The Effects of Sesquiterpenes-Rich Extract of Alpinia oxyphylla Miq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice
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As a kind of medicine which can also be used as food,Alpinia oxyphylla Miq. has a long clinical history in China. A variety of studies demonstrated the significant neuroprotective activity effects of chloroform (CF) extract from the fruits of Alpinia oxyphylla.In order to further elucidate the possible mechanisms of CF extract which mainly contains sesquiterpenes with neuroprotection on the cognitive ability, mice were injected with A β1−42 and later with CF in this study. The results showed that the long-term treatment of CF enhanced the cognitive performances in behavior tests, increased activities of glutathione peroxidase (GSH-px) and decreased the level of malondialdehyde (MDA), acetylcholinesterase (AChE), and amyloid-β(A β), and reversed the activation of microglia, degeneration of neuronal acidophilia, and nuclear condensation in the cortex and hippocampus. These results demonstrate that CF ameliorates learning and memory deficits by attenuating oxidative stress and regulating the activation of microglia and degeneration of neuronal acidophilia to reinforce cholinergic functions.
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Ethanolic extracts of Alpinia oxyphylla showed 44.49% inhibitory activity against AChE at 0.1 mg/mL.
“In addition, the ethanolic extracts of this plant have shown agood inhibitory activity of 44.49% against AChE at 0.1 mg/mL concentration.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [89]
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Influential
- Authors
- Shi, S.-H., Zhao, X., Liu, B., Li, H., Liu, A.-J., Wu, B., Bi, K.-S., & Jia, Y.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- The Engineering Laboratory of National and Local Union of Quality Control for Traditional Chinese Medicine, School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China
- Corresponding author
- Jia, Ying
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-11
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4142297
- OpenAlex
- W1984781976
- Cited by
- 40
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 1
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Shenyang Scientific Project (F13-287-1-00, F12-153-9-00)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alpinia oxyphylla, sesquiterpenes, chloroform extract, amyloid-beta, amyloid-beta 42, cognitive impairment, neuroprotection, oxidative stress, microglial activation, neurodegeneration, acetylcholinesterase, glutathione peroxidase, malondialdehyde, learning and memory, hippocampus, cortex, cholinergic activity
- MeSH terms
- Acetylcholinesterase, Animals, Behavior, Animal, Cerebral Cortex, Chromatography, High Pressure Liquid, Cognition Disorders, Glutathione Peroxidase, Hippocampus, Male, Malondialdehyde, Mice, Inbred ICR, Peptide Fragments, Plant Extracts, Sesquiterpenes, Amyloid beta-Peptides, Maze Learning, Spectrometry, Mass, Electrospray Ionization, Alpinia, Mice, Amyloid Precursor Protein Secretases
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