B., Sarvari, G., & Blanco, S. (2020) · Algal Research · doi:10.1016/j.algal.2020.101959 · Cited by 96 · see citing works
Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging
Lee, A.-Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073727 · Cited by 87 · see citing works
The influence of phytoestrogens on different physiological and pathological processes: An overview
Petrine, J. C. P., & Borges, B. D. B. (2020) · Phytotherapy Research · doi:10.1002/ptr.6816 · Cited by 82 · see citing works
Probiotic Bacteria for Healthier Aging: Immunomodulation and Metabolism of Phytoestrogens
Landete, J. M., Gaya, P., Rodríguez, E., Langa, S., Peirotén, Á., Medina, M., & Arqués, J. L. (2017) · BioMed Research International · doi:10.1155/2017/5939818 · Cited by 76 · see citing works
Li, Q., Jiang, L., Feng, J., Wang, X., Wang, X., Xu, X., & Chu, W. (2024) · Environment International · doi:10.1016/j.envint.2024.108638 · Cited by 75 · see citing works
Yao, Y., & Xu, B. (2022) · Polysaccharides · doi:10.3390/polysaccharides3040048 · Cited by 72 · see citing works
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway
Zhang, L., Liu, M., Liu, W., Hu, C., Li, H., Deng, J., Cao, Q., Wang, Y., Hu, W., & Li, Q. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00629-y · Cited by 71 · see citing works
A role for estrogen in skin ageing and dermal biomechanics
Wilkinson, H. N., & Hardman, M. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111513 · Cited by 68 · see citing works
Effects of Natural Polyphenols on Skin and Hair Health: A Review
Sun, M., Deng, Y., Cao, X., Lu, X., Ding, Q., Luo, F., Huang, P., Gao, Y., Liu, M., & Zhao, H. (2022) · Molecules · doi:10.3390/molecules27227832 · Cited by 67 · see citing works
Advances in the Metabolic Mechanism and Functional Characteristics of Equol
Gong, Y., Lv, J., Pang, X., Zhang, S., Zhang, G., Liu, L., Wang, Y., & Li, C. (2023) · Foods · doi:10.3390/foods12122334 · Cited by 68 · see citing works
Gu, C., Li, T. X., Jiang, S., Yang, Z. P., Lv, J., Yi, W., Yang, Y., & Fang, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.08.002 · Cited by 66 · see citing works
Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging
Sundaram, I. K., Sarangi, D. D., Sundararajan, V., George, S., & Mohideen, S. S. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2097-9 · Cited by 61 · see citing works
Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage
Davinelli, S., Bertoglio, J. C., Polimeni, A., & Scapagnini, G. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171109102426 · Cited by 57 · see citing works
Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging
Liu, S., Meng, M., Shen, H., Gao, H., Zhao, Y., Yang, Y., Lin, Z., Yang, L.-R., Zhu, K., Han, R. F., et al. (2021) · Rejuvenation Research · doi:10.1089/rej.2020.2313 · Cited by 57 · see citing works
Lephart, E. D., & Naftolin, F. N. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s333663 · Cited by 57 · see citing works
Self-citationLephart, E. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011218 · Cited by 55 · see citing works
Self-citationYoshikata, R., Myint, K. Z. Y., & Ohta, H. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0050 · Cited by 51 · see citing works
Lephart, E. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061193 · Cited by 50 · see citing works
Self-citationZhu, S., Li, Z., Zhang, F., Liu, F., Ni, P., Chen, C., Jiang, Y., & Lu, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.141053 · Cited by 50 · see citing works
He, J., Dong, Y., Liu, X., Wan, Y., Gu, T., Zhou, X., & Liu, M. (2019) · Antioxidants · doi:10.3390/antiox8090345 · Cited by 49 · see citing works
Investigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations
Boran, R. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.03.058 · Cited by 47 · see citing works
Salem, M. A., Radwan, R. A., Mostafa, E. S., Alseekh, S., Fernie, A. R., & Ezzat, S. M. (2020) · RSC Advances · doi:10.1039/d0ra06047j · Cited by 47 · see citing works
Song, Z., Wu, H., Fang, X., Feng, X., & Zhou, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1336369 · Cited by 45 · see citing works
Lee, P., Kim, J., Kim, E., Lee, S.-H., Choi, K.-Y., Kazlauskas, R. J., & Kim, B. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00624 · Cited by 44 · see citing works
Darawsha, A., Trachtenberg, A., Levy, J., & Sharoni, Y. (2021) · Antioxidants · doi:10.3390/antiox10122023 · Cited by 44 · see citing works
Buranasudja, V., Muangnoi, C., Sanookpan, K., Halim, H., Sritularak, B., & Rojsitthisak, P. (2022) · Nutrients · doi:10.3390/nu14122553 · Cited by 44 · see citing works
Stewart, K., & Lephart, E. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065486 · Cited by 43 · see citing works
Self-citationLephart, E. (2018) · Cosmetics · doi:10.3390/cosmetics5010016 · Cited by 42 · see citing works
Self-citationGuo, K., Liu, R., Jing, R., Wang, L., Li, X., Zhang, K., Fu, M., Ye, J., Hu, Z., Zhao, W., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1036013 · Cited by 41 · see citing works
Espinosa-Olivares, M. A., Delgado‐Buenrostro, N. L., Chirino, Y. I., Trejo‐Márquez, M. A., Pascual-Bustamante, S., & Ganem‐Rondero, A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105533 · Cited by 42 · see citing works
Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
Mo, Q., Fu, H., Zhao, D., Zhang, J., Wang, C., Wang, D., & Li, M. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s337524 · Cited by 41 · see citing works
Maldaner, D. R., Azzolin, V. F., Barbisan, F., Mastella, M. H., Teixeira, C. F., Dihel, A., Duarte, T., Pellenz, N. L. K., Lemos, L. F. C., Negretto, C. M. U., et al. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02728-1 · Cited by 42 · see citing works
Galangin suppresses H2O2‐induced aging in human dermal fibroblasts
Wen, S., Chen, J., Weng, Y., Aneja, R., Chen, C., Huang, C., & Kuo, W. (2017) · Environmental Toxicology · doi:10.1002/tox.22455 · Cited by 41 · see citing works
Filippis, A. D., Perfetto, B., Guerrera, L. P., Oliviero, G., & Baroni, A. (2018) · Lasers in Medical Science · doi:10.1007/s10103-018-2635-1 · Cited by 40 · see citing works
Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes
Park, S. H., Kim, D. S., Kim, S.-G., Lorz, L. R., Choi, E., Lim, H. Y., Hossain, M. A., Jang, S., Choi, Y., Park, K. J., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030651 · Cited by 40 · see citing works
Li, M., Xie, J., Bai, X., & Du, Z. (2020) · Industrial Crops and Products · doi:10.1016/j.indcrop.2020.113059 · Cited by 38 · see citing works
Wu, X., Ma, Y., Li, X., He, N., Zhang, T., Liu, F., Feng, H., & Dong, J. (2023) · Toxicology · doi:10.1016/j.tox.2023.153599 · Cited by 37 · see citing works
Enhancing Skin Anti-Aging through Healthy Lifestyle Factors
Knaggs, H. E., & Lephart, E. D. (2023) · Cosmetics · doi:10.3390/cosmetics10050142 · Cited by 37 · see citing works
Self-citationExogenous Bioactive Peptides Have a Potential Therapeutic Role in Delaying Aging in Rodent Models
Wang, J., Wu, Y., Chen, Z., Chen, Y., Lin, Q., & Liang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031421 · Cited by 38 · see citing works
Marsup, P., Yeerong, K., Neimkhum, W., Sirithunyalug, J., Anuchapreeda, S., To-anun, C., & Chaiyana, W. (2020) · Nanomaterials · doi:10.3390/nano10081565 · Cited by 36 · see citing works
Zhou, X., Du, H.-H., Ni, L., Ran, J., Hu, J. P., Yu, J., & Zhao, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.643089 · Cited by 36 · see citing works
Estrogen Action and Gut Microbiome Metabolism in Dermal Health
Lephart, E. D., & Naftolin, F. N. (2022) · Dermatology and Therapy · doi:10.1007/s13555-022-00759-1 · Cited by 36 · see citing works
Self-citationMitsunari, K., Miyata, Y., Matsuo, T., Mukae, Y., Otsubo, A., Harada, J., Kondo, T., Matsuda, T., Ohba, K., & Sakai, H. (2021) · Molecules · doi:10.3390/molecules26020450 · Cited by 35 · see citing works
Shi, X., Cheng, W., Wang, Q., Zhang, J., Wang, C., Li, M., Zhao, D., Wang, D., & An, Q. (2021) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s334527 · Cited by 35 · see citing works
Resveratrol as a factor preventing skin aging and affecting its regeneration
Leis, K., Pisanko, K., Jundziłł, A., Mazur, E., Męcińska‐Jundziłł, K., & Witmanowski, H. (2022) · Advances in Dermatology and Allergology · doi:10.5114/ada.2022.117547 · Cited by 34 · see citing works
Yoshikata, R., Myint, K. Z. Y., Ohta, H., & Ishigaki, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257332 · Cited by 34 · see citing works
Targeting estrogen signaling and biosynthesis for aged skin repair
Zomer, H. D., & Cooke, P. S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1281071 · Cited by 34 · see citing works
Liu, T., Zhu, S., Yang, Y., Qin, W., Wang, Z., Zhao, Z., Liu, T., Wang, X., Duan, T., Liu, Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116110 · Cited by 33 · see citing works
Sharma, P., Dhiman, T., Negi, R. S., Anshad, O. C., Gupta, K., Bhatti, J. S., & Thareja, S. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.01.035 · Cited by 36 · see citing works
Nirmal, N. P., Demir, D., Ceylan, S., Ahmad, S., Gökşen, G., Koirala, P., & Bono, G. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131119 · Cited by 32 · see citing works
Exosomes derived stem cells as a modern therapeutic approach for skin rejuvenation and hair regrowth
Norouzi, F., Aghajani, S., Vousooghi, N., Sharif, S., Ghahremanzadeh, K., Mokhtari, Z., & Verdi, J. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.10.001 · Cited by 31 · see citing works
Hen collagen hydrolysate alleviates UVA-induced damage in human dermal fibroblasts
Wang, X., Hong, H., & Wu, J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103574 · Cited by 31 · see citing works
Liu, T., Xia, Q., Lv, Y., Wang, Z., Zhu, S., Qin, W., Yang, Y., Liu, T., Wang, X., Zhao, Z., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115935 · Cited by 30 · see citing works
Wang, X., Chen, B., Fang, X., Zhong, Q., Liao, Z., Wang, J., Wu, X., Ma, Y., Li, P., Feng, X., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2154744 · Cited by 31 · see citing works
Chaikhong, K., Chumpolphant, S., Rangsinth, P., Sillapachaiyaporn, C., Chuchawankul, S., Tencomnao, T., & Prasansuklab, A. (2022) · Plants · doi:10.3390/plants12010065 · Cited by 30 · see citing works
de Oliveira, M. M., Daré, R. G., Barizão, É. O., Visentainer, J. V., Romagnolo, M. B., Nakamura, C. V., & Truiti, M. D. C. T. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.03.008 · Cited by 30 · see citing works
Hao, R., Li, M., Li, F., Sun‐Waterhouse, D., & Li, D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156669 · Cited by 29 · see citing works
Guo, L., Yang, Y., Pu, Y., Mao, S., Nie, Y., Liu, Y., & Jiang, X. L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116974 · Cited by 29 · see citing works
Ni, H., Liu, C., Kong, L., Zhai, L., Chen, J., Liu, Q., Chen, Z., Wu, M., Chen, J., Guo, Y., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126718 · Cited by 29 · see citing works
Jaradat, N. A., Zaid, A. N., Hussen, F., Issa, L., Altamimi, M., Fuqaha, B., Nawahda, A., & Assadi, M. (2018) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2018.07.003 · Cited by 29 · see citing works
Effects of Ultraviolet Irradiation on Cellular Senescence in Keratinocytes Versus Fibroblasts
Moon, K., Yang, J., Lee, J. S., Jeong, S.-H., Dhong, E., & Han, S. (2018) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000004904 · Cited by 29 · see citing works
Atractyligenin, a terpenoid isolated from coffee silverskin, inhibits cutaneous photoaging
Xuan, S. H., Lee, N. H., & Park, S. N. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.04.002 · Cited by 28 · see citing works
Brazilian red propolis extract enhances expression of antioxidant enzyme genesin vitroandin vivo
Hotta, S., Uchiyama, S., & Ichihara, K. (2020) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2020.1773756 · Cited by 29 · see citing works
Fang, C., Paul, C. R., Day, C. H., Chang, R., Kuo, C., Ho, T., Hsieh, D. J., Viswanadha, V. P., Kuo, W., & Huang, C. (2020) · Environmental Toxicology · doi:10.1002/tox.23075 · Cited by 29 · see citing works
Kaparekar, P. S., & Anandasadagopan, S. K. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-022-00296-7 · Cited by 28 · see citing works
Li, Q., Bai, D., Qin, L., Shao, M., Zhang, S., Yan, C., Yu, G., & Hao, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110094 · Cited by 28 · see citing works
Cheng, S., Jia, H., Zhang, Y., Zhou, J., Chen, X., Wu, L., & Wang, J. (2022) · Molecules · doi:10.3390/molecules27238568 · Cited by 28 · see citing works
Modulation of the ubiquitin-proteasome system by marine natural products
Vasilopoulou, M. Α., Ioannou, E., Roussis, V., & Chondrogianni, N. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101897 · Cited by 27 · see citing works
Skin Anti-Aging Benefits of a 2% Resveratrol Emulsion
Brinke, A. S. T., Janssens‐Böcker, C., & Kerscher, M. J. (2021) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2021.112015 · Cited by 28 · see citing works
Cosmetic potentials of Prunus domestica L. leaves
Stierlin, É., Azoulay, S., Massi, L., Fernàndez, X., & Michel, T. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8520 · Cited by 27 · see citing works
- Authors
- Lephart, E. D.
- Affiliations
- Brigham Young University (US)
- Corresponding author
- Lephart, Edwin D.
- ORCID
- Lephart, Edwin D.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 31
- Pages
- 36-54
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2502726215
- Cited by
- 325
- References
- 188
- Citations by year
- 2026: 16 · 2025: 36 · 2024: 40 · 2023: 46 · 2022: 52 · 2021: 34 · 2020: 32 · 2019: 27 · 2018: 27 · 2017: 14 · 2016: 1
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- LS/TTO (19-2215)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Keywords
- equol, skin aging, oxidative stress, reactive oxygen species, photoaging, chronological aging, isoflavonoids, phytoestrogens, antioxidants, extracellular matrix, botanicals, cosmeceuticals, steroid hormone receptors, free radicals
- MeSH terms
- Antioxidants, Humans, Oxygen, Skin, Signal Transduction, Skin Aging, Reactive Oxygen Species, Oxidative Stress, Phytoestrogens, Equol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
