Cited by 225Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

CD106 Identifies a Subpopulation of Mesenchymal Stem Cells with Unique Immunomodulatory Properties

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Yang, Zhou Xin, Han, Zhi-Bo, Ji, Yue Ru, Wang, You Wei, Liang, Lu, Chi, Ying, Yang, Shao Guang, Li, Li Na +8 more·2013·PLoS ONE

Abstract

Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant differences among various sources of MSCs and to explore their implications in physiopathology and clinical translation. We compared the phenotype and biological properties among different MSCs isolated from human term placental chorionic villi (CV), umbilical cord (UC), adult bone marrow (BM) and adipose (AD). We found that CD106 (VCAM-1) was expressed highest on the CV-MSCs, moderately on BM-MSCs, lightly on UC-MSCs and absent on AD-MSCs. CV-MSCs also showed unique immune-associated gene expression and immunomodulation. We thus separated CD106(+)cells and CD106(-)cells from CV-MSCs and compared their biological activities. Both two subpopulations were capable of osteogenic and adipogenic differentiation while CD106(+)CV-MSCs were more effective to modulate T helper subsets but possessed decreased colony formation capacity. In addition, CD106(+)CV-MSCs expressed more cytokines than CD106(-)CV-MSCs. These data demonstrate that CD106 identifies a subpopulation of CV-MSCs with unique immunoregulatory activity and reveal a previously unrecognized mechanism underlying immunomodulation of MSCs.

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Authors
Yang, Z. X., Han, Z.-B., Ji, Y. R., Wang, Y. W., Liang, L., Chi, Y., Yang, S. G., Li, L. N., Luo, W. F., Li, J. P., Chen, D. D., Du, W. J., Cao, X. C., Zhuo, G. S., Wang, T., & Han, Z. C.
Affiliations
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
  • Beijing Institute for Stem Cell and Regenerative Medicine (CN)
  • Jinan University (CN)
  • Tianjin Medical University General Hospital (CN)
Venue
PLoS ONE
Published
2013-03-12
Volume
8
Issue
3
Pages
e59354
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2041436853
Cited by
225
References
49
Citations by year
2026: 5 · 2025: 14 · 2024: 18 · 2023: 14 · 2022: 28 · 2021: 22 · 2020: 22 · 2019: 25 · 2018: 20 · 2017: 16 · 2016: 13 · 2015: 10 · 2014: 15 · 2013: 3
FWCI
6.73
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • School of Medicine, Indiana University
  • National Key Research and Development Program of China (2011CB964802, 2011AA020118, 2011CB964800)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
mesenchymal stem cells, VCAM-1, umbilical cord, bone marrow, adipose tissue, immunomodulation, osteogenic differentiation, adipogenesis, cytokine expression, colony formation, cell subpopulations
MeSH terms
Adipose Tissue, Adult, Bone Marrow Cells, Cell Differentiation, Chorion, Female, T-Lymphocytes, Helper-Inducer, Humans, Osteocytes, Pregnancy, Umbilical Cord, Biomarkers, Gene Expression, Cytokines, Adipocytes, Vascular Cell Adhesion Molecule-1, Immunomodulation, Mesenchymal Stem Cells

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