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Cited by 188Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

Mechanisms of T-Cell Immunosuppression by Mesenchymal Stromal Cells: What Do We Know So Far?

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Haddad, Rodrigo, Saldanha-Araujo, Felipe·2014·BioMed Research International
DOI 10.1155/2014/216806PMC PMC4082893
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Abstract

Mesenchymal stromal cells (MSCs) are multipotent cells, which can give rise to several cell types including osteoblasts, adipocytes, and chondroblasts. These cells can be found in a variety of adult and fetal tissues, such as bone marrow, adipose tissue, cord blood, and placenta. In recent years, the biological properties of MSCs have attracted the attention of researchers worldwide due to their potential application for treating a series of clinical situations. Among these properties, special attention should be given to the immunoregulatory potential of those cells. MSCs are able to act on all cells of the immune system, which includes the capacity to inhibit the proliferation and function of T-cells. This feature renders them natural candidates to treat several diseases in which cellular immune response is exacerbated. In this review, we outline the main mechanisms by which MSCs immunosuppress T-cell response, focusing on cell-cell contact, secretion of soluble factors, and regulatory T-cell generation. The influence of surface markers in the immunosuppression process and features of MSCs isolated from different sources are also discussed. Finally, the influences of toll-like receptors and cytokines on the inflammatory microenvironment are highlighted regarding the activation of MSCs to exert their immunoregulatory function.

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  • These immunosuppressive cells suppress the immune system by inhibiting both the trafficking and functionality of T cells through direct and indirect mechanisms.

    “These cells have been found to suppress the immune system by inhibiting both the trafficking and functionality of T cells through direct and indirect mechanisms.256”

    From Drug repurposing for cancer therapy (2024) · cites this paper as [256]

    Section 2 reports that mesenchymal stromal cells suppress T-cell proliferation through cell contact and soluble factors, supporting the claim about T-cell function and direct and indirect mechanisms. Section 2.1 describes attraction of T cells toward these cells, not inhibition of T-cell trafficking; that part of the claim is unsupported. (LLM, conf=0.88)

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    Background

Authors
Haddad, R., & Saldanha-Araujo, F.
Affiliations
  • Universidade de Brasília (BR)
  • Faculty of Health Sciences, University of Brasilia, 70910-900 Brasilia, DF, Brazil
ORCID
Haddad, Rodrigo
Venue
BioMed Research International
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-14
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2014/216806
PMC
PMC4082893
OpenAlex
W2075600844
Cited by
188
References
11
Citations by year
2026: 6 · 2025: 11 · 2024: 14 · 2023: 5 · 2022: 14 · 2021: 29 · 2020: 23 · 2019: 16 · 2018: 22 · 2017: 17 · 2016: 17 · 2015: 14
FWCI
2.40
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
mesenchymal stem cells, T cell suppression, immune regulation, cell-cell contact, soluble factors, regulatory T cells, cell surface markers, Toll-like receptors, cytokines, inflammatory microenvironment, cell-mediated immunity
MeSH terms
Cell Differentiation, Humans, Immunity, Cellular, Immunosuppression Therapy, Osteoblasts, T-Lymphocytes, Adipocytes, Chondrocytes, Mesenchymal Stem Cells

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