Lipid Peroxidation Products in Human Health and Disease 2014
Open accessAbstract
Lipid peroxidation is a complex chain reaction process due to the oxygen-free radicals mediated attack of cell membrane lipids such as polyunsaturated fatty acids (PUFA) resulting in cell damage and dysfunction.The end products of lipid peroxidation yield a variety of highly reactive electrophilic aldehydes, which can act as endogenous danger signals that alter important cell signaling pathways responsible for disease pathogenesis.Recent studies identified potential role of lipid peroxidation products as markers of oxidative stress and biomarkers of human diseases.Indeed, a number of preclinical and clinical studies suggest the involvement of lipid peroxidation products in numerous pathological conditions such as inflammation, atherosclerosis, diabetes, ageing, neurodegenerative diseases, and cancer.The wealth of knowledge we are gathering from the past decade or so will significantly help us to better understand the mechanisms by which lipid peroxidation products trigger pathological aspects and will help to identify novel potential targets for future therapeutic strategies.The 2014 special issue of lipid peroxidation products in human health and disease compiles 16 excellent manuscripts, including clinical studies, research articles and reviews, which provides comprehensive evidence demonstrating the significance of lipid peroxidation products in various pathological conditions.The 3 review articles of this issue discuss how lipid peroxidation products are involved in cell signaling which leads to various pathological conditions.An excellent review article by A. Ayala et al. described in depth how lipid peroxidation-derived aldehydes such as malondialdehyde
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Both peroxyl radicals and alkoxyl radicals are further cyclized and, depending on the type of polyunsaturated fatty acid, degraded into reactive aldehydes such as 4-hydroxynonenal or malondialdehyde.
“Both peroxyl radicals and alkoxyl radicals are further cyclized and dependent on the type of polyunsaturated fatty acid, degraded into reactive aldehydes such as 4-hydroxynonenal (4-HNE) or malondialdehyde (MDA) (Fig. 21) (Ramana et al. 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ramana et al. 2014
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- Authors
- Ramana, K. V., Srivastava, S., & Singhal, S. S.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- University of Louisville (US)
- City Of Hope National Medical Center (US)
- Corresponding author
- Ramana, Kota V.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-3
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4180202
- OpenAlex
- W4213428109
- Cited by
- 64
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- lipid peroxidation, lipid peroxidation products, malondialdehyde, oxidative stress, biomarkers, polyunsaturated fatty acids, oxygen free radicals, signal transduction, inflammation, atherosclerosis, diabetes mellitus, aging, neurodegenerative diseases, cancer
- MeSH terms
- Animals, Disease, Health Status, Humans, Lipid Peroxidation
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